公开(公告)号：US09593080B1

公开(公告)日：2017-03-14

申请号：US15224446

申请日：2016-07-29

Applicant: THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA

Inventor： John C. Jewett ,  Flora W. Kimani ,  Lindsay Guzman ,  Brandon M. Cornali

IPC: C08G59/00 ,  C07D233/88 ,  C07D403/12 ,  C07D405/12 ,  C07D413/14 ,  G01N33/68 ,  A61K47/48 ,  G01N33/569

CPC classification number: C07D233/88 ,  A61K47/545 ,  C07D235/30 ,  C07D277/50 ,  C07D277/82 ,  C07D403/12 ,  C07D405/12 ,  C07D413/14 ,  C09B26/06 ,  C09J163/00 ,  G01N33/56983 ,  G01N33/6845

Abstract: Triazabutadiene molecules as cleavable cross-linkers adapted to cross-link components with click chemistry, e.g., clickable triazabutadienes. For example, in some embodiments, the triazabutadienes feature alkyne handles attached to the imidazole portion or the aryl portion of the triazabutadienes, wherein the alkyne handles can link to azide handles (e.g., azide handles disposed on other components) via click chemistry. Also described are methods of producing said clickable triazabutadienes and methods of use of said clickable triazabutadienes. The present invention also features methods of cleaving said clickable triazabutadienes, e.g., for liberating the diazonium species for further chemical reactions.

Abstract translation: 三唑二丁烯分子作为可切割交联剂，其适于使用点击化学交联组分，例如可点击的三氮杂二萘嵌苯。 例如，在一些实施方案中，三唑类物质特征是连接到咪唑部分或三氮杂双环的芳基部分的炔柄，其中炔手柄可以通过点击化学连接到叠氮化物手柄（例如，设置在其它组分上的叠氮化物手柄）。 还描述了生产所述可点击的三氮杂双环网的方法和所述可点击的三氮杂双环网的使用方法。 本发明还具有切割所述可点击的三氮杂异二烯的方法，例如用于释放重氮物质用于进一步的化学反应。

公开(公告)号：US20170320834A1

公开(公告)日：2017-11-09

申请号：US15427988

申请日：2017-02-08

Applicant: THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA

Inventor： John C. Jewett ,  Flora W. Kimani ,  Lindsay Guzman ,  Brandon M. Cornali

IPC: C07D233/88 ,  C07D405/12 ,  C07D403/12 ,  C09B62/78 ,  C09K11/06

CPC classification number: C07D233/88 ,  A61K47/545 ,  A61K49/0021 ,  C07D403/12 ,  C07D405/12 ,  C07D413/14 ,  C07H21/00 ,  C09B26/06 ,  C09B55/003 ,  C09J163/00 ,  C09K11/06 ,  C09K2211/1048 ,  G01N33/56983 ,  G01N33/6845

Abstract: Triazabutadiene molecules as cleavable cross-linkers adapted to cross-link components with dick chemistry, e.g., clickable triazabutadienes. For example, in some embodiments, the triazabutadienes feature alkyne handles attached to the imidazole portion or the aryl portion of the triazabutadienes, wherein the alkyne handles can link to azide handles (e.g., azide handles disposed on other components) via dick chemistry. Also described are methods of producing said clickable triazabutadienes and methods of use of said clickable triazabutadienes. The present invention also features methods of cleaving said clickable triazabutadienes, e.g., for liberating the diazonium species for further chemical reactions.

公开(公告)号：US09458143B1

公开(公告)日：2016-10-04

申请号：US14918287

申请日：2015-10-20

Applicant: THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA

Inventor： John C. Jewett ,  Flora W. Kimani

IPC: C08G59/00 ,  C07D405/12 ,  C07D233/88 ,  C07D277/50 ,  C07D235/30 ,  C07D277/82 ,  C09J163/00

CPC classification number: C07D277/82 ,  C07C245/06 ,  C07D233/70 ,  C07D233/88 ,  C07D235/30 ,  C07D277/50 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C09B26/06 ,  C09B43/00 ,  C09J11/06 ,  C09J163/00 ,  C09J201/06 ,  C09J2201/614 ,  G01N33/6845

Abstract: Triazabutadiene molecules that provide adhesive functionality, e.g., triazabutadiene molecules as underwater adhesives or water-reactive adhesives. The triazabutadiene molecules mask an aryl diazonium ion, a highly reactive chemical functionality. Once unmasked, e.g., in water, the diazonium species is adapted to react with an electron rich aryl ring that can undergo diazonium chemistry (e.g., phenol species, resorcinol species, etc.). Triazabutadienes can be used as additives in adhesive systems such as but not limited to epoxy adhesive systems.

Abstract translation: 提供粘合功能性的三氮杂双丁烯分子，例如作为水下粘合剂的三氮杂二丁苯分子或水反应性粘合剂。 三唑二丁烯分子掩蔽了芳基重氮离子，一种高反应性的化学官能团。 一旦未掩蔽，例如在水中，重氮物质适于与可以经历重氮化学的富电子芳基环（例如苯酚类，间苯二酚类等）反应。 三氮杂双环可用作粘合剂系统中的添加剂，例如但不限于环氧树脂粘合剂体系。

公开(公告)号：US20170114033A1

公开(公告)日：2017-04-27

申请号：US15317894

申请日：2015-06-10

Applicant: The Arizona Board of Regents on Behalf of The University of Arizona

Inventor： John C. Jewett ,  Flora W. Kimani

IPC: C07D277/82 ,  C07C245/06 ,  C07D233/70 ,  C07D277/50 ,  C09B43/00 ,  C07D403/12 ,  C09J11/06 ,  C09J201/06 ,  G01N33/68 ,  C07D233/88 ,  C07D235/30

CPC classification number: C07D277/82 ,  C07C245/06 ,  C07D233/70 ,  C07D233/88 ,  C07D235/30 ,  C07D277/50 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C09B26/06 ,  C09B43/00 ,  C09J11/06 ,  C09J163/00 ,  C09J201/06 ,  C09J2201/614 ,  G01N33/6845

Abstract: Water-soluble triazabutadiene molecules and methods for producing and using such compounds. The triazabutadiene molecules may be more labile at pH levels below physiological pH, such as pH 7, pH 6, pH 5, etc. The triazabutadiene molecules and compounds may be used for depositing diazonium salt and/or cargo in a pH-sensitive manner. The triazabutadiene molecules may alternatively be cleaved in reducing conditions or as a light-catalyzed reaction. The compounds herein may be used for delivery of drugs, as part of detection systems, or for other applications such as underwater adhesive applications.