公开(公告)号：US20170059592A1

公开(公告)日：2017-03-02

申请号：US15242739

申请日：2016-08-22

Applicant: SYSMEX CORPORATION

Inventor： Yuhgi SUZUKI

IPC: G01N33/80 ,  G01N21/64 ,  G01N1/30

CPC classification number: G01N33/80 ,  G01N1/30 ,  G01N21/6428 ,  G01N33/56905 ,  G01N2001/302 ,  G01N2021/6439 ,  G01N2201/0612 ,  G01N2333/445 ,  G01N2800/26 ,  Y02A50/58

Abstract: Disclosed is a blood analyzing method including: a step of preparing a measurement sample from blood, a fluorescent dye represented by the following formula 1, and a diluent, a concentration of the fluorescent dye in the measurement sample being greater than or equal to 0.15 μM and smaller than or equal to 1.0 μM; a step of acquiring fluorescence information obtained by irradiating the measurement sample with light; and a step of detecting a red blood cell infected with a malaria parasite in the blood based on the fluorescence information.

Abstract translation: 公开了一种血液分析方法，包括：从血液制备测定样品，由下式1表示的荧光染料和稀释剂，测定样品中荧光染料的浓度大于或等于0.15μM 小于或等于1.0μM; 获取通过用光照射测量样品获得的荧光信息的步骤; 以及基于荧光信息检测血液中的疟原虫感染的红细胞的步骤。

公开(公告)号：US20150185210A1

公开(公告)日：2015-07-02

申请号：US14590551

申请日：2015-01-06

Applicant: SYSMEX CORPORATION

Inventor： Yuhgi SUZUKI ,  Keiko MORIYAMA ,  Yusuke MORI ,  Hiroki TAKESHITA

IPC: G01N33/52

CPC classification number: G01N33/80 ,  G01N33/52

Abstract: A reagent for measuring platelets comprising Nile Blue hydrogensulfate, or Nile Blue and an acid, a reagent kit for measuring platelets comprising the reagent for measuring platelets, and a method for measuring platelets using the reagent or reagent kit.

Abstract translation: 一种用于测量血小板的试剂，其包含尼罗蓝硫酸氢盐或尼罗蓝和酸，用于测量血小板的试剂盒，其包含用于测量血小板的试剂，以及使用该试剂或试剂盒测定血小板的方法。

公开(公告)号：US20200025778A1

公开(公告)日：2020-01-23

申请号：US16585982

申请日：2019-09-27

Applicant: Sysmex Corporation

Inventor： Yuhgi SUZUKI ,  Takuma WATANABE

IPC: G01N33/80 ,  C12Q1/06 ,  G01N15/14 ,  G01N33/569 ,  G01N1/30 ,  G01N21/64

Abstract: Disclosed is a blood analyzer that includes: a sample preparation unit configured to mix a blood specimen and a fluorescent dye for staining nucleic acid to prepare a measurement sample; a light receiver configured to receive fluorescence and scattered light that are generated by light being applied to the measurement sample prepared by the sample preparation unit; and a controller programmed to determine whether or not infection with Plasmodium has occurred, on the basis of a value representing variation of a distribution of first particles in a range where single-ring form of red blood cells appear, the range where single-ring form of red blood cells appear being identified according to fluorescence intensities and scattered light intensities obtained by processing of signals from the light receiver.

公开(公告)号：US20160282346A1

公开(公告)日：2016-09-29

申请号：US15081206

申请日：2016-03-25

Applicant: Sysmex Corporation

Inventor： Yuhgi SUZUKI ,  Nozomu HIGUCHI

IPC: G01N33/569 ,  G01N1/34

CPC classification number: G01N33/56972 ,  G01N1/34 ,  G01N15/1459 ,  G01N33/4915 ,  G01N33/5094 ,  G01N2015/008 ,  G01N2015/1006 ,  G01N2015/1402 ,  G01N2015/1477 ,  G01N2015/1486 ,  G01N2333/70503 ,  G01N2333/7051 ,  G01N2333/70514 ,  G01N2333/70589 ,  G01N2800/56 ,  Y02A50/58

Abstract: A blood analyzer including a specimen preparation unit, a flow cell, a light source unit, light receivers, and a processing unit. The processing unit is configured to identify and count lymphocytes in the first measurement specimen by using first scattered light information based on the first scattered light and second scattered light information based on the second scattered light, and configured to identify and count blood cells having thereon the predetermined surface antigen in the first measurement specimen by using first fluorescence information based on the first fluorescence.

Abstract translation: 一种血液分析仪，包括样本制备单元，流动池，光源单元，光接收器和处理单元。 该处理单元通过使用基于第一散射光的第一散射光信息和基于第二散射光的第二散射光信息来识别并计数第一测定样本中的淋巴细胞，并且构成为， 通过使用基于第一荧光的第一荧光信息来确定第一测量样本中的预定表面抗原。

公开(公告)号：US20180024148A1

公开(公告)日：2018-01-25

申请号：US15657962

申请日：2017-07-24

Applicant: Sysmex Corporation

Inventor： Yuhgi SUZUKI ,  Takuma WATANABE

IPC: G01N33/80 ,  G01N1/30 ,  G01N21/64

CPC classification number: G01N33/80 ,  C12Q1/06 ,  G01N1/30 ,  G01N15/1429 ,  G01N15/1456 ,  G01N15/1459 ,  G01N21/6428 ,  G01N33/56905 ,  G01N2015/0073 ,  G01N2015/1006 ,  G01N2015/1402 ,  G01N2015/1497 ,  G01N2021/6439 ,  G01N2333/445 ,  Y02A50/58

Abstract: Disclosed is a blood analyzer that includes: a sample preparation unit configured to mix a blood specimen and a fluorescent dye for staining nucleic acid to prepare a measurement sample; a light receiver configured to receive fluorescence and scattered light that are generated by light being applied to the measurement sample prepared by the sample preparation unit; and a controller programmed to determine whether or not infection with Plasmodium has occurred, on the basis of a value representing variation of a distribution of first particles in a range where single-ring form of red blood cells appear, the range where single-ring form of red blood cells appear being identified according to fluorescence intensities and scattered light intensities obtained by processing of signals from the light receiver.

公开(公告)号：US20170059486A1

公开(公告)日：2017-03-02

申请号：US15250168

申请日：2016-08-29

Applicant: Sysmex Corporation

Inventor： Yuhgi SUZUKI ,  Munehisa IZUKA ,  Konobu KIMURA

IPC: G01N21/64 ,  G01N15/06 ,  G01N21/47 ,  G01N1/30

CPC classification number: G01N21/6428 ,  G01N1/30 ,  G01N15/06 ,  G01N15/147 ,  G01N21/47 ,  G01N33/4915 ,  G01N33/5091 ,  G01N33/5094 ,  G01N33/582 ,  G01N2001/302 ,  G01N2015/0065 ,  G01N2015/0073 ,  G01N2015/0693 ,  G01N2015/1037 ,  G01N2015/1402 ,  G01N2015/1477 ,  G01N2015/1486 ,  G01N2015/1488 ,  G01N2015/1493 ,  G01N2021/4707 ,  G01N2021/6439 ,  G01N2201/0612 ,  G01N2201/12 ,  G01N2333/445

Abstract: A blood analyzer comprises a sample preparing part configured to prepare a measurement sample from a blood sample, an staining dye and diluent, a detecting part configured to detect the fluorescent light intensity and the scattered light intensity, an output part, and an analyzing part configured to identify the population including red blood cells infected by ring-form malaria parasite based on the fluorescent light intensity and the scattered light intensity, and output to the output part the information relating to infection of Plasmodium falciparum based on the scattered light distribution of particles associated with the identified population that includes red blood cells infected by the ring-form malaria parasite.

Abstract translation: 一种血液分析装置，其特征在于，包括：样本制备部，其构成为从血液样品，染色染料和稀释剂制备测定样品，被配置为检测荧光强度和散射光强度的检测部，输出部，以及分析部 基于荧光强度和散射光强度鉴定包括由环状疟原虫感染的红细胞的群体，并且基于与颗粒相关的散射光分布将与恶性疟原虫感染相关的信息输出到输出部分 识别的人群包括被环状疟原虫感染的红细胞。