公开(公告)号：US20160266038A1

公开(公告)日：2016-09-15

申请号：US14442160

申请日：2013-08-23

申请人： Technical Institute of Physics and Chemistry of the Chinese Academy of Sciences

发明人： Pengfei Wang ,  Minhuan Lan ,  Hongyan Zhang

IPC分类号： G01N21/552 ,  G01N33/487

CPC分类号： G01N21/553 ,  C03C17/09 ,  C03C17/38 ,  C03C2217/255 ,  C03C2218/151 ,  C03C2218/156 ,  C23C14/18 ,  G01N33/487

摘要： Disclosed is a surface plasmon resonance sensor chip, comprising a glass substrate layer, a gold film layer and a probe molecule layer. The gold film layer is disposed on the glass substrate layer and the probe molecule layer is disposed on the gold film layer. Also disclosed is a method for preparing the surface plasmon resonance sensor chip. By means of a surface plasmon resonance spectrum generated by the surface of the gold film disposed on the glass substrate, the content of lipopolysaccharide in an aqueous solution is detected in a fast, simple, quantitative and ultra-sensitive way.

摘要翻译： 公开了一种表面等离子体共振传感器芯片，其包括玻璃基底层，金膜层和探针分子层。 金膜层设置在玻璃基板层上，探针分子层设置在金膜层上。 还公开了一种制备表面等离子体共振传感器芯片的方法。 通过由设置在玻璃基板上的金膜的表面产生的表面等离子体共振光谱，以快速，简单，定量和超灵敏的方式检测水溶液中的脂多糖的含量。

公开(公告)号：US11154548B2

公开(公告)日：2021-10-26

申请号：US15769789

申请日：2016-10-21

申请人： Technical Institute of Physics and Chemistry of the Chinese Academy of Sciences

发明人： Pengfei Wang ,  Jiasheng Wu ,  Weimin Liu ,  Ying Gu ,  Jiechao Ge ,  Xiuli Zheng ,  Hongyan Zhang

IPC分类号： C07C217/12 ,  C07C221/00 ,  C07C225/22 ,  C07C225/32 ,  C07C229/18 ,  C07C237/08 ,  C07C239/14 ,  C07C243/22 ,  C07C249/02 ,  C07C251/24 ,  C07C251/56 ,  C07C251/86 ,  C07C309/69 ,  A61K31/122 ,  A61K31/135 ,  A61K31/473 ,  A61K41/00 ,  A61K47/54 ,  A61K47/60 ,  A61P35/00 ,  C07C323/25 ,  C07C319/18 ,  C07D279/14 ,  C07D487/08 ,  C07D513/06 ,  C07D513/16 ,  C07D241/38 ,  C07C50/36 ,  C07D221/02

摘要： The invention discloses a monosubstituted or polysubstituted amphiphilic hypocrellin derivative, and a preparation method and application thereof. The amphiphilic hypocrellin derivative substituted by a group containing PEG, a quaternary ammonium salt or the like prepared according to the invention has an obvious red shift in its absorption spectrum and a significantly enhanced molar extinction coefficient, compared with the parent hypocrellin, can efficiently produce singlet state oxygen and other reactive oxygen species under photosensitive conditions; has different amphiphilicities and increased biocompatibility with cells or tissues by regulating its hydrophilicity and hydrophobicity; can meet the requirements of different clinical drugs, and solves the requirements of different drug delivery methods for different drug hydrophilicity and lipophilicity. Under identical conditions, the amphiphilic hypocrellin derivative photosensitizer according to the invention has higher ability to photodynamically inactivate tumor cells than the first and second generation commercial photosensitizers.

公开(公告)号：US11439707B2

公开(公告)日：2022-09-13

申请号：US16645301

申请日：2018-09-05

申请人： TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES

发明人： Pengfei Wang ,  Jiasheng Wu ,  Weimin Liu ,  Xiuli Zheng ,  Ying Gu

IPC分类号： A61K47/10 ,  A61K41/00 ,  C07C221/00 ,  C07C225/32 ,  C07C227/28 ,  C07C229/16 ,  C07C229/28 ,  C07C241/02 ,  C07C243/20 ,  C07C323/30 ,  C07C323/38 ,  C07D295/13 ,  C07D295/205 ,  C07D401/12 ,  C07D403/12 ,  C07D519/00

摘要： The present invention discloses a hypocrellin derivative substituted both in a pen-position and in a 2-position by an amino, and a preparation method and use thereof. A general structural formula of the derivative is as represented by formulas I-a to I-d: The hypocrellin derivative substituted both in a peri-position and in a 2-position by an amino prepared in the present invention has a maximum absorption wavelength of 600-650 nm and a molar extinction coefficient reaching about 20000-40000 M−1cm−1. Compared with unmodified hypocrellin or hypocrellin having only a 2-position modified, an absorption spectrum of the derivative is significantly red-shifted and the molar extinction coefficient is greatly improved, and the derivative can efficiently produce reactive oxygen species such as singlet oxygen in a photosensitive condition. In the same condition, the hypocrellin derivative substituted both in a pen-position and in a 2-position by an amino involved in the present invention, when used as a photosensitizer, has a stronger ability to photo-dynamically inactivate tumor cells than the first and second generation commercial photosensitizers.

公开(公告)号：US20180338965A1

公开(公告)日：2018-11-29

申请号：US15769789

申请日：2016-10-21

申请人： TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES

发明人： Pengfei Wang ,  Jiasheng Wu ,  Weimin Liu ,  Ying Gu ,  Jiechao Ge ,  Xiuli Zheng ,  Hongyan Zhang

IPC分类号： A61K31/473 ,  C07D221/02 ,  C07C225/32 ,  A61K31/122 ,  A61K31/135 ,  C07C50/36

摘要： The invention discloses a monosubstituted or polysubstituted amphiphilic hypocrellin derivative, and a preparation method and application thereof. The amphiphilic hypocrellin derivative substituted by a group containing PEG, a quaternary ammonium salt or the like prepared according to the invention has an obvious red shift in its absorption spectrum and a significantly enhanced molar extinction coefficient, compared with the parent hypocrellin, can efficiently produce singlet state oxygen and other reactive oxygen species under photosensitive conditions; has different amphiphilicities and increased biocompatibility with cells or tissues by regulating its hydrophilicity and hydrophobicity; can meet the requirements of different clinical drugs, and solves the requirements of different drug delivery methods for different drug hydrophilicity and lipophilicity. Under identical conditions, the amphiphilic hypocrellin derivative photosensitizer according to the invention has higher ability to photodynamically inactivate tumor cells than the first and second generation commercial photosensitizers.