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    Methods and Systems of Growing and Harvesting Cells in a Hollow Fiber Bioreactor System with Control Conditions
    1.
    发明申请
    Methods and Systems of Growing and Harvesting Cells in a Hollow Fiber Bioreactor System with Control Conditions 审中-公开
    在具有控制条件的中空纤维生物反应器系统中生长和收获细胞的方法和系统

    公开(公告)号：US20150079664A1

    公开(公告)日：2015-03-19

    申请号：US14548617

    申请日：2014-11-20

    申请人： Terumo BCT, Inc.

    发明人： Thomas G. DILORENZO ,  Edward Allan STANTON, IV ,  Glen Delbert ANTWILER ,  Michael E. KINZIE ,  Brian J. NANKERVIS ,  Monique GIVENS ,  Casey V. MEDINA ,  Jon A. DODD

    IPC分类号： C12M1/34 ,  C12M1/00 ,  C12M1/36

    CPC分类号： C12M41/44 ,  C12M23/42 ,  C12M23/44 ,  C12M25/10 ,  C12M25/12 ,  C12M29/16 ,  C12M29/20 ,  C12M41/48 ,  G06F8/38

    摘要： Embodiments described herein generally relate to methods and systems for using an air removal chamber as a control for a process in a cell expansion system. The air removal chamber may be mounted on a fluid conveyance assembly for use with the system. Fluid is pumped into a fluid containment chamber of the air removal chamber, in which the level of fluid in the fluid containment chamber may be monitored through the use of one or more sensors. The sensors are capable of detecting air, a lack of fluid, fluid, and/or a gas/fluid interface, e.g., an air/fluid interface, at measuring positions within the air removal chamber. Protocols for use with the system may include one or more stop conditions. In an embodiment, the stopping of a process is automated based on the detection of air, a lack of fluid, and/or a gas/fluid interface in the air removal chamber.

    摘要翻译： 本文描述的实施例一般涉及使用空气除去室作为电池膨胀系统中的工艺的控制的方法和系统。 排气室可以安装在流体输送组件上以与系统一起使用。 流体被泵送到空气移除室的流体容纳室中，其中流体容纳室中的流体水平可以通过使用一个或多个传感器来监测。 传感器能够在空气去除室内的测量位置处检测空气，缺乏流体，流体和/或气体/流体界面，例如空气/流体界面。 用于该系统的协议可以包括一个或多个停止条件。 在一个实施例中，基于在空气移除室中检测空气，缺乏流体和/或气体/流体界面，自动停止过程。

    Customizable Methods and Systems of Growing and Harvesting Cells in a Hollow Fiber Bioreactor System
    4.
    发明申请
    Customizable Methods and Systems of Growing and Harvesting Cells in a Hollow Fiber Bioreactor System 审中-公开

    公开(公告)号：US20170267966A1

    公开(公告)日：2017-09-21

    申请号：US15610224

    申请日：2017-05-31

    申请人： Terumo BCT, Inc.

    发明人： Edward Allan STANTON, IV ,  Glen Delbert ANTWILER ,  Patrick J. HOWLEY ,  Michael E. KINZIE ,  Jon A. DODD ,  Casey V. MEDINA

    IPC分类号： C12M1/34 ,  C12M3/00

    摘要： Embodiments described herein generally relate to methods and systems for customizing protocols for use with a cell expansion system. Through a user interface, a user may create a custom task for loading, growing and/or harvesting cells. A custom task may comprise one or more steps, in which a user may add or omit steps, as desired. Data may be entered for settings associated with a custom task, in which embodiments provide for such data to be entered each time the custom task is performed. In another embodiment, the settings for a custom task may be configured, in which such settings may be stored and retrieved upon selection of the custom task. Customization and configuration of a custom task may occur using a diagram view of the cell expansion system, in which process settings are associated with graphical user interface elements.