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    CHEMICAL REPROGRAMMING OF HUMAN GLIAL CELLS INTO NEURONS FOR BRAIN AND SPINAL CORD REPAIR
    2.
    发明申请
    CHEMICAL REPROGRAMMING OF HUMAN GLIAL CELLS INTO NEURONS FOR BRAIN AND SPINAL CORD REPAIR 审中-公开

    公开(公告)号：US20200023030A1

    公开(公告)日：2020-01-23

    申请号：US16588054

    申请日：2019-09-30

    申请人： The Penn State Research Foundation

    发明人： Gong CHEN ,  Gang-Yi WU ,  Lei ZHANG ,  Jiu-Chao YIN ,  Hana YEH ,  Ning-Xin MA ,  Grace LEE

    IPC分类号： A61K38/05 ,  A61K31/519 ,  C12N5/0793 ,  A61K31/4439 ,  A61K31/506 ,  A61K31/00

    摘要： Provided are methods and compositions from reprogramming human glial cells into human neurons. The reprogramming is achieved using combinations of compounds that can modify signaling via Transforming growth factor beta (TGF-β), Bone morphogenetic protein (BMP), glycogen synthase kinase 3 (GSK-3), and γ-secretase/Notch pathways. The reprogramming is demonstrated using groups of three or four compounds that are chosen from the group thiazovivin, LDN193189, SB431542, TTNPB, CHIR99021, DAPT, VPA, SAG purmorphamine. Reprogramming is demonstrated using the group of LDN193189/CHIR99021/DAPT, the group of B431542/CHIR99021/DAPT, the group of LDN193189/DAPT/SB431542, the group of LDN193189/CHIR99021/SB431542, a three drug combination of SB431542/CHIR99021/DAPT. Reprogramming using functional analogs of the compounds is also provided, as are pharmaceutical formulations that contain the drug combinations.

    TRANSPARENT CONDUCTING FILMS INCLUDING COMPLEX OXIDES
    4.
    发明申请
    TRANSPARENT CONDUCTING FILMS INCLUDING COMPLEX OXIDES 审中-公开
    透明导电膜，包括复合氧化物

    公开(公告)号：US20160180982A1

    公开(公告)日：2016-06-23

    申请号：US14815546

    申请日：2015-07-31

    申请人： The Penn State Research Foundation

    发明人： Roman ENGEL-HERBERT ,  Lei ZHANG

    IPC分类号： H01B1/08 ,  C01G31/00 ,  C01G31/02 ,  C23C14/22 ,  C23C14/08

    CPC分类号： H01B1/08 ,  C01G31/006 ,  C01G31/02 ,  C01P2006/40 ,  C01P2006/60 ,  C23C14/08 ,  C23C14/22

    摘要： Transparent conducting films including an alkaline earth, transition metal oxide and their optimization of electrical conductivity and optical transparency by aliovalent substitution, which are useful as electrodes for semiconductors and other electronic devices are disclosed. Such materials include thin films of an aliovalent substituted transition metal oxides of Formula (I): A1-xA′xB1-yB′yO3-d (I) or a transition metal oxide of Formula (II): (ABO3-d)m(A′B′O3-d′)n.

    摘要翻译： 公开了包括碱土金属，过渡金属氧化物的透明导电膜及其通过用于半导体和其它电子器件的电极的通过二价取代的导电性和光学透明性的优化。 这样的材料包括式（I）的Aliovalent取代的过渡金属氧化物：Al-xA'xB1-yB'yO3-d（Ⅰ）或式（Ⅱ）的过渡金属氧化物的薄膜：（ABO3-d）m（ A'B'O3-d'）n。

    CHEMICAL REPROGRAMMING OF HUMAN GLIAL CELLS INTO NEURONS FOR BRAIN AND SPINAL CORD REPAIR
    5.
    发明申请
    CHEMICAL REPROGRAMMING OF HUMAN GLIAL CELLS INTO NEURONS FOR BRAIN AND SPINAL CORD REPAIR 有权

    公开(公告)号：US20210369808A1

    公开(公告)日：2021-12-02

    申请号：US17397927

    申请日：2021-08-09

    申请人： The Penn State Research Foundation

    发明人： Gong CHEN ,  Gang-Yi WU ,  Lei ZHANG ,  Jiu-Chao YIN ,  Hana YEH ,  Ning-Xin MA ,  Grace LEE

    IPC分类号： A61K38/05 ,  A61K31/519 ,  C12N5/0793 ,  A61K31/4439 ,  A61K31/506 ,  A61K31/00

    摘要： Provided are methods and compositions from reprogramming human glial cells into human neurons. The reprogramming is achieved using combinations of compounds that can modify signaling via Transforming growth factor beta (TGF-β), Bone morphogenetic protein (BMP), glycogen synthase kinase 3 (GSK-3), and γ-secretase/Notch pathways. The reprogramming is demonstrated using groups of three or four compounds that are chosen from the group thiazovivin, LDN193189, SB431542, TTNPB, CHIR99021, DAPT, VPA, SAG; purmorphamine. Reprogramming is demonstrated using the group of LDN193189/CHIR99021/DAPT, the group of B431542/CHIR99021/DAPT, the group of LDN193189/DAPT/SB431542, the group of LDN193189/CHIR99021/SB431542, a three drug combination of SB431542/CHIR99021/DAPT. Reprogramming using functional analogs of the compounds is also provided, as are pharmaceutical formulations that contain the drug combinations.

    CHEMICAL REPROGRAMMING OF HUMAN GLIAL CELLS INTO NEURONS FOR BRAIN AND SPINAL CORD REPAIR
    6.
    发明申请
    CHEMICAL REPROGRAMMING OF HUMAN GLIAL CELLS INTO NEURONS FOR BRAIN AND SPINAL CORD REPAIR 有权
    人类神经细胞在脑和脊髓修复神经中的化学分解

    公开(公告)号：US20160143984A1

    公开(公告)日：2016-05-26

    申请号：US14951723

    申请日：2015-11-25

    申请人： THE PENN STATE RESEARCH FOUNDATION

    发明人： Gong CHEN ,  Gang-Yi WU ,  Lei ZHANG ,  Jiu-Chao YIN ,  Hana YEH ,  Ning-Xin MA ,  Grace LEE

    IPC分类号： A61K38/05 ,  A61K31/506 ,  A61K31/4439 ,  A61K31/519 ,  C12N5/0793

    CPC分类号： A61K38/05 ,  A61K31/00 ,  A61K31/4439 ,  A61K31/506 ,  A61K31/519 ,  C12N5/0619 ,  C12N2501/15 ,  C12N2501/155 ,  C12N2501/727 ,  C12N2501/998 ,  C12N2501/999 ,  C12N2506/08

    摘要： Provided are methods and compositions from reprogramming human glial cells into human neurons. The reprogramming is achieved using combinations of compounds that can modify signaling via Transforming growth factor beta (TGF-β), Bone morphogenetic protein (BMP), glycogen synthase kinase 3 (GSK-3), and γ-secretase/Notch pathways. The reprogramming is demonstrated using groups of three or four compounds that are chosen from the group thiazovivin, LDN193189, SB431542, TTNPB, CHIR99021, DAPT, VPA, SAG, purmorphamine. Reprogramming is demonstrated using the group of LDN193189/CHIR99021/DAPT, the group of B431542/CHIR99021/DAPT, the group of LDN193189/DAPT/SB431542, the group of LDN193189/CHIR99021/SB431542, a three drug combination of SB431542/CHIR99021/DAPT. Reprogramming using functional analogs of the compounds is also provided, as are pharmaceutical formulations that contain the drug combinations.

    摘要翻译： 提供了将人神经胶质细胞重编程为人神经元的方法和组合物。 使用可以通过转化生长因子β（TGF-β），骨形态发生蛋白（BMP），糖原合成酶激酶3（GSK-3）和γ-分泌酶/缺口途径修饰信号传导的化合物的组合实现重编程。 使用三个或四个选自噻唑维丁，LDN193189，SB431542，TTNPB，CHIR99021，D​​APT，VPA，SAG，多变吗啡胺的化合物的组来证明重编程。 使用LDN193189 / CHIR99021 / DAPT组，B431542 / CHIR99021 / DAPT组，LDN193189 / DAPT / SB431542组，LDN193189 / CHIR99021 / SB431542组，SB431542 / CHIR99021 / DAPT的三种药物组合进行重编程 。 还提供使用化合物的功能类似物的重新编程，以及含有药物组合的药物制剂。