公开(公告)号：US10301292B2

公开(公告)日：2019-05-28

申请号：US15529816

申请日：2015-11-25

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Ryo Mizojiri ,  Hiroshi Banno ,  Moriteru Asano ,  Daisuke Tomita ,  Noriyuki Nii ,  Hironobu Maezaki ,  Michiko Tawada

IPC: C07D413/04 ,  C07D413/14 ,  A61K31/343 ,  A61K31/381 ,  A61K31/416 ,  A61K31/423 ,  A61K31/428 ,  A61K31/437 ,  A61K31/443 ,  A61K31/4439 ,  A61K31/497 ,  A61K31/501 ,  A61K31/517 ,  A61K31/5377 ,  C07D231/56 ,  C07D333/56 ,  C07D401/04 ,  C07D403/04 ,  C07D405/04 ,  C07D413/12 ,  C07D417/04 ,  C07D471/04 ,  C07D263/54 ,  C07D498/04 ,  C07D307/81 ,  C07D263/57 ,  C12N15/09

Abstract: Provided is a bicyclic compound having an acetyl-CoA carboxylase inhibitory action. A compound represented by the formula: wherein each symbol is as described in the DESCRIPTION, or a salt thereof has an acetyl-CoA carboxylase inhibitory action, is useful for the prophylaxis or treatment of cancer, inflammatory diseases and the like, and has superior efficacy.

公开(公告)号：US11230545B2

公开(公告)日：2022-01-25

申请号：US17367171

申请日：2021-07-02

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Takaharu Hirayama ,  Yoshiteru Ito ,  Hiroshi Banno ,  Hidekazu Tokuhara ,  Toshio Tanaka ,  Yasuyoshi Arikawa ,  Noriyuki Nii ,  Youichi Kawakita ,  Shinichi Imamura

IPC: C07D471/04

Abstract: Provided is a compound that can have an effect of inhibiting MALT1 and is expected as useful as a prophylactic or therapeutic drug for cancer, etc. A compound represented by formula (I) [wherein each symbol is as defined in the description], a salt thereof, or a cocrystal, a hydrate or a solvate of the same.

公开(公告)号：US20220089595A1

公开(公告)日：2022-03-24

申请号：US17528677

申请日：2021-11-17

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Takaharu Hirayama ,  Yoshiteru Ito ,  Noriyuki Nii ,  Youichi Kawakita ,  Shinichi Imamura

IPC: C07D471/04

Abstract: Provided is a compound that can have an effect of inhibiting MALT1 and is expected as useful as a prophylactic or therapeutic drug for cancer, etc. A compound represented by formula (I) [wherein each symbol is as defined in the description], a salt thereof, or a cocrystal, a hydrate or a solvate of the same.

公开(公告)号：US10981934B2

公开(公告)日：2021-04-20

申请号：US16663601

申请日：2019-10-25

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Youichi Kawakita ,  Takuto Kojima ,  Noriyuki Nii ,  Yoshiteru Ito ,  Nobuki Sakauchi ,  Hiroshi Banno ,  Xin Liu ,  Koji Ono ,  Keisuke Imamura ,  Shinichi Imamura

IPC: A61K31/53 ,  C07D519/00 ,  A61K31/444 ,  A61K31/5025 ,  A61K31/519 ,  A61K31/4985 ,  A61P35/00

Abstract: Provided is a compound represented by the following formula, or a salt thereof: [wherein each symbol is as defined herein.].

公开(公告)号：US10577382B2

公开(公告)日：2020-03-03

申请号：US16094030

申请日：2017-04-27

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Youichi Kawakita ,  Takuto Kojima ,  Noriyuki Nii ,  Yoshiteru Ito ,  Nobuki Sakauchi ,  Hiroshi Banno ,  Xin Liu ,  Koji Ono ,  Keisuke Imamura ,  Shinichi Imamura

IPC: C07D519/00 ,  A61K31/53 ,  A61P35/00

Abstract: Provided is a compound represented by the following formula, or a salt thereof: [wherein each symbol is as defined herein].

公开(公告)号：US10252997B2

公开(公告)日：2019-04-09

申请号：US15563128

申请日：2016-03-30

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Ryo Mizojiri ,  Moriteru Asano ,  Daisuke Tomita ,  Hiroshi Banno ,  Michiko Tawada ,  Noriyuki Nii ,  Krista E. Gipson ,  Hironobu Maezaki ,  Shuntarou Tsuchiya ,  Mayumi Imai ,  Yuichiro Amano

IPC: C07D213/65 ,  A61K31/165 ,  A61K31/167 ,  A61K31/277 ,  A61K31/381 ,  A61K31/402 ,  A61K31/415 ,  A61K31/42 ,  A61K31/421 ,  A61K31/426 ,  A61K31/427 ,  A61K31/44 ,  A61K31/4412 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/451 ,  A61K31/454 ,  A61K31/4965 ,  A61K31/50 ,  A61K31/501 ,  A61K31/505 ,  A61K31/506 ,  C07D213/75 ,  C07D213/81 ,  C07D231/12 ,  C07D333/20 ,  C07D401/04 ,  C07D237/14 ,  C07D239/34 ,  C07D409/04 ,  C07D413/04 ,  C07D241/18 ,  C07D417/04 ,  C07C233/18 ,  C07C233/47 ,  C07D261/08 ,  C07D263/32 ,  C07D263/42 ,  C07D207/08 ,  C07D207/12 ,  C07D277/34 ,  C07D211/44 ,  C07D213/643 ,  C07D213/69 ,  C07C233/25 ,  C07C255/54 ,  C07D211/46 ,  C07D213/74 ,  C07D401/12 ,  C12N9/99 ,  C12N15/09

Abstract: The present invention relates to a compound which may be useful as an agent for the prophylaxis or treatment of cancer, hepatitis, hepatic fibrosis, fatty liver and the like.

公开(公告)号：US12152027B2

公开(公告)日：2024-11-26

申请号：US17296434

申请日：2019-11-27

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Takaharu Hirayama ,  Yoshiteru Ito ,  Noriyuki Nii ,  Youichi Kawakita ,  Shinichi Imamura

IPC: C07D487/04 ,  C07D471/04

Abstract: Provided is a compound that can have an effect of inhibiting MALT1 and is expected as useful as a prophylactic or therapeutic drug for cancer, etc. A compound represented by formula (I) [wherein each symbol is as defined in the description], a salt thereof, or a cocrystal, a hydrate or a solvate of the same.

公开(公告)号：US11897879B2

公开(公告)日：2024-02-13

申请号：US17528677

申请日：2021-11-17

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Takaharu Hirayama ,  Yoshiteru Ito ,  Noriyuki Nii ,  Youichi Kawakita ,  Shinichi Imamura

IPC: C07D471/04 ,  C07D487/04

CPC classification number: C07D471/04 ,  C07D487/04

Abstract: Provided is a compound that can have an effect of inhibiting MALT1 and is expected as useful as a prophylactic or therapeutic drug for cancer, etc. A compound represented by formula (I) [wherein each symbol is as defined in the description], a salt thereof, or a cocrystal, a hydrate or a solvate of the same.

公开(公告)号：US20210332045A1

公开(公告)日：2021-10-28

申请号：US17367171

申请日：2021-07-02

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Takaharu Hirayama ,  Yoshiteru Ito ,  Hiroshi Banno ,  Hidekazu Tokuhara ,  Toshio Tanaka ,  Yasuyoshi Arikawa ,  Noriyuki Nii ,  Youichi Kawakita ,  Shinichi Imamura

IPC: C07D471/04

Abstract: Provided is a compound that can have an effect of inhibiting MALT1 and is expected as useful as a prophylactic or therapeutic drug for cancer, etc. A compound represented by formula (I) [wherein each symbol is as defined in the description], a salt thereof, or a cocrystal, a hydrate or a solvate of the same.

公开(公告)号：US20180002322A1

公开(公告)日：2018-01-04

申请号：US15529816

申请日：2015-11-25

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Ryo Mizojiri ,  Hiroshi BANNO ,  Moriteru ASANO ,  Daisuke TOMITA ,  Noriyuki Nii ,  Hironobu MAEZAKI ,  Michiko TAWADA

IPC: C07D413/04 ,  C07D471/04 ,  C07D417/04 ,  C07D413/14 ,  C07D405/04 ,  C07D231/56 ,  C07D401/04 ,  C07D333/56 ,  C07D307/81 ,  C07D263/57 ,  C07D498/04 ,  C07D413/12

CPC classification number: C07D413/04 ,  A61K31/343 ,  A61K31/381 ,  A61K31/416 ,  A61K31/423 ,  A61K31/428 ,  A61K31/437 ,  A61K31/443 ,  A61K31/4439 ,  A61K31/497 ,  A61K31/501 ,  A61K31/517 ,  A61K31/5377 ,  C07D231/56 ,  C07D263/54 ,  C07D263/57 ,  C07D307/81 ,  C07D333/56 ,  C07D401/04 ,  C07D403/04 ,  C07D405/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D471/04 ,  C07D498/04 ,  C12N15/09

Abstract: Provided is a bicyclic compound having an acetyl-CoA carboxylase inhibitory action. A compound represented by the formula: wherein each symbol is as described in the DESCRIPTION, or a salt thereof has an acetyl-CoA carboxylase inhibitory action, is useful for the prophylaxis or treatment of cancer, inflammatory diseases and the like, and has superior efficacy.