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1.发明授权公开(公告)号：US09480790B2
公开(公告)日：2016-11-01
申请号：US14085311
申请日：2013-11-20
Applicant: The Cleveland Clinic Foundation
Inventor： Sandra Machado , Marc Penn , Ali R. Rezai
CPC classification number: A61N1/0565 , A61B18/1492 , A61B2018/00267 , A61B2018/00351 , A61B2018/00577 , A61B2018/00648 , A61B2018/00827 , A61B2018/00892 , A61M5/14212 , A61N1/0568 , A61N1/36114 , A61N1/3627 , A61N1/36585
Abstract: Methods of treating acute heart failure in a patient in need thereof. Methods include inserting a therapy delivery device into a pulmonary artery of the patient and applying a therapy signal to autonomic cardiopulmonary fibers surrounding the pulmonary artery. The therapy signal affects heart contractility more than heart rate. Specifically, the application of the therapy signal increases heart contractility and treats the acute heart failure in the patient. The therapy signal can include electrical or chemical modulation.
Abstract translation: 在有需要的患者中治疗急性心力衰竭的方法。 方法包括将治疗递送装置插入到患者的肺动脉中，并将治疗信号施加到围绕肺动脉的自主心肺纤维。 治疗信号影响心脏收缩力超过心率。 具体来说，治疗信号的应用增加了心脏收缩力，并治疗了患者的急性心力衰竭。 治疗信号可以包括电或化学调节。
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公开(公告)号：US20140052214A1
公开(公告)日：2014-02-20
申请号：US14064447
申请日：2013-10-28
Applicant: THE CLEVELAND CLINIC FOUNDATION
Inventor： Ali R. Rezai
IPC: A61N1/36
CPC classification number: A61N1/36082 , A61B5/4035 , A61B5/411 , A61B5/415 , A61B5/418 , A61M5/00 , A61N1/0551 , A61N1/36021 , A61N1/36071 , A61N1/36085 , A61N1/36089 , A61N1/3611
Abstract: The present invention provides a method of effecting physiological disorders by stimulating a specific location along the sympathetic nerve chain. Preferably, the present invention provides a method of effecting a variety of physiological disorders or pathological conditions by placing an electrode adjacent to or in communication with at least one ganglion along the sympathetic nerve chain and stimulating the at least one ganglion until the physiological disorder or pathological condition has been effected.
Abstract translation: 本发明提供通过刺激交感神经链的特定位置来实现生理障碍的方法。 优选地，本发明提供了通过将电极与交感神经链邻近或与至少一个神经节连通并且与至少一个神经节连通并刺激至少一个神经节直到生理障碍或病理学的方式来实现各种生理学障碍或病理状况 条件已经实现。
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公开(公告)号：US20180147408A1
公开(公告)日：2018-05-31
申请号：US15879694
申请日：2018-01-25
Applicant: The Cleveland Clinic Foundation
Inventor： Sandra Machado , Marc Penn , Ali R. Rezai
CPC classification number: A61N1/0565 , A61B18/1492 , A61B2018/00267 , A61B2018/00351 , A61B2018/00577 , A61B2018/00648 , A61B2018/00827 , A61B2018/00892 , A61M5/14212 , A61N1/0568 , A61N1/36114 , A61N1/3627 , A61N1/36585
Abstract: Methods of treating acute heart failure in a patient in need thereof. Methods include inserting a therapy delivery device into a pulmonary artery of the patient and applying a therapy signal to autonomic cardiopulmonary fibers surrounding the pulmonary artery. The therapy signal affects heart contractility more than heart rate. Specifically, the application of the therapy signal increases heart contractility and treats the acute heart failure in the patient. The therapy signal can include electrical or chemical modulation.
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4.发明申请公开(公告)号：US20130172953A1
公开(公告)日：2013-07-04
申请号：US13654525
申请日：2012-10-18
Applicant: THE CLEVELAND CLINIC FOUNDATION
Inventor： Sandra Machado , Marc Penn , Ali R. Rezai
CPC classification number: A61N1/0565 , A61B18/1492 , A61B2018/00267 , A61B2018/00351 , A61B2018/00577 , A61B2018/00648 , A61B2018/00827 , A61B2018/00892 , A61M5/14212 , A61N1/0568 , A61N1/36114 , A61N1/3627 , A61N1/36585
Abstract: Methods of treating acute heart failure in a patient in need thereof. Methods include inserting a therapy delivery device into a pulmonary artery of the patient and applying a therapy signal to autonomic cardiopulmonary fibers surrounding the pulmonary artery. The therapy signal affects heart contractility more than heart rate. Specifically, the application of the therapy signal increases heart contractility and treats the acute heart failure in the patient. The therapy signal can include electrical or chemical modulation.
Abstract translation: 在有需要的患者中治疗急性心力衰竭的方法。 方法包括将治疗递送装置插入到患者的肺动脉中，并将治疗信号施加到围绕肺动脉的自主心肺纤维。 治疗信号影响心脏收缩力超过心率。 具体来说，治疗信号的应用增加了心脏收缩力，并治疗了患者的急性心力衰竭。 治疗信号可以包括电或化学调节。
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5.发明申请公开(公告)号：US20160067491A1
公开(公告)日：2016-03-10
申请号：US14945518
申请日：2015-11-19
Inventor： Ali R. Rezai , Anthony V. Caparso , Benjamin D. Pless
CPC classification number: A61N1/3611 , A61B5/0205 , A61B5/04001 , A61B5/1473 , A61B5/4029 , A61B5/4058 , A61B5/4836 , A61B5/6877 , A61M5/14276 , A61M5/1723 , A61M2205/50 , A61N1/0551 , A61N1/36021 , A61N1/36071
Abstract: The present invention is directed to a method of treating a respiratory or pulmonary condition in a patient by transvascular neuromodulation of an adrenal gland or neural structures that innervate the adrenal gland or components thereof. Methods also include implanting a controller in the patient to control delivery of a therapy signal to the patient's adrenal gland. The therapy signal can be an electrical and/or chemical signal.
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Patent Agency Ranking
6.发明授权公开(公告)号：US08798738B2
公开(公告)日：2014-08-05
申请号：US13654525
申请日：2012-10-18
Applicant: The Cleveland Clinic Foundation
Inventor： Sandra Machado , Marc Penn , Ali R. Rezai
IPC: A61N1/365
CPC classification number: A61N1/0565 , A61B18/1492 , A61B2018/00267 , A61B2018/00351 , A61B2018/00577 , A61B2018/00648 , A61B2018/00827 , A61B2018/00892 , A61M5/14212 , A61N1/0568 , A61N1/36114 , A61N1/3627 , A61N1/36585
Abstract: Methods of treating acute heart failure in a patient in need thereof. Methods include inserting a therapy delivery device into a pulmonary artery of the patient and applying a therapy signal to autonomic cardiopulmonary fibers surrounding the pulmonary artery. The therapy signal affects heart contractility more than heart rate. Specifically, the application of the therapy signal increases heart contractility and treats the acute heart failure in the patient. The therapy signal can include electrical or chemical modulation.
Abstract translation: 在有需要的患者中治疗急性心力衰竭的方法。 方法包括将治疗递送装置插入到患者的肺动脉中，并将治疗信号施加到围绕肺动脉的自主心肺纤维。 治疗信号影响心脏收缩力超过心率。 具体来说，治疗信号的应用增加了心脏收缩力，并治疗了患者的急性心力衰竭。 治疗信号可以包括电或化学调节。
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公开(公告)号：US20210154470A1
公开(公告)日：2021-05-27
申请号：US17248634
申请日：2021-02-01
Applicant: The Cleveland Clinic Foundation
Inventor： Sandra Machado , Marc Penn , Ali R. Rezai
Abstract: Methods of treating acute heart failure in a patient in need thereof. Methods include inserting a therapy delivery device into a pulmonary artery of the patient and applying a therapy signal to autonomic cardiopulmonary fibers surrounding the pulmonary artery. The therapy signal affects heart contractility more than heart rate. Specifically, the application of the therapy signal increases heart contractility and treats the acute heart failure in the patient. The therapy signal can include electrical or chemical modulation.
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公开(公告)号：US11986650B2
公开(公告)日：2024-05-21
申请号：US17248634
申请日：2021-02-01
Applicant: The Cleveland Clinic Foundation
Inventor： Sandra Machado , Marc Penn , Ali R. Rezai
CPC classification number: A61N1/0565 , A61B18/1492 , A61M5/14212 , A61N1/0568 , A61N1/36114 , A61N1/3627 , A61N1/36585 , A61B2018/00267 , A61B2018/00351 , A61B2018/00577 , A61B2018/00648 , A61B2018/00827 , A61B2018/00892
Abstract: Methods of treating acute heart failure in a patient in need thereof. Methods include inserting a therapy delivery device into a pulmonary artery of the patient and applying a therapy signal to autonomic cardiopulmonary fibers surrounding the pulmonary artery. The therapy signal affects heart contractility more than heart rate. Specifically, the application of the therapy signal increases heart contractility and treats the acute heart failure in the patient. The therapy signal can include electrical or chemical modulation.
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公开(公告)号：US10905873B2
公开(公告)日：2021-02-02
申请号：US15879694
申请日：2018-01-25
Applicant: The Cleveland Clinic Foundation
Inventor： Sandra Machado , Marc Penn , Ali R. Rezai
Abstract: Methods of treating acute heart failure in a patient in need thereof. Methods include inserting a therapy delivery device into a pulmonary artery of the patient and applying a therapy signal to autonomic cardiopulmonary fibers surrounding the pulmonary artery. The therapy signal affects heart contractility more than heart rate. Specifically, the application of the therapy signal increases heart contractility and treats the acute heart failure in the patient. The therapy signal can include electrical or chemical modulation.
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公开(公告)号：US09878150B2
公开(公告)日：2018-01-30
申请号：US15334121
申请日：2016-10-25
Applicant: The Cleveland Clinic Foundation
Inventor： Sandra Machado , Marc Penn , Ali R. Rezai
CPC classification number: A61N1/0565 , A61B18/1492 , A61B2018/00267 , A61B2018/00351 , A61B2018/00577 , A61B2018/00648 , A61B2018/00827 , A61B2018/00892 , A61M5/14212 , A61N1/0568 , A61N1/36114 , A61N1/3627 , A61N1/36585
Abstract: Methods of treating acute heart failure in a patient in need thereof. Methods include inserting a therapy delivery device into a pulmonary artery of the patient and applying a therapy signal to autonomic cardiopulmonary fibers surrounding the pulmonary artery. The therapy signal affects heart contractility more than heart rate. Specifically, the application of the therapy signal increases heart contractility and treats the acute heart failure in the patient. The therapy signal can include electrical or chemical modulation.
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