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公开(公告)号:US20160176872A1
公开(公告)日:2016-06-23
申请号:US15055108
申请日:2016-02-26
Applicant: Takeda Pharmaceutical Company Limited
Inventor: Satoshi YAMAMOTO , Junya SHIRAI , Tsuneo ODA , Mitsunori KONO , Atsuko OCHIDA , Takashi IMADA , Hidekazu TOKUHARA , Yoshihide TOMATA , Naoki ISHII , Michiko TAWADA , Yoshiyuki FUKASE , Tomoya YUKAWA , Shoji FUKUMOTO
IPC: C07D471/04
CPC classification number: C07D217/26 , A61K31/4375 , A61K31/472 , A61K31/4741 , C07D217/14 , C07D471/04 , C07D491/048 , C07D491/056 , C07D491/14 , C07F7/0812
Abstract: The present invention provides a heterocyclic compound having a RORγt inhibitory action.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification. or a salt thereof.
Abstract translation: 本发明提供具有RORγt抑制作用的杂环化合物。 本发明涉及由式(I)表示的化合物:其中每个符号如说明书中所定义。 或其盐。
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公开(公告)号:US20240217957A1
公开(公告)日:2024-07-04
申请号:US18522917
申请日:2023-11-29
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor: Asato KINA , Zenichi IKEDA , Mitsunori KONO , Yuya OGURO , Osamu KUBO , Toru YAMASHITA , Kazuaki TAKAMI , Takafumi YUKAWA , Masaki SETO , Makoto KAMATA , Kenjiro SATO , Masataka MURAKAMI , Yusuke SASAKI , Matthew Thomas REYNOLDS , Minoru NAKAMURA , Taku KAMEI , Hiroyuki KAKEI , Fumie YAMAGUCHI , Tomohiro OHASHI , Takuto KOJIMA , Keiko KAKEGAWA , Florian PÜNNER , Shinji NAKAMURA , Nao MORISHITA , Tadashi HIDAKA , Sachie TAKASHIMA , Takahiko TANIGUCHI
IPC: C07D413/04 , A61P25/00 , C07D413/14
CPC classification number: C07D413/04 , A61P25/00 , C07D413/14
Abstract: The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity. Provided is a compound of formula (I):
wherein each symbol is as described in the specification, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.-
3.
公开(公告)号:US20170144973A1
公开(公告)日:2017-05-25
申请号:US15321609
申请日:2015-06-30
Applicant: Takeda Pharmaceutical Company Limited
Inventor: Satoshi YAMAMOTO , Junya SHIRAI , Tsuneo ODA , Mitsunori KONO , Atsuko OCHIDA , Takashi IMADA , Hidekazu TOKUHARA , Yoshihide TOMATA , Naoki ISHII , Michiko TAWADA , Yoshiyuki FUKASE , Tomoya YUKAWA , Shoji FUKUMOTO
IPC: C07D217/26 , C07D491/056 , C07D491/048 , C07F7/08 , C07D471/04
CPC classification number: C07D217/26 , A61K31/4375 , A61K31/472 , A61K31/4741 , C07D217/14 , C07D471/04 , C07D491/048 , C07D491/056 , C07D491/14 , C07F7/0812
Abstract: Provided are heterocyclic compounds having a RORγt inhibitory action represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.
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公开(公告)号:US20160176873A1
公开(公告)日:2016-06-23
申请号:US15055156
申请日:2016-02-26
Applicant: Takeda Pharmaceutical Company Limited
Inventor: Satoshi YAMAMOTO , Junya SHIRAI , Tsuneo ODA , Mitsunori KONO , Atsuko OCHIDA , Takashi IMADA , Hidekazu TOKUHARA , Yoshihide TOMATA , Naoki ISHII , Michiko TAWADA , Yoshiyuki FUKASE , Tomoya YUKAWA , Shoji FUKUMOTO
IPC: C07D471/04
CPC classification number: C07D217/26 , A61K31/4375 , A61K31/472 , A61K31/4741 , C07D217/14 , C07D471/04 , C07D491/048 , C07D491/056 , C07D491/14 , C07F7/0812
Abstract: The present invention provides a heterocyclic compound having a RORγt inhibitory action.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification. or a salt thereof.
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公开(公告)号:US20160176822A1
公开(公告)日:2016-06-23
申请号:US15055197
申请日:2016-02-26
Applicant: Takeda Pharmaceutical Company Limited
Inventor: Satoshi YAMAMOTO , Junya SHIRAI , Tsuneo ODA , Mitsunori KONO , Atsuko OCHIDA , Takashi IMADA , Hidekazu TOKUHARA , Yoshihide TOMATA , Naoki ISHII , Michiko TAWADA , Yoshiyuki FUKASE , Tomoya YUKAWA , Shoji FUKUMOTO
IPC: C07D217/26
CPC classification number: C07D217/26 , A61K31/4375 , A61K31/472 , A61K31/4741 , C07D217/14 , C07D471/04 , C07D491/048 , C07D491/056 , C07D491/14 , C07F7/0812
Abstract: The present invention provides a heterocyclic compound having a RORγt inhibitory action.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification. or a salt thereof.
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公开(公告)号:US20240309016A1
公开(公告)日:2024-09-19
申请号:US18606857
申请日:2024-03-15
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor: Mitsunori KONO , Yusuke SASAKI , Yuya OGURO , Zenichi IKEDA , Osamu KUBO , Masaki SETO , Toru YAMASHITA , Makoto KAMATA , Kenjiro SATO , Matthew Thomas REYNOLDS , Kazuaki TAKAMI , Asato KINA , Takafumi YUKAWA , Minoru NAKAMURA , Taku KAMEI , Hiroyuki KAKEI , Fumie YAMAGUCHI , Tomohiro OHASHI , Keiko KAKEGAWA , Takuto KOJIMA , Florian PÜNNER , Masataka MURAKAMI , Takahiko TANIGUCHI , Tatsuki KOIKE , Yuichi KAJITA , Yuhei MIYANOHANA , Kohei TAKEUCHI , Yoshiteru ITO , Norihito TOKUNAGA , Yasushi HATTORI , Eiji KIMURA , Martin Alexander PAWLICZEK , Marilena PIRA , Shuhei IKEDA , Noriyuki TEZUKA , Yoshikazu WATANABE , Kevin CURRAN , Nicolle DOERING , Maria HOPKINS , Ben JOHNSON , Andre KIRYANOV , Jon LAM , Sean MURPHY , Natasha O'ROURKE , Holly REICHARD , Paul TANIS , Yunlong ZHANG
IPC: C07D498/14 , A61K31/407 , A61K31/437 , A61P25/26 , C07D498/04
CPC classification number: C07D498/14 , A61K31/407 , A61K31/437 , A61P25/26 , C07D498/04
Abstract: The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I):
wherein each symbol is as described in the specification, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.-
公开(公告)号:US20170253591A1
公开(公告)日:2017-09-07
申请号:US15510225
申请日:2015-09-10
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor: Satoshi YAMAMOTO , Junya SHIRAI , Tsuneo ODA , Takashi IMADA , Mitsunori KONO , Ayumu SATO , Yoshihide TOMATA , Atsuko OCHIDA , Naoki ISHII , Yusuke SASAKI , Yoshiyuki FUKASE , Tomoya YUKAWA , Shoji FUKUMOTO
IPC: C07D471/04 , C07D413/12 , C07D405/12 , C07D405/14 , C07D417/12 , C07D239/96 , C07D409/14 , C07D403/12 , C07D401/12 , C07D417/14 , C07D401/14 , C07D413/14
CPC classification number: C07D471/04 , A61K31/517 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/551 , A61P1/00 , A61P11/00 , C07D239/96 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
Abstract: The problem of the present invention is to provide a compound having a superior RORγt inhibitory action, and useful as a prophylactic or therapeutic agent for psoriasis, inflammatory bowel disease, ulcerative colitis, Crohn's disease, rheumatoid arthritis, multiple sclerosis, uveitis, asthma, ankylopoietic spondylarthritis, systemic lupus erythematosus, chronic obstructive pulmonary disease or the like. The present invention relates to a compound represented by the formula (I): [wherein each symbol is as described in the DESCRIPTION] or a salt thereof, which has an RORγt inhibitory action, and useful as a prophylactic or therapeutic agent for psoriasis, inflammatory bowel disease, ulcerative colitis, Crohn's disease, rheumatoid arthritis, multiple sclerosis, uveitis, asthma, ankylopoietic spondylarthritis, systemic lupus erythematosus, chronic obstructive pulmonary disease or the like.
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公开(公告)号:US20160002169A1
公开(公告)日:2016-01-07
申请号:US14755439
申请日:2015-06-30
Applicant: Takeda Pharmaceutical Company Limited
Inventor: Satoshi YAMAMOTO , Junya SHIRAI , Tsuneo ODA , Mitsunori KONO , Atsuko OCHIDA , Takashi IMADA , Hidekazu TOKUHARA , Yoshihide TOMATA , Naoki ISHII , Michiko TAWADA , Yoshiyuki FUKASE , Tomoya YUKAWA , Shoji FUKUMOTO
IPC: C07D217/26 , C07D491/056 , C07D491/048 , C07F7/08 , C07D471/04
CPC classification number: C07D217/26 , A61K31/4375 , A61K31/472 , A61K31/4741 , C07D217/14 , C07D471/04 , C07D491/048 , C07D491/056 , C07D491/14 , C07F7/0812
Abstract: The present invention provides a heterocyclic compound having a RORγt inhibitory action.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification. or a salt thereof.
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