公开(公告)号：US20040266769A1

公开(公告)日：2004-12-30

申请号：US10803344

申请日：2004-03-17

申请人： Syrrx, Inc.

发明人： Jerome C. Bressi ,  Jason W. Brown ,  Sheldon X. Cao ,  Anthony R. Gangloff ,  Andrew J. Jennings ,  Jeffrey A. Stafford ,  Phong H. Vu ,  Xiao-Yi Xiao

IPC分类号： A61K031/535 ,  A61K031/53 ,  A61K031/52 ,  A61K031/519

CPC分类号： C07D235/18 ,  C07D401/04 ,  C07D401/06 ,  C07D403/06 ,  C07D403/10

摘要： Compounds that may be used to inhibit histone deacetylase having the formula Z-Q-L-M or Z-L-M wherein M is a substituent capable of complexing with a deacetylase catalytic site and/or a metal ion; L is a substituent providing between 0-10 atoms separation between the M substituent and the remainder of the compound; and Z and Q are as defined herein.

公开(公告)号：US20040254220A1

公开(公告)日：2004-12-16

申请号：US10803575

申请日：2004-03-17

申请人： Syrrx, Inc.

发明人： Jerome C. Bressi ,  Jason W. Brown ,  Sheldon X. Cao ,  Anthony R. Gangloff ,  Andrew J. Jennings ,  Jeffrey A. Stafford ,  Phong H. Vu ,  Xiao-Yi Xiao

IPC分类号： A61K031/454 ,  C07D43/04

CPC分类号： C07D235/18 ,  C07D401/04 ,  C07D401/06 ,  C07D403/06 ,  C07D403/10

摘要： Compounds that may be used to inhibit histone deacetylase having the formula Z-Q-L-M or Z-L-M wherein M is a substituent capable of complexing with a deacetylase catalytic site and/or a metal ion; L is a substituent providing between 0-10 atoms separation between the M substituent and the remainder of the compound; and Z and Q are as defined herein.

摘要翻译： 可用于抑制具有式Z-Q-L-M或Z-L-M的组蛋白脱乙酰酶的化合物，其中M是能够与脱乙酰酶催化位点和/或金属离子络合的取代基; L是在M取代基和化合物的其余部分之间分离0-10个原子之间的取代基; Z和Q如本文所定义。