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公开(公告)号：US20230117295A1
公开(公告)日：2023-04-20
申请号：US18075853
申请日：2022-12-06
发明人： Koji ONO , Masahiro ITO , Toshio TANAKA , Moriteru ASANO , Takaharu HIRAYAMA , Jun FUJIMOTO , Nobuki SAKAUCHI , Yasuhiro HIRATA , Akinori TOITA , Nao MORISHITA , Hironori KOKUBO , Yasuhiro IMAEDA , Hironobu MAEZAKI , Douglas Robert CARY , Ryo MIZOJIRI , Nobuo CHO , Hiroshi BANNO , Hidekazu TOKUHARA , Yasuyoshi ARIKAWA
IPC分类号： C07D401/14 , C07D403/14 , C07D401/12 , C07D471/10 , C07D495/10 , C07D405/12 , C07D403/12 , C07D213/84 , C07D487/10 , C07D405/14 , A61P35/00
摘要： Provided is a compound that may have a superior CDK12 inhibitory action and is expected to be useful as a prophylactic or therapeutic drug for cancer and the like. A compound represented by the following formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof.
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公开(公告)号：US20210363130A1
公开(公告)日：2021-11-25
申请号：US17042394
申请日：2019-03-28
发明人： Koji ONO , Masahiro ITO , Toshio TANAKA , Moriteru ASANO , Takaharu HIRAYAMA , Jun FUJIMOTO , Nobuki SAKAUCHI , Yasuhiro HIRATA , Akinori TOITA , Nao MORISHITA , Hironori KOKUBO , Yasuhiro IMAEDA , Hironobu MAEZAKI , Douglas Robert CARY , Ryo MIZOJIRI , Nobuo CHO , Hiroshi BANNO , Hidekazu TOKUHARA , Yasuyoshi ARIKAWA
IPC分类号： C07D401/14 , A61P35/00 , C07D401/12 , C07D405/14 , C07D405/12 , C07D213/84 , C07D403/14 , C07D403/12 , C07D471/10 , C07D487/10 , C07D495/10
摘要： Provided is a compound that may have a superior CDK12 inhibitory action and is expected to be useful as a prophylactic or therapeutic drug for cancer and the like. A compound represented by the following formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof.
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公开(公告)号：US20180079723A1
公开(公告)日：2018-03-22
申请号：US15563128
申请日：2016-03-30
发明人： Ryo Mizojiri , Moriteru ASANO , Daisuke TOMITA , Hiroshi BANNO , Michiko TAWADA , Noriyuki NII , Krista E. GIPSON , Hironobu MAEZAKI , Shuntaro TSUCHIYA , Mayumi IMAI , Yuichiro AMANO
IPC分类号： C07D213/65 , C07C233/25 , C07D401/12 , C07C255/54 , C07D213/69 , C07C233/18 , C07D263/42 , C07D263/32 , C07D413/04 , C07D239/34 , C07D241/18 , C07D277/34 , C07D231/12 , C07D207/12 , C07D261/08 , C07D417/04 , C07D237/14 , C07D211/46 , C07D213/74 , C07D213/81
CPC分类号： C07D213/65 , A61K31/165 , A61K31/167 , A61K31/277 , A61K31/381 , A61K31/402 , A61K31/415 , A61K31/42 , A61K31/421 , A61K31/426 , A61K31/427 , A61K31/44 , A61K31/4412 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/451 , A61K31/454 , A61K31/4965 , A61K31/50 , A61K31/501 , A61K31/505 , A61K31/506 , C07C233/18 , C07C233/25 , C07C233/47 , C07C255/54 , C07C2601/02 , C07C2601/14 , C07D207/08 , C07D207/12 , C07D211/44 , C07D211/46 , C07D213/643 , C07D213/69 , C07D213/74 , C07D213/75 , C07D213/81 , C07D231/12 , C07D237/14 , C07D239/34 , C07D241/18 , C07D261/08 , C07D263/32 , C07D263/42 , C07D277/34 , C07D333/20 , C07D401/04 , C07D401/12 , C07D409/04 , C07D413/04 , C07D417/04 , C12N9/99 , C12N15/09
摘要： The present invention relates to a compound which may be useful as an agent for the prophylaxis or treatment of cancer, hepatitis, hepatic fibrosis, fatty liver and the like.
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公开(公告)号：US20190359587A1
公开(公告)日：2019-11-28
申请号：US16332993
申请日：2017-09-14
发明人： Takaharu HIRAYAMA , Yasuhiro HIRATA , Yusuke TOMINARI , Naoki IWAMURA , Yusuke SASAKI , Moriteru ASANO , Terufumi TAKAGI , Masanori OKANIWA , Masato YOSHIDA , Shinichi IMAMURA
IPC分类号： C07D401/04 , A61P35/00 , C07D409/14 , C07D401/14 , C07D417/14 , C07D407/14
摘要： Provided is a heterocyclic amide compound that may have a PRS inhibitory action and is expected to be useful as a prophylactic or therapeutic agent for PRS associated diseases and the like including cancer. A compound represented by the following formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof.
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公开(公告)号：US20190241566A1
公开(公告)日：2019-08-08
申请号：US16333296
申请日：2017-09-14
发明人： Takaharu HIRAYAMA , Yasuhiro HIRATA , Yusuke TOMINARI , Naoki IWAMURA , Yusuke SASAKI , Moriteru ASANO , Terufumi TAKAGI , Masanori OKANIWA , Masato YOSHIDA , Takashi ICHIKAWA , Shinichi IMAMURA
IPC分类号： C07D473/28 , C07D473/40 , C07D519/00 , C07D471/04 , C07D417/14 , C07D413/14 , C07D401/14 , C07D409/14 , C07D405/14 , C07D401/04 , A61P35/00
摘要： Provided is a heterocyclic amide compound that may have a PRS inhibitory action and is expected to be useful as a prophylactic or therapeutic agent for PRS associated diseases and the like including cancer. A compound represented by the following formula (I): wherein a group represented by is a group represented by the following formula (II) or the following formula (III): and other symbols are as described in the DESCRIPTION, or a salt thereof.
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公开(公告)号：US20180002322A1
公开(公告)日：2018-01-04
申请号：US15529816
申请日：2015-11-25
发明人： Ryo Mizojiri , Hiroshi BANNO , Moriteru ASANO , Daisuke TOMITA , Noriyuki Nii , Hironobu MAEZAKI , Michiko TAWADA
IPC分类号： C07D413/04 , C07D471/04 , C07D417/04 , C07D413/14 , C07D405/04 , C07D231/56 , C07D401/04 , C07D333/56 , C07D307/81 , C07D263/57 , C07D498/04 , C07D413/12
CPC分类号： C07D413/04 , A61K31/343 , A61K31/381 , A61K31/416 , A61K31/423 , A61K31/428 , A61K31/437 , A61K31/443 , A61K31/4439 , A61K31/497 , A61K31/501 , A61K31/517 , A61K31/5377 , C07D231/56 , C07D263/54 , C07D263/57 , C07D307/81 , C07D333/56 , C07D401/04 , C07D403/04 , C07D405/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D471/04 , C07D498/04 , C12N15/09
摘要： Provided is a bicyclic compound having an acetyl-CoA carboxylase inhibitory action. A compound represented by the formula: wherein each symbol is as described in the DESCRIPTION, or a salt thereof has an acetyl-CoA carboxylase inhibitory action, is useful for the prophylaxis or treatment of cancer, inflammatory diseases and the like, and has superior efficacy.
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