公开(公告)号：US20070244189A1

公开(公告)日：2007-10-18

申请号：US11578849

申请日：2005-12-27

申请人： Syuichi Fukumoto ,  Kazutaka Tsuruhami ,  Shigeharu Mori

发明人： Syuichi Fukumoto ,  Kazutaka Tsuruhami ,  Shigeharu Mori

IPC分类号： A61K31/35

CPC分类号： A23L3/3472 ,  A23L2/44 ,  A23L2/52 ,  C07D311/32 ,  C12P17/06

摘要： An antioxidant material of the present invention contains flavonoid aglycon and vitamin C. The flavonoid aglycon is eriodictyol and/or diosmetin obtained by treatment of a raw material containing flavonoid glycoside derived from lemons, limes, or sudachis to form the aglycones thereof. It is preferred that this antioxidant material be produced through a step of mixing the flavonoid aglycon and the vitamin C after the treatment to form the aglycones. The treatment to form the aglycones is glycosidase treatment using a β-glycosidase derived from a microorganism of the genus Aspergillus or Penicillium multicolor, or microbial fermentative treatment using a microorganism of the genus Aspergillus. An anti-deterioration agent and a food or beverage of the present invention contain the antioxidant material.

摘要翻译： 本发明的抗氧化剂材料含有类黄酮糖苷配基和维生素C.所述黄酮糖苷配基是通过处理含有衍生自柠檬，酸橙或皂草的类黄酮糖苷的原料而形成的二碘酪蛋白和/或脱水甜菜蛋白，以形成其糖苷配基。 优选通过在处理后混合类黄酮苷元和维生素C以形成糖苷配基的步骤来制备该抗氧化剂材料。 形成糖苷配基的处理是使用衍生自曲霉属微生物或多色青霉菌的β-糖苷酶进行糖苷酶处理，或使用曲霉属微生物的微生物发酵处理。 本发明的防变质剂，食品或饮料含有抗氧化剂材料。

公开(公告)号：US08247002B2

公开(公告)日：2012-08-21

申请号：US12379742

申请日：2009-02-27

申请人： Syuichi Fukumoto ,  Kazutaka Tsuruhami ,  Shigeharu Mori

发明人： Syuichi Fukumoto ,  Kazutaka Tsuruhami ,  Shigeharu Mori

IPC分类号： A61K36/00 ,  A61K36/752

CPC分类号： A23L3/3472 ,  A23L2/44 ,  A23L2/52 ,  C07D311/32 ,  C12P17/06

摘要： An antioxidant material of the present invention contains flavonoid aglycon and vitamin C. The flavonoid aglycon is eriodictyol and/or diosmetin obtained by treatment of a raw material containing flavonoid glycoside derived from lemons, limes, or sudachis to form the aglycones thereof. It is preferred that this antioxidant material be produced through a step of mixing the flavonoid aglycon and the vitamin C after the treatment to form the aglycones. The treatment to form the aglycones is glycosidase treatment using a β-glycosidase derived from a microorganism of the genus Aspergillus or Penicillium multicolor, or microbial fermentative treatment using a microorganism of the genus Aspergillus. An anti-deterioration agent and a food or beverage of the present invention contain the antioxidant material.

摘要翻译： 本发明的抗氧化剂材料含有类黄酮糖苷配基和维生素C.所述黄酮糖苷配基是通过处理含有衍生自柠檬，酸橙或皂草的类黄酮糖苷的原料而形成的二碘酪蛋白和/或脱水甜菜蛋白，以形成其糖苷配基。 优选通过在处理后混合类黄酮苷元和维生素C以形成糖苷配基的步骤来制备该抗氧化剂材料。 用于形成糖苷配基的处理是使用衍生自曲霉属微生物或多色青霉菌的β-糖苷酶进行糖苷酶处理，或使用曲霉属微生物的微生物发酵处理。 本发明的防变质剂，食品或饮料含有抗氧化剂材料。

公开(公告)号：US20090175996A1

公开(公告)日：2009-07-09

申请号：US12379742

申请日：2009-02-27

申请人： Syuichi Fukumoto ,  Kazutaka Tsuruhami ,  Shigeharu Mori

发明人： Syuichi Fukumoto ,  Kazutaka Tsuruhami ,  Shigeharu Mori

IPC分类号： A23L3/3544 ,  C12P17/06 ,  C12P17/16 ,  A23L2/44 ,  C09K15/06

CPC分类号： A23L3/3472 ,  A23L2/44 ,  A23L2/52 ,  C07D311/32 ,  C12P17/06

摘要： An antioxidant material of the present invention contains flavonoid aglycon and vitamin C. The flavonoid aglycon is eriodictyol and/or diosmetin obtained by treatment of a raw material containing flavonoid glycoside derived from lemons, limes, or sudachis to form the aglycones thereof. It is preferred that this antioxidant material be produced through a step of mixing the flavonoid aglycon and the vitamin C after the treatment to form the aglycones. The treatment to form the aglycones is glycosidase treatment using a β-glycosidase derived from a microorganism of the genus Aspergillus or Penicillium multicolor, or microbial fermentative treatment using a microorganism of the genus Aspergillus. An anti-deterioration agent and a food or beverage of the present invention contain the antioxidant material.

摘要翻译： 本发明的抗氧化剂材料含有类黄酮糖苷配基和维生素C.所述黄酮糖苷配基是通过处理含有衍生自柠檬，酸橙或皂草的类黄酮糖苷的原料而形成的二碘酪蛋白和/或脱水甜菜蛋白，以形成其糖苷配基。 优选通过在处理后混合类黄酮苷元和维生素C以形成糖苷配基的步骤来制备该抗氧化剂材料。 形成糖苷配基的处理是使用衍生自曲霉属微生物或多色青霉菌的β-糖苷酶进行糖苷酶处理，或使用曲霉属微生物的微生物发酵处理。 本发明的防变质剂，食品或饮料含有抗氧化剂材料。

公开(公告)号：US07829591B2

公开(公告)日：2010-11-09

申请号：US11686038

申请日：2007-03-14

申请人： Shigenori Kumazawa ,  Tsutomu Nakayama ,  Kayoko Shimoi ,  Takaki Goto ,  Syuichi Fukumoto ,  Tsutomu Arakaki

发明人： Shigenori Kumazawa ,  Tsutomu Nakayama ,  Kayoko Shimoi ,  Takaki Goto ,  Syuichi Fukumoto ,  Tsutomu Arakaki

IPC分类号： A61K31/353 ,  C07D311/74

CPC分类号： A61Q17/005 ,  A23L33/105 ,  A61K8/498 ,  A61K2800/522 ,  A61Q19/00 ,  C07D311/34 ,  C09K15/08

摘要： Each of an antioxidant, an antimicrobial agent, an antitumor agent, a food and beverage product, cosmetics, a quasi-drug and a pharmaceutical of the present invention contains a new flavanone compound represented by the following structural formula: Alternatively, each of an antioxidant, an antimicrobial agent, an antitumor agent, a food and beverage product, cosmetics, a quasi-drug and a pharmaceutical of the present invention contains at least one flavanone compound selected from the group consisting of nymphaeol-A, nymphaeol-B, and nymphaeol-C.

摘要翻译： 本发明的抗氧化剂，抗微生物剂，抗肿瘤剂，食品饮品，化妆品，准药和药物中的每一种都含有由以下结构式表示的新的黄烷酮化合物：或者，各抗氧化剂 本发明的抗微生物剂，抗肿瘤剂，食品和饮料产品，化妆品，准药物和药物中含有至少一种选自下列药物的黄烷酮化合物：尼莫酚-A，宁波醇B和宁波酚 -C。

公开(公告)号：US20070161579A1

公开(公告)日：2007-07-12

申请号：US11686038

申请日：2007-03-14

申请人： Shigenori Kumazawa ,  Tsutomu Nakayama ,  Kayoko Shimoi ,  Takaki Goto ,  Syuichi Fukumoto ,  Tsutomu Arakaki

发明人： Shigenori Kumazawa ,  Tsutomu Nakayama ,  Kayoko Shimoi ,  Takaki Goto ,  Syuichi Fukumoto ,  Tsutomu Arakaki

IPC分类号： A61K31/7048 ,  A61K31/353 ,  A61K47/00 ,  A61K8/73

CPC分类号： A61Q17/005 ,  A23L33/105 ,  A61K8/498 ,  A61K2800/522 ,  A61Q19/00 ,  C07D311/34 ,  C09K15/08

摘要： Each of an antioxidant, an antimicrobial agent, an antitumor agent, a food and beverage product, cosmetics, a quasi-drug and a pharmaceutical of the present invention contains a new flavanone compound represented by the following structural formula: Alternatively, each of an antioxidant, an antimicrobial agent, an antitumor agent, a food and beverage product, cosmetics, a quasi-drug and a pharmaceutical of the present invention contains at least one flavanone compound selected from the group consisting of nymphaeol-A, nymphaeol-B, and nymphaeol-C.

摘要翻译： 本发明的抗氧化剂，抗微生物剂，抗肿瘤剂，食品饮品，化妆品，准药和药物中的每一种都含有由以下结构式表示的新的黄烷酮化合物：或者，各抗氧化剂 本发明的抗微生物剂，抗肿瘤剂，食品和饮料产品，化妆品，准药物和药物中含有至少一种选自下列药物的黄烷酮化合物：尼莫酚-A，宁波醇B和宁波酚 -C。

公开(公告)号：US20110015411A1

公开(公告)日：2011-01-20

申请号：US12921554

申请日：2009-02-26

申请人： Takaki Goto ,  Syuichi Fukumoto

发明人： Takaki Goto ,  Syuichi Fukumoto

IPC分类号： C07D311/32

CPC分类号： A01N65/18 ,  A01N43/16 ,  A01N65/00 ,  A61K8/97 ,  A61K31/352 ,  A61K36/47 ,  A61K2800/524 ,  A61Q19/10 ,  Y02A50/478

摘要： A growth inhibitor of bacteria of the genus Legionella contains as an active ingredient a Macaranga tanarius extract extracted from Macaranga tanarius with an extraction solvent including at least an organic solvent. Alternatively, the growth inhibitor of bacteria of the genus Legionella contains as an active ingredient at least one selected from nymphaeol-A, nymphaeol-B, and nymphaeol-C. The growth inhibitor of bacteria of the genus Legionella is used by being blended to, for example, a bath agent or a cleaning agent.

摘要翻译： 军团菌细菌的生长抑制剂含有从马齿苋（Macaranga tanarius）中萃取的含有至少一种有机溶剂的萃取溶剂作为活性成分。 或者，军团菌细菌的生长抑制剂含有选自淋巴酮-A，夜蛾酚B和夜蛾酚C中的至少一种作为活性成分。 通过与例如浴剂或清洁剂混合使用军团菌属细菌的生长抑制剂。

公开(公告)号：US20110008472A1

公开(公告)日：2011-01-13

申请号：US12921560

申请日：2009-02-26

申请人： Takaki Goto ,  Syuichi Fukumoto

发明人： Takaki Goto ,  Syuichi Fukumoto

IPC分类号： A61K36/47 ,  A61K31/353 ,  A61P31/04

CPC分类号： A01N65/18 ,  A01N65/00 ,  A61K31/353 ,  A61K36/47 ,  C07D311/32

摘要： An anti-methicillin-resistant Staphylococcus aureus agent (anti-MRSA agent) and an anti-vancomycin-resistant Enterococcus agent (anti-VRE agent) contain as an active ingredient an Oobagi extract extracted from Oobagi with an extraction solvent including at least an organic solvent. Alternatively, the anti-MRSA agent and the anti-VRE agent contain as an active ingredient at least one selected from nymphaeol-A, nymphaeol-B, and nymphaeol-C.

摘要翻译： 含抗甲氧西林抗性金黄色葡萄球菌剂（抗MRSA试剂）和抗万古霉素耐药性肠球菌剂（anti-VRE试剂）含有从Oobagi提取的Oobagi提取物作为活性成分，提取溶剂包括至少一种有机 溶剂。 或者，抗MRSA试剂和抗VRE试剂含有选自淋巴酮-A，夜蛾B和睡莲C中的至少一种作为活性成分。

公开(公告)号：US07256214B2

公开(公告)日：2007-08-14

申请号：US10562019

申请日：2004-06-18

申请人： Shigenori Kumazawa ,  Tsutomu Nakayama ,  Kayoko Shimoi ,  Takaki Goto ,  Syuichi Fukumoto ,  Tsutomu Arakaki

发明人： Shigenori Kumazawa ,  Tsutomu Nakayama ,  Kayoko Shimoi ,  Takaki Goto ,  Syuichi Fukumoto ,  Tsutomu Arakaki

IPC分类号： A61K31/352 ,  C09K15/08 ,  C07D311/32

CPC分类号： A61Q17/005 ,  A23L33/105 ,  A61K8/498 ,  A61K2800/522 ,  A61Q19/00 ,  C07D311/34 ,  C09K15/08

摘要： Each of an antioxidant, an antimicrobial agent, an antitumor agent, a food and beverage product, cosmetics, a quasi-drug and a pharmaceutical of the present invention contains a new flavanone compound represented by the following structural formula: Alternatively, each of an antioxidant, an antimicrobial agent, an antitumor agent, a food and beverage product, cosmetics, a quasi-drug and a pharmaceutical of the present invention contains at least one flavanone compound selected from the group consisting of nymphaeol-A, nymphaeol-B, and nymphaeol-C.

摘要翻译： 本发明的抗氧化剂，抗微生物剂，抗肿瘤剂，食品饮品，化妆品，准药和药物中的每一种都含有由以下结构式表示的新的黄烷酮化合物：或者，各抗氧化剂 本发明的抗微生物剂，抗肿瘤剂，食品和饮料产品，化妆品，准药物和药物中含有至少一种选自下列药物的黄烷酮化合物：尼莫酚-A，宁波醇B和宁波酚 -C。

公开(公告)号：US20060292204A1

公开(公告)日：2006-12-28

申请号：US10562019

申请日：2004-06-18

申请人： Shigenori Kumazawa ,  Tsutomu Nakayama ,  Kayoko Shimoi ,  Takaki Goto ,  Syuichi Fukumoto ,  Tsutomu Arakaki

发明人： Shigenori Kumazawa ,  Tsutomu Nakayama ,  Kayoko Shimoi ,  Takaki Goto ,  Syuichi Fukumoto ,  Tsutomu Arakaki

IPC分类号： A61K31/353 ,  A61K47/00 ,  C07D311/02

CPC分类号： A61Q17/005 ,  A23L33/105 ,  A61K8/498 ,  A61K2800/522 ,  A61Q19/00 ,  C07D311/34 ,  C09K15/08

摘要： Each of an antioxidant, an antimicrobial agent, an antitumor agent, a food and beverage product, cosmetics, a quasi-drug and a pharmaceutical of the present invention contains a new flavanone compound represented by the following structural formula: Alternatively, each of an antioxidant, an antimicrobial agent, an antitumor agent, a food and beverage product, cosmetics, a quasi-drug and a pharmaceutical of the present invention contains at least one flavanone compound selected from the group consisting of nymphaeol-A, nymphaeol-B, and nymphaeol-C.

摘要翻译： 本发明的抗氧化剂，抗微生物剂，抗肿瘤剂，食品饮品，化妆品，准药和药物中的每一种都含有由以下结构式表示的新的黄烷酮化合物：或者，各抗氧化剂 本发明的抗微生物剂，抗肿瘤剂，食品和饮料产品，化妆品，准药物和药物中含有至少一种选自下列药物的黄烷酮化合物：尼莫酚-A，宁波醇B和宁波酚 -C。

公开(公告)号：US08603548B2

公开(公告)日：2013-12-10

申请号：US13122709

申请日：2009-10-08

申请人： Syuichi Fukumoto ,  Kenji Kumagai ,  Yasuo Suzuki ,  Nongluk Sriwilaijaroen

发明人： Syuichi Fukumoto ,  Kenji Kumagai ,  Yasuo Suzuki ,  Nongluk Sriwilaijaroen

IPC分类号： A61K36/00

CPC分类号： A61K36/61

摘要： An anti-avian influenza virus agent containing, as an active ingredient, a component obtained when a guava extract extracted from a guava with an extraction solvent consisting primarily of at least one of water and a hydrophilic organic solvent is subjected to fractionation by HPLC under specific conditions. The specific conditions include the use of an ODS column, the use of a water-methanol mixture having a methanol concentration of 20% as a mobile phase during a period until 15 minutes after applying the guava extract to the column, and the use of a water-methanol mixture having a methanol concentration of 40% as a mobile phase during a subsequent period of 15 to 30 minutes. Alternatively, the specific conditions further include the use of a water-methanol mixture having a methanol concentration of 60% as a mobile phase during a period of 30 to 45 minutes after applying the guava extract to the column. The component contained in the anti-avian influenza virus agent is eluted from the column in a period until 20 minutes after applying the guava extract to the column or in a subsequent period of 20 to 35 minutes.

摘要翻译： 含有主要由水和亲水性有机溶剂中的至少一种构成的提取溶剂的番石榴提取物的番石榴提取物作为有效成分的抗禽流感病毒剂，在特定的条件下进行HPLC分级 条件。 特定条件包括使用ODS柱，在将番石榴提取物施用于塔后15分钟内使用甲醇浓度为20％的水 - 甲醇混合物作为流动相，并使用 在随后的15-30分钟内，甲醇浓度为40％的水 - 甲醇混合物作为流动相。 或者，具体条件还包括在将番石榴提取物施用于塔后，在30至45分钟的时间内使用甲醇浓度为60％的水 - 甲醇混合物作为流动相。 包含在抗禽流感病毒剂中的组分在将番石榴提取物施用于柱后或在随后的20至35分钟的时间段内直到20分钟从柱中洗脱出来。