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    Porous prosthesis and a method of depositing substances into the pores
    4.
    发明授权
    Porous prosthesis and a method of depositing substances into the pores 有权
    多孔假体和将物质沉积到孔中的方法

    公开(公告)号：US06287628B1

    公开(公告)日：2001-09-11

    申请号：US09390855

    申请日：1999-09-03

    申请人： Syed F. A. Hossainy ,  Li Chen

    发明人： Syed F. A. Hossainy ,  Li Chen

    IPC分类号： A61L2900

    CPC分类号： A61L31/16 ,  A61F2/91 ,  A61L31/146

    摘要： A porous implantable prosthesis is loaded with a substance for subsequent application to biological tissues. A method according to loading the substance to the porous prosthesis is provided. A first fluid in combination with an added substance is applied to the porous prosthesis. During the application, the first fluid containing the substance is capable of penetrating into prosthesis pores. The first fluid is removed and a second fluid is applied to the prosthesis. The second fluid is not capable of significantly penetrating into the pores. Prior to the application of the second fluid, the prosthesis can be immersed in a third fluid and agitated via mechanical perturbation techniques so that any of the substance gathered on the surface of the body, after the application of the first fluid, is removed. The third fluid should not be capable of dissolving the substance.

    摘要翻译： 多孔可植入假体装载有用于随后应用于生物组织的物质。 提供了将物质装载到多孔假体的方法。 将与添加物质组合的第一流体施加到多孔假体。 在施用期间，含有该物质的第一流体能够渗透到假体孔中。 移除第一流体，将第二流体施加到假体。 第二种流体不能显着渗透到孔中。 在施加第二流体之前，可以将假体浸入第三流体中并通过机械扰动技术进行搅拌，使得在施加第一流体之后聚集在身体表面上的任何物质被去除。 第三种液体不能溶解物质。

    Method for etching a micropatterned microdepot prosthesis
    8.
    发明授权
    Method for etching a micropatterned microdepot prosthesis 有权
    蚀刻微图案微型假体的方法

    公开(公告)号：US06558733B1

    公开(公告)日：2003-05-06

    申请号：US09697104

    申请日：2000-10-26

    申请人： Syed F. A. Hossainy ,  Li Chen

    发明人： Syed F. A. Hossainy ,  Li Chen

    IPC分类号： B05D132

    CPC分类号： A61F2/91 ,  A61F2/915 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2250/0068 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/622

    摘要： An implantable prosthesis, for example a stent, is provided having one or more micropatterned microdepots formed in the stent. Depots are formed in the prosthesis via chemical etching and laser fabrication methods, including combinations thereof. They are formed at preselected locations on the body of the prosthesis and have a preselected depth, size, and shape. The depots can have various shapes including a cylindrical, a conical or an inverted-conical shape. Substances such as therapeutic substances, polymeric materials, polymeric materials containing therapeutic substances, radioactive isotopes, and radiopaque materials can be deposited into the depots.

    摘要翻译： 提供了可植入的假体，例如支架，其具有在支架中形成的一个或多个微图案化的微点。 通过化学蚀刻和激光制造方法（包括其组合）在假体中形成库。 它们形成在假体的预选位置，并且具有预选的深度，尺寸和形状。 仓库可以具有各种形状，包括圆柱形，锥形或倒圆锥形。 诸如治疗物质，聚合材料，含有治疗物质的聚合材料，放射性同位素和不透射线材料等物质可以沉积到贮库中。

    Porous prosthesis and a method of depositing substances into the pores
    9.
    发明授权
    Porous prosthesis and a method of depositing substances into the pores 有权
    多孔假体和将物质沉积到孔中的方法

    公开(公告)号：US06379381B1

    公开(公告)日：2002-04-30

    申请号：US09390069

    申请日：1999-09-03

    申请人： Syed F. A. Hossainy ,  Li Chen

    发明人： Syed F. A. Hossainy ,  Li Chen

    IPC分类号： A61F206

    CPC分类号： A61L31/16 ,  A61F2/91 ,  A61L31/146 ,  A61L2300/42

    摘要： An implantable prosthesis, for example a stent, is provided that is capable of being loaded with substances. In one example, the prosthesis is a cylindrical-shaped body having depots or pores formed thereon. The depots can be formed at preselected locations on the body of the prosthesis and can have a preselected depth, size, and shape. The depots can have various shapes including a cylindrical or a conical shape. Substances such as therapeutic substances, polymeric materials, polymeric materials containing therapeutic substances, radioactive isotopes, and radiopaque materials can be deposited into the depots.

    摘要翻译： 提供了可植入假体，例如支架，其能够被装载物质。 在一个示例中，假体是具有形成在其上的储库或孔的圆柱形体。 仓库可以形成在假体的身体上的预选位置，并且可以具有预选的深度，大小和形状。 仓库可以具有各种形状，包括圆柱形或圆锥形。 诸如治疗物质，聚合材料，含有治疗物质的聚合材料，放射性同位素和不透射线材料等物质可以沉积到贮库中。