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    DRUG DELIVERY DEVICES AND METHODS FOR DRUG DELIVERY
    1.
    发明申请
    DRUG DELIVERY DEVICES AND METHODS FOR DRUG DELIVERY 有权
    药物递送装置和用于药物递送的方法

    公开(公告)号：US20160008271A1

    公开(公告)日：2016-01-14

    申请号：US14770494

    申请日：2014-03-14

    申请人： TARIS BIOMEDICAL LLC

    发明人： Heejin LEE

    IPC分类号： A61K9/00 ,  A61M31/00 ,  A61K31/167

    CPC分类号： A61K9/0004 ,  A61K9/0034 ,  A61K31/167 ,  A61M31/00

    摘要： An orifice-free drug delivery device is provided. In an embodiment, the device includes a body having at least one water-permeable wall bounding a reservoir defined within the body. A drug formulation is disposed within the reservoir. The body has an elastic portion and at least one restraining plug closing off an opening of the body. The opening is in fluid communication with the reservoir, and the restraining plug contacts the elastic portion of the body and controls release of the drug from the device by the transient formation of one or more microchannels between the elastic portion of the body and the at least one restraining plug. The elastic portion may define an opening having an inner diameter, which is exceeded by the outer diameter of the restraining plug by at least 3%.

    摘要翻译： 提供无孔口的药物输送装置。 在一个实施例中，该装置包括具有限定在体内限定的储存器的至少一个水可渗透壁的主体。 药物制剂设置在储存器内。 主体具有弹性部分和至少一个限制塞，其封闭主体的开口。 开口与储存器流体连通，并且约束塞接触身体的弹性部分，并且通过在身体的弹性部分和至少在身体的弹性部分之间的一个或多个微通道的瞬时形成来控制药物从装置的释放 一个限制插头 弹性部分可以限定具有内径的开口，该内径超过限制塞的外径至少3％。

    URODYNAMIC ASSESSMENT SYSTEMS AND METHODS
    2.
    发明申请
    URODYNAMIC ASSESSMENT SYSTEMS AND METHODS 有权

    公开(公告)号：US20210196124A1

    公开(公告)日：2021-07-01

    申请号：US17203976

    申请日：2021-03-17

    申请人： TARIS Biomedical LLC

    发明人： Joseph KALT ,  Dennis GIESING ,  Heejin LEE ,  Michael J. Cima

    IPC分类号： A61B5/00 ,  A61B5/07 ,  A61B5/20 ,  A61B5/03

    摘要： Urodynamic assessment systems, intravesical devices, and methods of their use are provided. In one embodiment, an intravesical device includes an elastic body including an elongated tube defining a reservoir lumen, and a sensor disposed at least partially in the reservoir lumen and configured to measure or detect one or more parameters. The intravesical device is deformable between a deployment shape for passage of the intravesical device through the urethra into the bladder and a retention shape for preventing voiding of the intravesical device through the urethra.

    DRUG DELIVERY DEVICES AND METHODS
    3.
    发明申请
    DRUG DELIVERY DEVICES AND METHODS 有权

    公开(公告)号：US20210146013A1

    公开(公告)日：2021-05-20

    申请号：US17158322

    申请日：2021-01-26

    申请人： TARIS Biomedical LLC

    发明人： Heejin LEE ,  Karen DANIEL ,  Cheryl LARRIVEE-ELKINS ,  Vikas AGARWAL ,  Hong Linh HO DUC

    IPC分类号： A61L29/06 ,  A61M31/00 ,  A61K9/00 ,  A61K9/14 ,  A61K9/20 ,  A61K31/167 ,  A61L29/14 ,  A61L29/16

    摘要： Drug delivery devices are provided in which much of a drug payload within the device remains within an area proximal to a wall of the device through which the drug must pass for release of the drug from the device into a patient. In one case, the device may include a drug reservoir portion which has a drug reservoir lumen bounded by a reservoir wall having an inner surface; a drug located in the drug reservoir lumen; and a core region which does not comprise the drug, wherein the drug is disposed between the inner surface of the reservoir wall and the core region. The device may be elastically deformable between a first shape suited for insertion through a lumen into a body cavity of the patient and a second shape suited to retain the device within the body cavity.

    INTRAVESICAL DRUG DELIVERY DEVICES AND METHODS INCLUDING ELASTIC POLYMER-DRUG MATRIX SYSTEMS
    5.
    发明申请
    INTRAVESICAL DRUG DELIVERY DEVICES AND METHODS INCLUDING ELASTIC POLYMER-DRUG MATRIX SYSTEMS 审中-公开

    公开(公告)号：US20170165460A1

    公开(公告)日：2017-06-15

    申请号：US15321110

    申请日：2015-06-26

    申请人： TARIS Biomedical LLC

    发明人： Heejin LEE ,  Karen DANIEL

    IPC分类号： A61M31/00 ,  A61K9/00

    摘要： Intravesical drug delivery devices are provided which may include an elongated body formed of a matrix system of a drug dispersed in a silicone, wherein the elongated body has a first end, an opposed second end, and an intermediate portion between the first and second ends, and wherein the silicone of the matrix system is cured to bias the elongated body in a coiled retention shape, such that the device is elastically deformable between a relatively straightened shape suited for insertion of the device through a urethra and into the urinary bladder of a patient and the coiled retention shape which is suited to retain the device within the urinary bladder.

    DRUG DELIVERY DEVICES AND METHODS FOR CONTROLLED DRUG RELEASE THROUGH DEVICE ORIFICE
    6.
    发明申请
    DRUG DELIVERY DEVICES AND METHODS FOR CONTROLLED DRUG RELEASE THROUGH DEVICE ORIFICE 审中-公开
    药物递送装置和方法通过装置配制来控制药物释放

    公开(公告)号：US20150360012A1

    公开(公告)日：2015-12-17

    申请号：US14768291

    申请日：2014-03-05

    申请人： TARIS BIOMEDICAL, LLC

    发明人： Matthew SANSONE ,  Karen DANIEL ,  Grace KIM ,  Heejin LEE

    IPC分类号： A61M31/00

    CPC分类号： A61M31/002 ,  A61K9/0024 ,  A61M31/00 ,  A61M31/007 ,  A61M37/0069 ,  A61M2205/0216 ,  A61M2205/04 ,  A61M2210/1085 ,  A61M2210/1089

    摘要： A drug delivery device is provided. In an embodiment, the device includes a device body having an elongated drug reservoir lumen, a drug positioned in the drug reservoir lumen, and at least one end plug positioned at an end of the device body, for example inserted in an end of the drug reservoir lumen. The end plug may include an aperture therethough, and the drug delivery device may be configured to release the drug from the drug reservoir lumen through the aperture.

    摘要翻译： 提供药物输送装置。 在一个实施例中，该装置包括具有细长的药物储存器腔，设置在药物储存器腔中的药物和位于装置主体的端部处的至少一个端塞的装置主体，例如插入药物的末端 储层流明。 端塞可以包括孔，并且药物递送装置可以被配置为通过孔从药物储存器腔释放药物。

    MULTI-UNIT DRUG DELIVERY DEVICES AND METHODS
    9.
    发明申请
    MULTI-UNIT DRUG DELIVERY DEVICES AND METHODS 审中-公开
    多单位药物递送装置和方法

    公开(公告)号：US20160199544A1

    公开(公告)日：2016-07-14

    申请号：US14913185

    申请日：2014-08-19

    申请人： TARIS BIOMEDICAL LLC

    发明人： Heejin LEE ,  Karen DANIEL ,  Matthew SANSONE

    IPC分类号： A61L31/16 ,  A61L31/04 ,  A61L31/08 ,  A61K31/7068 ,  A61K47/18

    摘要： Abstract of the Disclosure Implantable drug delivery devices include a housing defining a reservoir, a first unit within the reservoir, and a second unit within the reservoir. The first unit contains a drug and the second unit contains a functional agent that facilitates release of the drug. Intravesical drug delivery devices include a housing portion containing a drug formulation and a housing portion containing an excipient, and are configured to release the drug according to a first release profile and the excipient according to a second release profile. Methods include inserting any of these devices into a patient and releasing drug from the device.

    摘要翻译： 公开的可植入药物递送装置包括限定储存器的壳体，储存器内的第一单元和储存器内的第二单元。 第一单元含有药物，第二单元含有促进药物释放的功能剂。 膀胱内药物递送装置包括含有药物制剂的壳体部分和含有赋形剂的壳体部分，并且被配置为根据第一释放特征和根据第二释放特征的赋形剂释放药物。 方法包括将任何这些装置插入患者体内并从装置中释放药物。