公开(公告)号：US20090061031A1

公开(公告)日：2009-03-05

申请号：US11827135

申请日：2007-07-09

申请人： Sylvia Lee-Huang ,  Paul L. Huang ,  Philip Lin Huang ,  Dawei Zhang ,  John Z.H. Zhang ,  Young Tae Chang ,  Jae Wook Lee ,  Ju Bao ,  Yongtao Sun

发明人： Sylvia Lee-Huang ,  Paul L. Huang ,  Philip Lin Huang ,  Dawei Zhang ,  John Z.H. Zhang ,  Young Tae Chang ,  Jae Wook Lee ,  Ju Bao ,  Yongtao Sun

IPC分类号： A61K36/00 ,  A61K31/351 ,  A61K31/70 ,  A61K38/28 ,  A61K31/4439 ,  A61K31/435 ,  A61K31/366 ,  A61K31/7036 ,  A61P3/00 ,  A61P31/12 ,  A61K31/175 ,  A61K31/445 ,  A61K31/404 ,  A61K31/40 ,  A61K31/427 ,  A61K31/155 ,  A61K31/05

CPC分类号： A61K31/7048 ,  A61K31/05 ,  A61K31/155 ,  A61K31/175 ,  A61K31/351 ,  A61K31/366 ,  A61K31/40 ,  A61K31/404 ,  A61K31/427 ,  A61K31/435 ,  A61K31/4439 ,  A61K31/445 ,  A61K31/70 ,  A61K31/7036 ,  A61K36/00 ,  A61K38/28 ,  A61K45/06

摘要： The present invention relates to methods and pharmaceutical compositions for treating obesity or obesity-related disorders in a subject suffering from or predisposed to developing obesity or an obesity-related disorder, or for inhibiting the infectivity of HIV, by administering oleuropein, an analogue or derivative thereof, or the major metabolites of oleuropein including oleuropein aglycone, hydroxytyrosol, and elenolic acid or their analogues, or derivatives thereof, an iridoid glycoside, or a secoiridoid glycoside or analogues or derivatives thereof, or any combination of the foregoing including olive leave extract. The invention also relates to methods for screening/diagnosing a subject having, or predisposed to having obesity or a related disorder by measuring the expression profiles of an adipogenic gene selected from PPARγ2, LPL and αP2 gene and gene product, or other adipogenic, lipogenic, or lipolytic genes and gene products in an individual. The invention further provides for screening for novel oleuropein analogues.

摘要翻译： 本发明涉及通过给予橄榄苷，类似物或衍生物来治疗患有或倾向于发生肥胖或肥胖相关病症或抑制HIV感染性的受试者中的肥胖或肥胖相关疾病的方法和药物组合物 或橄榄苦蛋白的主要代谢物，包括橄榄苷苷苷元，羟基酪醇和烯诺酸或其类似物或衍生物，环烯醚萜苷，或其类似物或衍生物，或上述物质的任何组合，包括橄榄果提取物。 本发明还涉及通过测量选自PPARgamma2，LPL和αP2基因的脂肪形成基因和基因产物或其它脂肪形成，脂质生成，或其它成分的脂肪形成基因的表达谱来筛选/诊断具有或倾向于具有肥胖症或相关病症的受试者的方法。 或脂肪分解基因和基因产物。 本发明进一步提供了新的橄榄苦苷类似物的筛选。

公开(公告)号：US20110142973A1

公开(公告)日：2011-06-16

申请号：US12932018

申请日：2011-02-16

申请人： Sylvia Lee-Huang ,  Paul L. Huang ,  Philip Lin Huang ,  Dawei Zhang ,  John Z.H. Zhang ,  Young Tae Chang ,  Jae Wook Lee ,  Ju Bao ,  Yongtao Sun

发明人： Sylvia Lee-Huang ,  Paul L. Huang ,  Philip Lin Huang ,  Dawei Zhang ,  John Z.H. Zhang ,  Young Tae Chang ,  Jae Wook Lee ,  Ju Bao ,  Yongtao Sun

IPC分类号： A61K36/63 ,  A61P3/00

CPC分类号： A61K31/7048 ,  A61K31/05 ,  A61K31/155 ,  A61K31/175 ,  A61K31/351 ,  A61K31/366 ,  A61K31/40 ,  A61K31/404 ,  A61K31/427 ,  A61K31/435 ,  A61K31/4439 ,  A61K31/445 ,  A61K31/70 ,  A61K31/7036 ,  A61K36/00 ,  A61K38/28 ,  A61K45/06

摘要： The present invention relates to methods and pharmaceutical compositions for treating obesity or obesity-related disorders in a subject suffering from or predisposed to developing obesity or an obesity-related disorder, or for inhibiting the infectivity of HIV, by administering oleuropein, an analogue or derivative thereof, or the major metabolites of oleuropein including oleuropein aglycone, hydroxytyrosol, and elenolic acid or their analogues, or derivatives thereof, an iridoid glycoside, or a secoiridoid glycoside or analogues or derivatives thereof, or any combination of the foregoing including olive leave extract. The invention also relates to methods for screening/diagnosing a subject having, or predisposed to having obesity or a related disorder by measuring the expression profiles of an adipogenic gene selected from PPARγ2, LPL and αP2 gene and gene product, or other adipogenic, lipogenic, or lipolytic genes and gene products in an individual. The invention further provides for screening for novel oleuropein analogues.

摘要翻译： 本发明涉及通过给予橄榄苷，类似物或衍生物来治疗患有或倾向于发生肥胖或肥胖相关病症或抑制HIV感染性的受试者中的肥胖或肥胖相关疾病的方法和药物组合物 或橄榄苦蛋白的主要代谢物，包括橄榄苷苷苷元，羟基酪醇和烯诺酸或其类似物或衍生物，环烯醚萜苷，或其类似物或衍生物，或上述物质的任何组合，包括橄榄果提取物。 本发明还涉及通过测量选自PPARγ2，LPL和αP2基因的脂肪形成基因和基因产物或其它脂肪生成，脂质生成的脂肪形成基因的表达谱来筛选/诊断具有或倾向于具有肥胖症或相关病症的受试者的方法， 或脂肪分解基因和基因产物。 本发明进一步提供了新的橄榄苦苷类似物的筛选。

公开(公告)号：US08574635B2

公开(公告)日：2013-11-05

申请号：US12932018

申请日：2011-02-16

申请人： Sylvia Lee-Huang ,  Paul L. Huang ,  Philip Lin Huang ,  Dawei Zhang ,  John Z. H. Zhang ,  Young Tae Chang ,  Jae Wook Lee ,  Ju Bao ,  Yongtao Sun

发明人： Sylvia Lee-Huang ,  Paul L. Huang ,  Philip Lin Huang ,  Dawei Zhang ,  John Z. H. Zhang ,  Young Tae Chang ,  Jae Wook Lee ,  Ju Bao ,  Yongtao Sun

IPC分类号： A01N65/00

CPC分类号： A61K31/7048 ,  A61K31/05 ,  A61K31/155 ,  A61K31/175 ,  A61K31/351 ,  A61K31/366 ,  A61K31/40 ,  A61K31/404 ,  A61K31/427 ,  A61K31/435 ,  A61K31/4439 ,  A61K31/445 ,  A61K31/70 ,  A61K31/7036 ,  A61K36/00 ,  A61K38/28 ,  A61K45/06

摘要： The present invention relates to methods and pharmaceutical compositions for treating obesity or obesity-related disorders in a subject suffering from or predisposed to developing obesity or an obesity-related disorder, or for inhibiting the infectivity of HIV, by administering oleuropein, an analogue or derivative thereof, or the major metabolites of oleuropein including oleuropein aglycone, hydroxytyrosol, and elenolic acid or their analogues, or derivatives thereof, an iridoid glycoside, or a secoiridoid glycoside or analogues or derivatives thereof, or any combination of the foregoing including olive leave extract. The invention also relates to methods for screening/diagnosing a subject having, or predisposed to having obesity or a related disorder by measuring the expression profiles of an adipogenic gene selected from PPARγ2, LPL and αP2 gene and gene product, or other adipogenic, lipogenic, or lipolytic genes and gene products in an individual. The invention further provides for screening for novel oleuropein analogues.