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公开(公告)号：US20210401984A1
公开(公告)日：2021-12-30
申请号：US17477725
申请日：2021-09-17
发明人： Robert Francis GARRY , Luis Manuel BRANCO , Bruce Alan BUNNELL , Russell B. WILSON , Samuel E. HOPKINS
IPC分类号： A61K39/42 , A61K35/28 , C12N5/0775 , C07K16/10 , G01N33/68
摘要： Immunoprotective primary mesenchymal stems cells (IP-MSC) which episomally express immunoreactive polypeptides that specifically target a pathogen (e.g., an infectious species of virus, bacterium, or parasite) or toxin are described herein. The immunoreactive polypeptides can be, e.g., full antibodies, single-chain antibodies (ScFV), Fab or F(ab)2 antibody fragments, diabodies, tribodies, and the like). Optionally IP-MSC are trasfected to express one or more other immunomodulating polypeptides, e.g., a cytokine such as an interleukin (e.g., IL-2, IL-4, IL-6, IL-7, IL-9, and IL-12), an interferon (e.g., IFNα, IFβ, or IFNω), and the like, which can enhance the effectiveness of the immunoreactive polypeptides.
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公开(公告)号：US20160129110A1
公开(公告)日：2016-05-12
申请号：US14802247
申请日：2015-07-17
发明人： Robert Francis GARRY , Luis Manuel BRANCO , Bruce Alan BUNNELL , Russell B. WILSON , Samuel E. HOPKINS
CPC分类号： A61K39/42 , A61K35/28 , C07K16/10 , C07K2317/76 , C12N5/0667 , C12N2510/00 , G01N33/6854 , Y02A50/387 , Y02A50/389 , Y02A50/393 , Y02A50/395 , Y02A50/402 , Y02A50/406 , Y02A50/409 , Y02A50/411 , Y02A50/421 , Y02A50/423 , Y02A50/463 , Y02A50/465 , Y02A50/469 , Y02A50/471 , Y02A50/475 , Y02A50/478 , Y02A50/48 , Y02A50/481 , Y02A50/491
摘要： Immunoprotective primary mesenchymal stems cells (IP-MSC) which episomally express multiple immunoreactive polypeptides that specifically target a pathogen (e.g., an infectious species of virus, bacterium, or parasite) or toxin are described herein. The IP-MSC express two or more (e.g., 2 to about 100) immunoreactive polypeptides (e.g., full antibodies, single-chain antibodies (ScFV), Fab or F(ab)2 antibody fragments, diabodies, tribodies, and the like), and optionally one or more other immunomodulating polypeptides, e.g., a cytokine such as an interleukin (e.g., IL-2, IL-4, IL-6, IL-7, IL-9, and IL-12), an interferon (e.g., IFNα, IFNβ, or IFNω), and the like, which can enhance the effectiveness of the immunoreactive polypeptides.
摘要翻译： 本文描述了附加表达特异性靶向病原体（例如病毒，细菌或寄生虫）或毒素的感染物种的多种免疫反应性多肽的免疫保护性原代间充质干细胞（IP-MSC）。 IP-MSC表达两种或更多种（例如，2至约100）免疫反应性多肽（例如，全抗体，单链抗体（ScFV），Fab或F（ab）2抗体片段，双抗体，抗体等） ，和任选的一种或多种其它免疫调节多肽，例如细胞因子如白细胞介素（例如IL-2，IL-4，IL-6，IL-7，IL-9和IL-12），干扰素 例如IFNα，IFN和bgr，或IFNω）等，其可增强免疫反应性多肽的有效性。
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公开(公告)号：US20140271580A1
公开(公告)日：2014-09-18
申请号：US13826285
申请日：2013-03-14
发明人： Robert Francis GARRY , Luis Manuel BRANCO , Bruce Alan BUNNELL , Russell B. WILSON , Samuel E. HOPKINS
IPC分类号： A61K35/28
CPC分类号： A61K39/42 , A61K35/28 , C07K16/10 , C07K2317/76 , C12N5/0667 , C12N2510/00 , G01N33/6854 , Y02A50/387 , Y02A50/389 , Y02A50/393 , Y02A50/395 , Y02A50/402 , Y02A50/406 , Y02A50/409 , Y02A50/411 , Y02A50/421 , Y02A50/423 , Y02A50/463 , Y02A50/465 , Y02A50/469 , Y02A50/471 , Y02A50/475 , Y02A50/478 , Y02A50/48 , Y02A50/481 , Y02A50/491
摘要： Immunoprotective primary mesenchymal stems cells (IP-MSC) which episomally express multiple immunoreactive polypeptides that specifically target a pathogen (e.g., an infectious species of virus, bacterium, or parasite) or toxin are described herein. The IP-MSC express two or more (e.g., 2 to about 100) immunoreactive polypeptides (e.g., full antibodies, single-chain antibodies (ScFV), Fab or F(ab)2 antibody fragments, diabodies, tribodies, and the like), and optionally one or more other immunomodulating polypeptides, e.g., a cytokine such as an interleukin (e.g., IL-2, IL-4, IL-6, IL-7, IL-9, and IL-12), an interferon (e.g., IFNα, IFNβ, or IFNω), and the like, which can enhance the effectiveness of the immunoreactive polypeptides.
摘要翻译： 本文描述了附加表达特异性靶向病原体（例如病毒，细菌或寄生虫）或毒素的感染物种的多种免疫反应性多肽的免疫保护性原代间充质干细胞（IP-MSC）。 IP-MSC表达两种或更多种（例如，2至约100）免疫反应性多肽（例如，全抗体，单链抗体（ScFV），Fab或F（ab）2抗体片段，双抗体，抗体等） ，和任选的一种或多种其它免疫调节多肽，例如细胞因子如白细胞介素（例如IL-2，IL-4，IL-6，IL-7，IL-9和IL-12），干扰素 例如IFNα，IFN和bgr，或IFNω）等，其可增强免疫反应性多肽的有效性。
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