公开(公告)号：US10696651B2

公开(公告)日：2020-06-30

申请号：US16323863

申请日：2017-08-09

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Jun Fujimoto ,  Xin Liu ,  Osamu Kurasawa ,  Terufumi Takagi ,  Douglas Robert Cary ,  Hiroshi Banno ,  Yasutomi Asano ,  Takuto Kojima

IPC: C07D401/12 ,  C07D403/12 ,  C07D401/14 ,  C07D213/75 ,  C07D405/12 ,  C07D239/42 ,  C07D241/12 ,  C07D471/04 ,  C07D498/04 ,  C07D213/65 ,  A61P35/00 ,  C07D241/20 ,  C07D213/73 ,  A61K31/53 ,  A61K31/505 ,  A61K31/4406 ,  A61K31/444 ,  A61K31/4965 ,  C07D213/68 ,  C07D213/42 ,  A61K31/506 ,  A61K31/497 ,  A61K31/4375 ,  C07D239/20 ,  A61P43/00 ,  A61K31/5383 ,  A61K31/437 ,  A61K31/44 ,  C07D253/06 ,  C07D231/12 ,  C07D239/30 ,  C07D239/34 ,  C07D239/48 ,  C07D253/07 ,  C07D409/12 ,  C07D487/04

Abstract: Provided is a heterocyclic compound that may have a GCN2 inhibitory action, and is expected to be useful for the prophylaxis or treatment of GCN2 associated diseases including cancer and the like. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof.

公开(公告)号：US11407748B2

公开(公告)日：2022-08-09

申请号：US16753613

申请日：2018-10-04

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Shinji Nakamura ,  Satoshi Mikami ,  Tomoaki Hasui ,  Tohru Yamashita ,  Shinji Morimoto ,  Hidekazu Tokuhara ,  Norio Oyabu ,  Masami Yamada ,  Atsuko Ochida ,  Kazuaki Takami ,  Xin Liu

IPC: A61K31/519 ,  C07D471/04 ,  C07D487/04 ,  A61K9/20 ,  C07D519/00

Abstract: The present invention aims to provide a heterocyclic compound having an AMPA receptor potentiator effect, which is expected to be useful as an agent for the prophylaxis or treatment of depression, Alzheimer's disease, schizophrenia, attention deficit hyperactivity disorder (ADHD) and the like.
The present invention relates to a compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof.

公开(公告)号：US10981934B2

公开(公告)日：2021-04-20

申请号：US16663601

申请日：2019-10-25

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Youichi Kawakita ,  Takuto Kojima ,  Noriyuki Nii ,  Yoshiteru Ito ,  Nobuki Sakauchi ,  Hiroshi Banno ,  Xin Liu ,  Koji Ono ,  Keisuke Imamura ,  Shinichi Imamura

IPC: A61K31/53 ,  C07D519/00 ,  A61K31/444 ,  A61K31/5025 ,  A61K31/519 ,  A61K31/4985 ,  A61P35/00

Abstract: Provided is a compound represented by the following formula, or a salt thereof: [wherein each symbol is as defined herein.].

公开(公告)号：US10577382B2

公开(公告)日：2020-03-03

申请号：US16094030

申请日：2017-04-27

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Youichi Kawakita ,  Takuto Kojima ,  Noriyuki Nii ,  Yoshiteru Ito ,  Nobuki Sakauchi ,  Hiroshi Banno ,  Xin Liu ,  Koji Ono ,  Keisuke Imamura ,  Shinichi Imamura

IPC: C07D519/00 ,  A61K31/53 ,  A61P35/00

Abstract: Provided is a compound represented by the following formula, or a salt thereof: [wherein each symbol is as defined herein].