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    THIENOPYRIMIDINE COMPOUNDS AND USE THEREOF
    2.
    发明申请
    THIENOPYRIMIDINE COMPOUNDS AND USE THEREOF 有权
    噻吗啉化合物及其用途

    公开(公告)号：US20140221381A1

    公开(公告)日：2014-08-07

    申请号：US14251119

    申请日：2014-04-11

    Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

    Inventor： Nobuo CHO ,  Takashi IMADA ,  Takenori HITAKA ,  Kazuhiro MIWA ,  Masami KUSAKA ,  Nobuhiro SUZUKI

    IPC: C07D495/04

    CPC classification number: C07D495/04 ,  A61K31/519

    Abstract: The present invention provides a compound represented by the formula: wherein R1 is a C1-4 alkyl; R2 is (1) a 5- to 7-membered nitrogen-containing heterocyclic group which may have a substituent selected from the group consisting of (1′) a halogen, (2′) a hydroxy group, (3′) a C1-4 alkyl and (4′) a C1-4 alkoxy, (2) a phenyl which may have a substituent selected from the group consisting of (1′) a halogen, (2′) a C1-4 alkoxy-C1-4 alkyl, (3′) a mono-C1-4 alkyl-carbamoyl-C1-4 alkyl, (4′) a C1-4 alkoxy and (5′) a mono-C1-4 alkylcarbamoyl-C1-4 alkoxy, or the like; R3 is a C1-4 alkyl; R4 is a C1-4 alkoxy, or the like; n is an integer of 1 to 4; or a salt thereof, as a thienopyrimidine compound having gonadotropin-releasing hormone antagonistic activity.

    Abstract translation: 本发明提供由下式表示的化合物：其中R1是C1-4烷基; R2是（1）可以具有选自（1'）卤素，（2'）羟基，（3'），C 1〜C 6的取代基的5〜7元含氮杂环基， 4烷基和（4'）C 1-4烷氧基，（2）可具有选自（1'）卤素，（2'）C 1-4烷氧基-C 1-4烷基的取代基的苯基 ，（3'）单-C 1-4烷基 - 氨基甲酰基-C 1-4烷基，（4'）C 1-4烷氧基和（5'）单-C 1-4烷基氨基甲酰基-C 1-4烷氧基等 ; R3是C1-4烷基; R4是C1-4烷氧基等; n为1〜4的整数， 或其盐作为具有促性腺激素释放激素拮抗活性的噻吩并嘧啶化合物。

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