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公开(公告)号：US07319099B2
公开(公告)日：2008-01-15
申请号：US10911359
申请日：2004-08-04
申请人： Synese Jolidon , Robert Narquizian , Matthias Heinrich Nettekoven , Roger David Norcross , Emmanuel Pinard , Henri Stadler
发明人： Synese Jolidon , Robert Narquizian , Matthias Heinrich Nettekoven , Roger David Norcross , Emmanuel Pinard , Henri Stadler
IPC分类号： C07D251/48 , C07D241/20 , C07D239/42 , C07D237/20 , A61K31/496 , A61K31/501 , A61K31/53 , A61K31/495 , C07D295/192
CPC分类号： C07D239/42 , C07D213/85 , C07D241/20 , C07D251/42 , C07D257/04 , C07D263/32 , C07D271/06 , C07D295/192 , C07D309/12
摘要： The invention relates to compounds of formula wherein the substituents are described herein. The compounds may be used in the treatment of illnesses based on the glycine uptake inhibitor, such as psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia, dementia and other diseases in which cognitive processes are impaired, such as attention deficit disorders or Alzheimer's disease.
摘要翻译： 本发明涉及下式的化合物，其中取代基在本文中描述。 该化合物可用于基于甘氨酸摄取抑制剂治疗疾病，例如精神病，疼痛，记忆和学习中的神经变性功能障碍，精神分裂症，痴呆等认知过程受损的其他疾病，如注意力缺陷障碍或阿尔茨海默病 疾病。
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公开(公告)号：US07595314B2
公开(公告)日：2009-09-29
申请号：US12177386
申请日：2008-07-22
申请人： Daniela Alberati-Giani , Synese Jolidon , Robert Narquizian , Matthias Heinrich Nettekoven , Roger David Norcross , Emmanuel Pinard , Henri Stalder
发明人： Daniela Alberati-Giani , Synese Jolidon , Robert Narquizian , Matthias Heinrich Nettekoven , Roger David Norcross , Emmanuel Pinard , Henri Stalder
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/55 , C07D413/12
CPC分类号： C07D295/192 , A61K31/495 , A61K31/496 , C07D207/08 , C07D207/12 , C07D207/20 , C07D211/42 , C07D231/12 , C07D233/54 , C07D237/20 , C07D249/08 , C07D257/04 , C07D307/14 , C07D309/14
摘要： A compound of formula wherein the substituents are as described in the specification for the treatment of psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia, dementia and other diseases in which cognitive processes are impaired, such as attention deficit disorders or Alzheimer's disease.
摘要翻译： 式的化合物，其中取代基如治疗精神病，疼痛，记忆和学习中的神经变性功能障碍，精神分裂症，痴呆和其他认知过程受损的其他疾病（如注意力缺陷障碍或阿尔茨海默氏病）的描述中所述。
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公开(公告)号：US20090192136A1
公开(公告)日：2009-07-30
申请号：US12177386
申请日：2008-07-22
申请人： Daniela Alberati-Giani , Synese Jolidon , Robert Narquizian , Matthias Heinrich Nettekoven , Roger David Norcross , Emmanuel Pinard , Henri Stalder
发明人： Daniela Alberati-Giani , Synese Jolidon , Robert Narquizian , Matthias Heinrich Nettekoven , Roger David Norcross , Emmanuel Pinard , Henri Stalder
IPC分类号： A61K31/496 , C07D413/10 , C07D241/04 , A61K31/55 , A61K31/5377 , A61P25/00 , A61K31/495 , C07D405/12
CPC分类号： C07D295/192 , A61K31/495 , A61K31/496 , C07D207/08 , C07D207/12 , C07D207/20 , C07D211/42 , C07D231/12 , C07D233/54 , C07D237/20 , C07D249/08 , C07D257/04 , C07D307/14 , C07D309/14
摘要： A compound of formula wherein the substituents are as described in the specification for the treatment of psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia, dementia and other diseases in which cognitive processes are impaired, such as attention deficit disorders or Alzheimer's disease.
摘要翻译： 式的化合物，其中取代基如治疗精神病，疼痛，记忆和学习中的神经变性功能障碍，精神分裂症，痴呆和其他认知过程受损的其他疾病（如注意力缺陷障碍或阿尔茨海默病）的治疗方法所述。
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公开(公告)号：US07462617B2
公开(公告)日：2008-12-09
申请号：US10933072
申请日：2004-09-01
申请人： Daniela Alberati-Giani , Synese Jolidon , Robert Narquizian , Matthias Heinrich Nettekoven , Roger David Norcross , Emmanuel Pinard , Henri Stalder
发明人： Daniela Alberati-Giani , Synese Jolidon , Robert Narquizian , Matthias Heinrich Nettekoven , Roger David Norcross , Emmanuel Pinard , Henri Stalder
IPC分类号： A61K31/53 , A61K31/496 , C07D295/192 , C07D409/12 , C07D251/22 , C07D251/24 , A61K31/495
CPC分类号： C07D295/16 , A61K31/495 , A61K31/496 , C07D213/56 , C07D213/69 , C07D213/74 , C07D233/64 , C07D239/26 , C07D239/42 , C07D241/12 , C07D251/42 , C07D251/48 , C07D257/04 , C07D263/32 , C07D277/30 , C07D295/185 , C07D309/04 , C07D309/20 , C07D333/24 , C07D409/12
摘要： The invention relates to compounds of formula wherein the substituents are as defined in the specification and to pharmaceutically acceptable acid addition salts thereof. The invention further relates to methods for the treatment of psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia, dementia and other d 1iseases in which cognitive processes are impaired, such as attention deficit disorders or Alzheimer's disease.
摘要翻译： 本发明涉及下式的化合物，其中取代基如说明书中所定义，及其药学上可接受的酸加成盐。 本发明还涉及用于治疗精神病，疼痛，记忆和学习中的神经变性功能障碍，精神分裂症，痴呆和其他认知过程受损的其他疾病的方法，例如注意力缺陷障碍或阿尔茨海默病。
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公开(公告)号：US07427612B2
公开(公告)日：2008-09-23
申请号：US10933103
申请日：2004-09-02
申请人： Daniela Alberati-Giani , Synese Jolidon , Robert Narquizian , Matthias Heinrich Nettekoven , Roger David Norcross , Emmanuel Pinard , Henri Stalder
发明人： Daniela Alberati-Giani , Synese Jolidon , Robert Narquizian , Matthias Heinrich Nettekoven , Roger David Norcross , Emmanuel Pinard , Henri Stalder
IPC分类号： A61K31/55 , A61K31/5377 , A61K31/496 , C07D295/192
CPC分类号： C07D295/192 , A61K31/495 , A61K31/496 , C07D207/08 , C07D207/12 , C07D207/20 , C07D211/42 , C07D231/12 , C07D233/54 , C07D237/20 , C07D249/08 , C07D257/04 , C07D307/14 , C07D309/14
摘要： A compound of formula wherein the substituents are as described in the specification for the treatment of psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia, dementia and other diseases in which cognitive processes are impaired, such as attention deficit disorders or Alzheimer's disease.
摘要翻译： 式的化合物，其中取代基如治疗精神病，疼痛，记忆和学习中的神经变性功能障碍，精神分裂症，痴呆和其他认知过程受损的其他疾病（如注意力缺陷障碍或阿尔茨海默氏病）的描述中所述。
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公开(公告)号：US20080119486A1
公开(公告)日：2008-05-22
申请号：US11931379
申请日：2007-10-31
申请人： Synese Jolidon , Robert Narquizian , Matthias Heinrich Nettekoven , Roger David Norcross , Emmanuel Pinard , Henri Stalder
发明人： Synese Jolidon , Robert Narquizian , Matthias Heinrich Nettekoven , Roger David Norcross , Emmanuel Pinard , Henri Stalder
IPC分类号： A61K31/495 , C07D295/03 , A61P25/18 , A61P25/28 , A61P25/00
CPC分类号： C07D239/42 , C07D213/85 , C07D241/20 , C07D251/42 , C07D257/04 , C07D263/32 , C07D271/06 , C07D295/192 , C07D309/12
摘要： The invention relates to compounds of formula wherein the substituents are described herein. The compounds may be used in the treatment of illnesses based on the glycine uptake inhibitor, such as psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia, dementia and other diseases in which cognitive processes are impaired, such as attention deficit disorders or Alzheimer's disease.
摘要翻译： 本发明涉及下式的化合物，其中取代基在本文中描述。 该化合物可用于基于甘氨酸摄取抑制剂治疗疾病，例如精神病，疼痛，记忆和学习中的神经变性功能障碍，精神分裂症，痴呆等认知过程受损的其他疾病，如注意力缺陷障碍或阿尔茨海默病 疾病。
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公开(公告)号：US07605163B2
公开(公告)日：2009-10-20
申请号：US11931379
申请日：2007-10-31
申请人： Synese Jolidon , Robert Narquizian , Matthias Heinrich Nettekoven , Roger David Norcross , Emmanuel Pinard , Henri Stalder
发明人： Synese Jolidon , Robert Narquizian , Matthias Heinrich Nettekoven , Roger David Norcross , Emmanuel Pinard , Henri Stalder
IPC分类号： A61K31/495 , C07D295/192
CPC分类号： C07D239/42 , C07D213/85 , C07D241/20 , C07D251/42 , C07D257/04 , C07D263/32 , C07D271/06 , C07D295/192 , C07D309/12
摘要： The invention relates to compounds of formula wherein the substituents are described herein. The compounds may be used in the treatment of illnesses based on the glycine uptake inhibitor, such as psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia, dementia and other diseases in which cognitive processes are impaired, such as attention deficit disorders or Alzheimer's disease.
摘要翻译： 本发明涉及下式的化合物，其中取代基在本文中描述。 该化合物可用于基于甘氨酸摄取抑制剂治疗疾病，例如精神病，疼痛，记忆和学习中的神经变性功能障碍，精神分裂症，痴呆等认知过程受损的其他疾病，如注意力缺陷障碍或阿尔茨海默氏症 疾病。
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公开(公告)号：US07485637B2
公开(公告)日：2009-02-03
申请号：US11302403
申请日：2005-12-13
IPC分类号： A61K31/535 , C07D413/10
CPC分类号： C07D211/70
摘要： The present invention relates to compounds of formula I wherein R1, R2, and Ar; are as defined in the specification. The invention also provides pharmaceutically acceptable acid addition salts thereof and methods for the treatment of neurological and neuropsychiatric disorders, such as schizophrenia, cognitive impairment, and Alzheimer's disease.
摘要翻译： 本发明涉及式I化合物，其中R1，R2和Ar; 如说明书中所定义。 本发明还提供其药学上可接受的酸加成盐以及用于治疗神经和神经精神疾病如精神分裂症，认知障碍和阿尔茨海默病的方法。
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公开(公告)号：US07375226B2
公开(公告)日：2008-05-20
申请号：US11297597
申请日：2005-12-08
IPC分类号： C07D495/04 , A61K31/4365
CPC分类号： C07D471/04 , C07D487/04 , C07D495/04 , C07D513/04
摘要： The present invention relates to compounds of formula IA wherein R1, R2, R3, and n are as defined in the specification, and to pharmaceutically active acid addition salts thereof. The compounds of the invention are useful in the treatment of neurological and neuropsychiatric disorders.
摘要翻译： 本发明涉及式IA化合物，其中R 1，R 2，R 3和n如说明书中所定义，和 其药物活性的酸加成盐。 本发明的化合物可用于治疗神经和神经精神障碍。
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10.发明授权公开(公告)号：US07241761B2
公开(公告)日：2007-07-10
申请号：US11291216
申请日：2005-12-01
IPC分类号： A61K31/496 , A61K31/5377 , C07D413/04 , C07D417/04 , C07D417/14 , A61K31/498 , C07D401/04 , C07D403/04
CPC分类号： C07D215/38 , C07D241/44 , C07D263/58 , C07D275/04 , C07D277/64 , C07D277/82
摘要： The present invention relates to compounds of the general formula I wherein R1 is the group and R2, R′, R″, R3, R4, R5, R6, R7, X1, X1′, X2, and N are as defined in the specification. Compounds of the invention are useful for the treatment of neurological and neuropsychiatric disorders.
摘要翻译： 本发明涉及通式I的化合物，其中R 1是基团，R 2，R'，R“，R 3 O， >，R 4，R 5，R 6，R 7，X 1，...，SUP >，X 1，X 2和N如说明书中所定义。 本发明的化合物可用于治疗神经和神经精神障碍。
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