公开(公告)号：US20160311811A1

公开(公告)日：2016-10-27

申请号：US15137161

申请日：2016-04-25

申请人： Takeda Pharmaceutical Company Limited

发明人： Masato YOSHIDA ,  Kazuaki TAKAMI ,  Yusuke TOMINARI ,  Zenyu SHIOKAWA ,  Akito SHIBUYA ,  Yusuke SASAKI ,  Tony GIBSON ,  Terufumi TAKAGI

IPC分类号： C07D413/14 ,  C07D401/14 ,  C07D403/14 ,  C07D403/04 ,  C07D495/04 ,  C07D487/04 ,  C07D487/10 ,  C07D491/107 ,  C07D409/14 ,  C07D471/10 ,  C07D417/14 ,  C07D471/04

CPC分类号： C07D413/14 ,  A61K9/06 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/4858 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D487/10 ,  C07D491/107 ,  C07D495/04

摘要： The present invention provides a heterocyclic compound having an IRAK-4 inhibitory action, which is useful for the prophylaxis or treatment of inflammatory disease, autoimmune disease, osteoarticular degenerative disease, neoplastic disease and the like, and a medicament containing thereof. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

摘要翻译： 其中每个符号如说明书中所定义，或其盐。

公开(公告)号：US20190359587A1

公开(公告)日：2019-11-28

申请号：US16332993

申请日：2017-09-14

申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED

发明人： Takaharu HIRAYAMA ,  Yasuhiro HIRATA ,  Yusuke TOMINARI ,  Naoki IWAMURA ,  Yusuke SASAKI ,  Moriteru ASANO ,  Terufumi TAKAGI ,  Masanori OKANIWA ,  Masato YOSHIDA ,  Shinichi IMAMURA

IPC分类号： C07D401/04 ,  A61P35/00 ,  C07D409/14 ,  C07D401/14 ,  C07D417/14 ,  C07D407/14

摘要： Provided is a heterocyclic amide compound that may have a PRS inhibitory action and is expected to be useful as a prophylactic or therapeutic agent for PRS associated diseases and the like including cancer. A compound represented by the following formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof.

公开(公告)号：US20190241566A1

公开(公告)日：2019-08-08

申请号：US16333296

申请日：2017-09-14

申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED

发明人： Takaharu HIRAYAMA ,  Yasuhiro HIRATA ,  Yusuke TOMINARI ,  Naoki IWAMURA ,  Yusuke SASAKI ,  Moriteru ASANO ,  Terufumi TAKAGI ,  Masanori OKANIWA ,  Masato YOSHIDA ,  Takashi ICHIKAWA ,  Shinichi IMAMURA

IPC分类号： C07D473/28 ,  C07D473/40 ,  C07D519/00 ,  C07D471/04 ,  C07D417/14 ,  C07D413/14 ,  C07D401/14 ,  C07D409/14 ,  C07D405/14 ,  C07D401/04 ,  A61P35/00

摘要： Provided is a heterocyclic amide compound that may have a PRS inhibitory action and is expected to be useful as a prophylactic or therapeutic agent for PRS associated diseases and the like including cancer. A compound represented by the following formula (I): wherein a group represented by is a group represented by the following formula (II) or the following formula (III): and other symbols are as described in the DESCRIPTION, or a salt thereof.

公开(公告)号：US20190169166A1

公开(公告)日：2019-06-06

申请号：US16323863

申请日：2017-08-09

申请人： Takeda Pharmaceutical Company Limited

发明人： Jun FUJIMOTO ,  Xin LIU ,  Osamu KURASAWA ,  Terufumi TAKAGI ,  Douglas Robert CARY ,  Hiroshi BANNO ,  Yasutomi ASANO ,  Takuto KOJIMA

IPC分类号： C07D401/12 ,  C07D239/42 ,  A61P35/00

摘要： Provided is a heterocyclic compound that may have a GCN2 inhibitory action, and is expected to be useful for the prophylaxis or treatment of GCN2 associated diseases including cancer and the like. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof.

公开(公告)号：US20150133451A1

公开(公告)日：2015-05-14

申请号：US14533326

申请日：2014-11-05

申请人： Takeda Pharmaceutical Company Limited

发明人： Masato Yoshida ,  Kazuaki TAKAMI ,  Yusuke TOMINARI ,  Zenyu SHIOKAWA ,  Akito SHIBUYA ,  Yusuke SASAKI ,  Tony GIBSON ,  Terufumi TAKAGI

IPC分类号： C07D413/14 ,  C07D401/14 ,  C07D405/14 ,  C07D417/14

CPC分类号： C07D413/14 ,  A61K9/06 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/4858 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D487/10 ,  C07D491/107 ,  C07D495/04

摘要： The present invention provides a heterocyclic compound having an IRAK-4 inhibitory action, which is useful for the prophylaxis or treatment of inflammatory disease, autoimmune disease, osteoarticular degenerative disease, neoplastic disease and the like, and a medicament containing thereof. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

摘要翻译： 本发明提供具有IRAK-4抑制作用的杂环化合物，其可用于预防或治疗炎性疾病，自身免疫性疾病，骨关节炎性退行性疾病，肿瘤性疾病等，以及含有它们的药物。 本发明涉及由式（I）表示的化合物：其中每个符号如说明书中所定义，或其盐。