公开(公告)号：US11805777B2

公开(公告)日：2023-11-07

申请号：US17934613

申请日：2022-09-23

Applicant: Syngenta Participations AG

Inventor： Christopher Fleming ,  Richard Sessler

IPC: C12N15/82 ,  C07K14/195 ,  A01N37/44 ,  A01H5/10 ,  A01N63/50

CPC classification number: A01N37/44 ,  A01H5/10 ,  A01N63/50 ,  C07K14/195 ,  C12N15/8286

Abstract: The invention provides nucleic acids, polypeptides, transgenic plants, compositions and methods for conferring pesticidal activity (e.g., insecticidal activity) to bacteria, plants, plant cells, tissues and seeds. Nucleic acids encoding the insecticidal proteins can be used to transform prokaryotic and eukaryotic organisms, including plants, to express the insecticidal proteins. The recombinant organisms and compositions containing the recombinant organisms or insecticidal proteins can be used to control a pest (e.g., an insect).

公开(公告)号：US12171227B2

公开(公告)日：2024-12-24

申请号：US18374347

申请日：2023-09-28

Applicant: Syngenta Participations AG

Inventor： Christopher Fleming ,  Richard Sessler

IPC: A01N37/44 ,  A01H5/10 ,  A01N63/50 ,  C07K14/195 ,  C12N15/82

Abstract: The invention provides nucleic acids, polypeptides, transgenic plants, compositions and methods for conferring pesticidal activity (e.g., insecticidal activity) to bacteria, plants, plant cells, tissues and seeds. Nucleic acids encoding the insecticidal proteins can be used to transform prokaryotic and eukaryotic organisms, including plants, to express the insecticidal proteins. The recombinant organisms and compositions containing the recombinant organisms or insecticidal proteins can be used to control a pest (e.g., an insect).

公开(公告)号：US20210190794A1

公开(公告)日：2021-06-24

申请号：US17271991

申请日：2019-08-14

Applicant: Syngenta Participations AG

Inventor： Scott Young ,  Richard Sessler ,  Gerson Graser ,  Rudolf Guilbaud ,  Michael Schirm ,  Maxim Isabelle

IPC: G01N33/68

Abstract: The invention relates generally to peptide biomarkers with specific ionization characteristics to directly quantify one or more transgenic target proteins in biological samples, including transgenic plant samples, by liquid chromatography coupled tandem mass spectrometry multiple reaction monitoring (MRM). The peptide biomarkers in combination with MRM-based methods may be used to quantify a single transgenic target protein or multiple transgenic target proteins within a stacked transgenic crop, such as maize, utilizing selected peptide biomarkers either alone or in combination. The present disclosure allows for broad based, reliable quantitation in different biological matrices, including plant matrices. The peptide biomarkers of the invention can further be used as trait biomarkers to support identification and/or selection of specific transgenic Events. Also provided are different peptide biomarker combinations that can be used to perform the methods of the invention.

公开(公告)号：US20170058008A1

公开(公告)日：2017-03-02

申请号：US15120563

申请日：2015-02-26

Applicant: SYNGENTA PARTICIPATIONS AG

Inventor： Renshui Liu ,  Milan Jucovic ,  Richard Sessler ,  Guo-Qing Tang ,  Jeng Shong Chen

IPC: C07K14/435 ,  G01N33/566 ,  C12N15/10 ,  A01N63/02 ,  A01N37/46

CPC classification number: C07K14/43563 ,  A01N37/46 ,  A01N63/02 ,  C12N9/14 ,  C12N15/1037 ,  C12N15/8286 ,  G01N33/566 ,  G01N33/68 ,  G01N2333/705 ,  G01N2430/10 ,  G01N2500/04 ,  Y02A40/162

Abstract: This invention provides polypeptides that were identified as interacting with Vip3 toxin. This invention also provides a method of identifying agents that bind to Vip3 interacting polypeptides, which agents may act as insecticidal agent, cytotoxic agents and/or modulate the activity of Vip3 interacting polypeptides.

Abstract translation: 本发明提供被鉴定为与Vip3毒素相互作用的多肽。 本发明还提供鉴定结合Vip3相互作用多肽的试剂的方法，所述试剂可以作为杀虫剂，细胞毒性剂和/或调节Vip3相互作用多肽的活性。

公开(公告)号：US20240049708A1

公开(公告)日：2024-02-15

申请号：US18374347

申请日：2023-09-28

Applicant: Syngenta Participations AG

Inventor： Christopher Fleming ,  Richard Sessler

IPC: A01N37/44 ,  A01H5/10 ,  C07K14/195 ,  C12N15/82 ,  A01N63/50

CPC classification number: A01N37/44 ,  A01H5/10 ,  C07K14/195 ,  C12N15/8286 ,  A01N63/50

Abstract: The invention provides nucleic acids, polypeptides, transgenic plants, compositions and methods for conferring pesticidal activity (e.g., insecticidal activity) to bacteria, plants, plant cells, tissues and seeds. Nucleic acids encoding the insecticidal proteins can be used to transform prokaryotic and eukaryotic organisms, including plants, to express the insecticidal proteins. The recombinant organisms and compositions containing the recombinant organisms or insecticidal proteins can be used to control a pest (e.g., an insect).

公开(公告)号：US11484030B2

公开(公告)日：2022-11-01

申请号：US16648323

申请日：2018-10-01

Applicant: Syngenta Participations AG

Inventor： Christopher Fleming ,  Richard Sessler

IPC: C07K14/195 ,  C12N15/82 ,  A01N37/44 ,  A01H1/02 ,  A01H5/10 ,  A01N63/50

Abstract: The invention provides nucleic acids, polypeptides, transgenic plants, compositions and methods for conferring pesticidal activity (e.g., insecticidal activity) to bacteria, plants, plant cells, tissues and seeds. Nucleic acids encoding the insecticidal proteins can be used to transform prokaryotic and eukaryotic organisms, including plants, to express the insecticidal proteins. The recombinant organisms and compositions containing the recombinant organisms or insecticidal proteins can be used to control a pest (e.g., an insect).