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公开(公告)号：US20050244363A1
公开(公告)日：2005-11-03
申请号：US10835912
申请日：2004-04-30
申请人： Syed Hossainy , Eugene Michal , Thierry Glauser , Connie Kwok , Stephen Pacetti
发明人： Syed Hossainy , Eugene Michal , Thierry Glauser , Connie Kwok , Stephen Pacetti
IPC分类号： A61K31/727 , A61K31/728 , A61K31/785 , A61L27/00 , A61L31/10 , C08G63/48
CPC分类号： A61L31/10 , A61K31/727 , A61K31/728 , A61K31/785 , A61L31/16 , A61K2300/00 , C08L5/08 , C08L5/10
摘要： Hyaluronic acid (HA) conjugates or crosslinked HAs compositions for coating an implantable device are provided. The implantable device can be used for treating a disorder such as atherosclerosis, thrombosis, restenosis, high cholesterol, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.
摘要翻译： 提供了用于涂覆可植入装置的透明质酸（HA）缀合物或交联的HA组合物。 可植入装置可用于治疗动脉粥样硬化，血栓形成，再狭窄，高胆固醇，出血，血管解剖或穿孔，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等障碍，胆管 梗阻，输尿管阻塞，肿瘤阻塞及其组合。
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2.发明申请Coatings for implantable devices comprising polymers of lactic acid and methods for fabricating the same 审中-公开用于包含乳酸聚合物的可植入装置的涂层及其制造方法公开(公告)号：US20050112170A1
公开(公告)日：2005-05-26
申请号：US10718976
申请日：2003-11-20
申请人： Syed Hossainy , Yiwen Tang , Eugene Michal , Thierry Glauser , Stephen Pacetti , Jessica DesNoyer
发明人： Syed Hossainy , Yiwen Tang , Eugene Michal , Thierry Glauser , Stephen Pacetti , Jessica DesNoyer
IPC分类号： A61F2/00 , A61F2/86 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/14 , A61L31/16 , A61L33/06 , A61M29/02
CPC分类号： A61L31/10 , A61F2/86 , A61F2250/0067 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2300/606 , C08L67/04
摘要： Coatings for an implantable medical device and a method of fabricating thereof are disclosed, the coatings comprising polymers of lactic acid.
摘要翻译： 公开了用于可植入医疗装置的涂层及其制造方法，所述涂层包含乳酸聚合物。
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3.发明申请公开(公告)号：US20050147647A1
公开(公告)日：2005-07-07
申请号：US10746483
申请日：2003-12-24
申请人： Thierry Glauser , Connie Kwok , Charles Claude , Eugene Michal , Yiwen Tang , Irina Astafieva , Stephen Pacetti , John Whatley , Ashok Shah
发明人： Thierry Glauser , Connie Kwok , Charles Claude , Eugene Michal , Yiwen Tang , Irina Astafieva , Stephen Pacetti , John Whatley , Ashok Shah
CPC分类号： A61L31/16 , A61F2250/0067 , A61L31/10 , A61L2300/252 , A61L2300/606 , C08L75/04
摘要： A segmented polyurethane and an amphiphilic random or block copolymer are disclosed. The segmented polyurethane and the amphiphilic random or block copolymer can be used for fabricating a coating for an implantable medical device such as a stent.
摘要翻译： 公开了一种分段聚氨酯和两亲无规或嵌段共聚物。 分段聚氨酯和两亲无规或嵌段共聚物可用于制造可植入医疗装置例如支架的涂层。
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公开(公告)号：US08293890B2
公开(公告)日：2012-10-23
申请号：US10835912
申请日：2004-04-30
申请人： Syed Faiyaz Ahmed Hossainy , Eugene Michal , Thierry Glauser , Connie Kwok , Stephen Dirk Pacetti
发明人： Syed Faiyaz Ahmed Hossainy , Eugene Michal , Thierry Glauser , Connie Kwok , Stephen Dirk Pacetti
CPC分类号： A61L31/10 , A61K31/727 , A61K31/728 , A61K31/785 , A61L31/16 , A61K2300/00 , C08L5/08 , C08L5/10
摘要： Hyaluronic acid (HA) conjugates or crosslinked HAs compositions for coating an implantable device are provided. The implantable device can be used for treating a disorder such as atherosclerosis, thrombosis, restenosis, high cholesterol, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.
摘要翻译： 提供了用于涂覆可植入装置的透明质酸（HA）缀合物或交联的HA组合物。 可植入装置可用于治疗动脉粥样硬化，血栓形成，再狭窄，高胆固醇，出血，血管解剖或穿孔，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等障碍，胆管 梗阻，输尿管阻塞，肿瘤阻塞及其组合。
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公开(公告)号：US20050106203A1
公开(公告)日：2005-05-19
申请号：US10176504
申请日：2002-06-21
申请人： Wouter Roorda , Ni Ding , Stephen Pacetti , Eugene Michal , Ashok Shah , Syed Hossainy
发明人： Wouter Roorda , Ni Ding , Stephen Pacetti , Eugene Michal , Ashok Shah , Syed Hossainy
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/608 , A61L2420/08 , C08L33/10 , C08L33/06
摘要： A coating for a medical device, particularly for a drug eluting stent, is described. The coating can include a polyacrylate, a blend of polyacrylates, or a blend of the polyacrylate with other polymers, for example, poly(ethylene-co-vinyl alcohol).
摘要翻译： 描述了用于医疗装置的涂层，特别是用于药物洗脱支架的涂层。 涂层可以包括聚丙烯酸酯，聚丙烯酸酯的共混物或聚丙烯酸酯与其它聚合物的共混物，例如聚（乙烯 - 共 - 乙烯醇）。
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公开(公告)号：US20060002974A1
公开(公告)日：2006-01-05
申请号：US11212376
申请日：2005-08-26
申请人： Stephen Pacetti , Eugene Michal , Syed Hossainy , Ni Ding , Wouter Roorda
发明人： Stephen Pacetti , Eugene Michal , Syed Hossainy , Ni Ding , Wouter Roorda
IPC分类号： A61K31/737 , A61K31/727 , A61K31/728 , A61F2/00
CPC分类号： A61K31/727 , A61K31/728 , A61K31/737 , A61L31/10 , C08L89/00
摘要： Coatings for medical devices which include polycationic peptides such as L-arginine and methods for fabricating the coatings are disclosed.
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公开(公告)号：US20050266038A1
公开(公告)日：2005-12-01
申请号：US10857141
申请日：2004-05-27
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/42 , C08L1/00 , C08L33/14 , C08L2666/26
摘要： A medical device comprising a coating thereon comprising a biocompatible polymer and heparin is provided herein. Heparin is coupled with the biocompatible polymer via a spacer having a grouping that renders a binding site of the heparin molecule accessible by a binding protein. The medical device can be implanted in a human being for the treatment of a disease such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.
摘要翻译： 本文提供了包括其上的包含生物相容性聚合物和肝素的医疗装置。 肝素通过具有使得肝素分子的结合位点可被结合蛋白使得的分组的间隔物与生物相容性聚合物偶联。 医疗器械可以植入人类用于治疗动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等疾病 ，胆管阻塞，输尿管阻塞，肿瘤阻塞或其组合。
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公开(公告)号：US20060198897A1
公开(公告)日：2006-09-07
申请号：US11213288
申请日：2005-08-26
申请人： Stephen Pacetti , Eugene Michal , Syed Hossainy , Ni Ding , Wouter Roorda
发明人： Stephen Pacetti , Eugene Michal , Syed Hossainy , Ni Ding , Wouter Roorda
CPC分类号： A61K31/727 , A61K31/728 , A61K31/737 , A61L31/10 , C08L89/00
摘要： Coatings for medical devices which include polycationic peptides such as L-arginine and methods for fabricating the coatings are disclosed.
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公开(公告)号：US20060018944A1
公开(公告)日：2006-01-26
申请号：US11213290
申请日：2005-08-26
申请人： Stephen Pacetti , Eugene Michal , Syed Hossainy , Ni Ding , Wouter Roorda
发明人： Stephen Pacetti , Eugene Michal , Syed Hossainy , Ni Ding , Wouter Roorda
IPC分类号： A61K31/727 , A61F13/00
CPC分类号： A61K31/727 , A61K31/728 , A61K31/737 , A61L31/10 , C08L89/00
摘要： Coatings for medical devices which include polycationic peptides such as L-arginine and methods for fabricating the coatings are disclosed.
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公开(公告)号：US09561309B2
公开(公告)日：2017-02-07
申请号：US10857141
申请日：2004-05-27
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/42 , C08L1/00 , C08L33/14 , C08L2666/26
摘要： A medical device comprising a coating thereon comprising a biocompatible polymer and heparin is provided herein. Heparin is coupled with the biocompatible polymer via a spacer having a grouping that renders a binding site of the heparin molecule accessible by a binding protein. The medical device can be implanted in a human being for the treatment of a disease such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.
摘要翻译： 本文提供了包括其上的包含生物相容性聚合物和肝素的医疗装置。 肝素通过具有使得肝素分子的结合位点可被结合蛋白使得的分组的间隔物与生物相容性聚合物偶联。 医疗器械可以植入人类用于治疗动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等疾病 ，胆管阻塞，输尿管阻塞，肿瘤阻塞或其组合。
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