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    CHEMICAL INHIBITORS AGAINST KINASES TO BLOCK TELOMERE ELONGATION IN CANCER
    2.
    发明申请
    CHEMICAL INHIBITORS AGAINST KINASES TO BLOCK TELOMERE ELONGATION IN CANCER 审中-公开

    公开(公告)号：US20200078387A1

    公开(公告)日：2020-03-12

    申请号：US16469615

    申请日：2017-12-15

    申请人： THE JOHNS HOPKINS UNIVERSITY

    发明人： Carol W. Greider ,  Steven Wang

    IPC分类号： A61K31/7076 ,  G01N33/50 ,  A61K31/4439 ,  A61K31/4045 ,  A61K31/5377 ,  A61K31/551 ,  A61K31/655 ,  A61K31/4745 ,  A61K31/5025 ,  C12Q1/48 ,  A61K31/4725 ,  A61K31/519

    摘要： The present invention relates generally to chromosome maintenance and cell viability, and more specifically, to the identification of kinases the inhibition of which blocks telomere elongation. In one aspect, the present invention provides methods for treating cancer. The methods generally comprise the administration of agents that interfere with the lengthening of telomeres in cancer. In a specific embodiment, a method of treating cancer in a subject by interfering with lengthening of telomeres in cancer cells comprises administering to the cells an effective amount of an inhibitor of casein kinase 1 (CK1), wherein the administration of the inhibitor leads to progressive telomere shortening in the cancer cell, thereby treating cancer in the subject. In another embodiment, the method can further comprise administering to the cells an effective amount of an inhibitor of bromodomain-containing protein 4 (BRD4) and/or an inhibitor of the MEK/ERK pathway.