公开(公告)号：US20210228880A1

公开(公告)日：2021-07-29

申请号：US17154045

申请日：2021-01-21

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： Andre Machado ,  Raghavan Gopalakrishnan ,  Kenneth Baker

IPC: A61N1/36 ,  A61N1/05

Abstract: Deep brain stimulation (DBS) can be used to treat many neurological conditions beyond traditional movement disorders. When patients do not suffer from traditional movement disorders, medical professionals cannot use traditional observation-based methods to configure the DBS system. A new method for selecting stimulation configurations can include recording internal data and external data as the patient performs (or attempts to perform) a motor task. The internal data is electrophysiology data recorded by a plurality of DBS electrodes, used to identify at least one of the plurality of electrodes closest to a neuronal population involved in control of the at least one motor task. The external data is electroencephalogram (EEG) data recorded by scalp electrodes, which is used to select at least one of the potential stimulation electrodes to deliver the DBS. When the electrode(s) delivering the DBS are selected, optimal parameters for the DBS are then chosen.

公开(公告)号：US20250121190A1

公开(公告)日：2025-04-17

申请号：US18986810

申请日：2024-12-19

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： Andre Machado ,  Raghavan Gopalakrishnan ,  Kenneth Baker

IPC: A61N1/36 ,  A61N1/05

Abstract: Deep brain stimulation (DBS) can be used to treat many neurological conditions beyond traditional movement disorders. When patients do not suffer from traditional movement disorders, medical professionals cannot use traditional observation-based methods to configure the DBS system. A new method for selecting stimulation configurations can include recording internal data and external data as the patient performs (or attempts to perform) a motor task. The internal data is electrophysiology data recorded by a plurality of DBS electrodes, used to identify at least one of the plurality of electrodes closest to a neuronal population involved in control of the at least one motor task. The external data is electroencephalogram (EEG) data recorded by scalp electrodes, which is used to select at least one of the potential stimulation electrodes to deliver the DBS. When the electrode(s) delivering the DBS are selected, optimal parameters for the DBS are then chosen.

公开(公告)号：US20130338726A1

公开(公告)日：2013-12-19

申请号：US13776875

申请日：2013-02-26

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： Andre Machado

IPC: A61N1/36

CPC classification number: A61N1/36025 ,  A61B5/04001 ,  A61B5/1118 ,  A61N1/0529 ,  A61N1/0534 ,  A61N1/36017 ,  A61N1/36067 ,  A61N1/36103 ,  A61N1/36189

Abstract: A neurostimulation system can include a memory, a playback system, a stimulation electrode, and a controller. The memory can store data for first and second input waveforms. The playback system can provides first and second output waveforms, based on the first and second input waveforms in the memory, respectively, to form composite patterns of stimulation or waveforms. The first output waveform can be different than the second output waveform. The second output waveform can be periodically superimposed on the first output waveform. The controller can be in communication with the stimulation electrode. The controller can be configured to control application of the composite pattern of stimulation or waveform to a target site in a body of a subject suffering from a medical condition.

Abstract translation: 神经刺激系统可以包括存储器，回放系统，刺激电极和控制器。 存储器可以存储第一和第二输入波形的数据。 播放系统可以分别基于存储器中的第一和第二输入波形提供第一和第二输出波形，以形成刺激或波形的复合图案。 第一个输出波形可以与第二个输出波形不同。 第二输出波形可以周期地叠加在第一输出波形上。 控制器可以与刺激电极连通。 控制器可以被配置为控制刺激或波形的复合图案的应用到患有医疗状况的受试者的身体中的目标部位。

公开(公告)号：US12194297B2

公开(公告)日：2025-01-14

申请号：US17154045

申请日：2021-01-21

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： Andre Machado ,  Raghavan Gopalakrishnan ,  Kenneth Baker

IPC: A61N1/36 ,  A61N1/05

Abstract: Deep brain stimulation (DBS) can be used to treat many neurological conditions beyond traditional movement disorders. When patients do not suffer from traditional movement disorders, medical professionals cannot use traditional observation-based methods to configure the DBS system. A new method for selecting stimulation configurations can include recording internal data and external data as the patient performs (or attempts to perform) a motor task. The internal data is electrophysiology data recorded by a plurality of DBS electrodes, used to identify at least one of the plurality of electrodes closest to a neuronal population involved in control of the at least one motor task. The external data is electroencephalogram (EEG) data recorded by scalp electrodes, which is used to select at least one of the potential stimulation electrodes to deliver the DBS. When the electrode(s) delivering the DBS are selected, optimal parameters for the DBS are then chosen.

公开(公告)号：US09211408B2

公开(公告)日：2015-12-15

申请号：US13776875

申请日：2013-02-26

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： Andre Machado

IPC: A61N1/36 ,  A61N1/05 ,  A61B5/04 ,  A61B5/11

CPC classification number: A61N1/36025 ,  A61B5/04001 ,  A61B5/1118 ,  A61N1/0529 ,  A61N1/0534 ,  A61N1/36017 ,  A61N1/36067 ,  A61N1/36103 ,  A61N1/36189

Abstract: A neurostimulation system can include a memory, a playback system, a stimulation electrode, and a controller. The memory can store data for first and second input waveforms. The playback system can provides first and second output waveforms, based on the first and second input waveforms in the memory, respectively, to form composite patterns of stimulation or waveforms. The first output waveform can be different than the second output waveform. The second output waveform can be periodically superimposed on the first output waveform. The controller can be in communication with the stimulation electrode. The controller can be configured to control application of the composite pattern of stimulation or waveform to a target site in a body of a subject suffering from a medical condition.

Abstract translation: 神经刺激系统可以包括存储器，回放系统，刺激电极和控制器。 存储器可以存储第一和第二输入波形的数据。 播放系统可以分别基于存储器中的第一和第二输入波形提供第一和第二输出波形，以形成刺激或波形的复合图案。 第一个输出波形可以与第二个输出波形不同。 第二输出波形可以周期地叠加在第一输出波形上。 控制器可以与刺激电极连通。 控制器可以被配置为控制刺激或波形的复合图案的应用到患有医疗状况的受试者的身体中的目标部位。

公开(公告)号：US09186095B2

公开(公告)日：2015-11-17

申请号：US14024368

申请日：2013-09-11

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： Andre Machado ,  Jay L. Alberts ,  Cameron McIntyre ,  David Schindler

IPC: A61B5/11 ,  A61B5/00

CPC classification number: A61B5/4082 ,  A61B5/0015 ,  A61B5/0022 ,  A61B5/11 ,  A61B5/1101 ,  A61B5/1124 ,  A61B5/1126 ,  A61B5/6897 ,  A61B2562/0219 ,  A61B2562/0223

Abstract: This disclosure relates to a system and method to evaluate movement disorders. A movement data aggregator can combine data from a plurality of sensors into an aggregate movement data describing multi-dimensional movement of a handheld device. A calculator to compute an indication of a movement disorder based on the movement vector data and user input data, the user input data being generated in response to physical interaction between the handheld device and a human machine interface of a computing device/machine that is separate from the handheld device. In some examples, the handheld device can communicate with computing device via a wireless interface.

Abstract translation: 本公开涉及评估运动障碍的系统和方法。 移动数据聚合器可以将来自多个传感器的数据组合成描述手持设备的多维运动的聚集移动数据。 一种计算器，用于基于所述移动向量数据和用户输入数据来计算运动障碍的指示，所述用户输入数据是响应于所述手持设备与分离的计算设备/机器的人机界面之间的物理交互而产生的 从手持设备。 在一些示例中，手持设备可以经由无线接口与计算设备进行通信。

公开(公告)号：US08942812B2

公开(公告)日：2015-01-27

申请号：US13857815

申请日：2013-04-05

Applicant: The Cleveland Clinic Foundation

Inventor： Andre Machado ,  Ali R. Rezai

IPC: A61N1/36 ,  A61N1/05

CPC classification number: A61N1/0531 ,  A61N1/0534 ,  A61N1/0539 ,  A61N1/3605 ,  A61N1/36082

Abstract: Neuromodulation assemblies with lead bodies having curvatures that mimic the curvatures of the splenium, trunk, genu, or rostrum of the corpus callosum. Methods of stimulating the corpus callosum and methods of securing an electrical lead in the brain are also provided.

Abstract translation: 具有引导体的神经调节组件具有模拟胼the体的脾，躯干，g或者讲台的曲率的曲率。 还提供了刺激胼the体的方法和将电铅固定在脑中的方法。

公开(公告)号：US20140073994A1

公开(公告)日：2014-03-13

申请号：US14024368

申请日：2013-09-11

Applicant: The Cleveland Clinic Foundation

Inventor： Andre Machado ,  Jay L. Alberts ,  Cameron McIntyre ,  David Schindler

IPC: A61B5/11

CPC classification number: A61B5/4082 ,  A61B5/0015 ,  A61B5/0022 ,  A61B5/11 ,  A61B5/1101 ,  A61B5/1124 ,  A61B5/1126 ,  A61B5/6897 ,  A61B2562/0219 ,  A61B2562/0223

Abstract: This disclosure relates to a system and method to evaluate movement disorders. A movement data aggregator can combine data from a plurality of sensors into an aggregate movement data describing multi-dimensional movement of a handheld device. A calculator to compute an indication of a movement disorder based on the movement vector data and user input data, the user input data being generated in response to physical interaction between the handheld device and a human machine interface of a computing device/machine that is separate from the handheld device. In some examples, the handheld device can communicate with computing device via a wireless interface.

Abstract translation: 本公开涉及评估运动障碍的系统和方法。 运动数据聚合器可以将来自多个传感器的数据组合成描述手持设备的多维运动的聚集移动数据。 一种计算器，用于基于所述移动向量数据和用户输入数据来计算运动障碍的指示，所述用户输入数据是响应于所述手持设备与分离的计算设备/机器的人机界面之间的物理交互而产生的 从手持设备。 在一些示例中，手持设备可以经由无线接口与计算设备进行通信。