公开(公告)号：US10438346B2

公开(公告)日：2019-10-08

申请号：US15108279

申请日：2015-01-06

Applicant: The Regents of the University of California

Inventor： Kyle Nadeau ,  Anthony J. Durkin ,  Bruce J. Tromberg

IPC: G06K9/00 ,  G06T7/00 ,  G01B11/25 ,  A61B1/06 ,  G06K9/46 ,  G06T7/50 ,  G06T7/521 ,  G06T7/42

Abstract: The present invention relates to methods and devices that may be used to extract spatial frequency information. In one embodiment, the invention provides an instrument configured to extract data using a two-dimensional (2D) Hilbert transform technique, and providing spatial frequency information from a sample. In another embodiment, the invention provides a spatial frequency domain imaging (SFDI) device adapted for demodulation using two or less imaging frames.

公开(公告)号：US20160309068A1

公开(公告)日：2016-10-20

申请号：US15108271

申请日：2015-01-05

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Kyle Nadeau ,  Tyler B. Rice ,  Soren Konecky ,  Anthony J. Durkin ,  Bruce J. Tromberg

IPC: H04N5/225 ,  A61B1/06 ,  A61B1/00 ,  G01N21/64 ,  A61B5/026 ,  A61B1/04 ,  A61B5/00 ,  G01J3/28 ,  G01B11/25 ,  A61B5/1455

CPC classification number: H04N5/2256 ,  A61B1/00009 ,  A61B1/043 ,  A61B1/0669 ,  A61B1/0684 ,  A61B5/0073 ,  A61B5/0075 ,  A61B5/0261 ,  A61B5/1455 ,  A61B5/6826 ,  G01B11/2513 ,  G01J3/2846 ,  G01N21/4795 ,  G01N21/6456 ,  G01N21/6486

Abstract: The present invention relates to optical devices and methods of extracting optical properties, and depth and fluorescence information for visualizing samples. In one embodiment, the present invention provides a multi-frequency synthesis and extraction (MSE) method for quantitative tissue imaging. In another embodiment, the present invention provides a method of obtaining optical properties and depth information by illuminating a sample with binary square wave patterns of light, wherein a series of spatial frequency components are simultaneously attenuated and can be extracted. In another embodiment, the present invention provides an optical imaging apparatus comprising a Spatial Frequency Domain Imaging (SFDI) device modified to condense frequency information content into a single charged coupled device (CCD) frame, multi-pixel and/or single-pixel sensor using frequency-synthesized patterns.

Abstract translation: 本发明涉及提取光学特性的光学器件和方法，以及可视化样品的深度和荧光信息。 在一个实施方案中，本发明提供了用于定量组织成像的多频合成和提取（MSE）方法。 在另一个实施例中，本发明提供一种通过用二进制方波模式照亮样本来获得光学特性和深度信息的方法，其中一系列空间频率分量同时被衰减并且可被提取。 在另一个实施例中，本发明提供了一种光学成像设备，其包括被修改以将频率信息内容压缩到单个电荷耦合器件（CCD）帧中的空间频域成像（SFDI）器件，多像素和/或单像素传感器，其使用 频率合成模式。

公开(公告)号：US20160300348A1

公开(公告)日：2016-10-13

申请号：US15108279

申请日：2015-01-06

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Kyle Nadeau ,  Anthony J. Durkin ,  Bruce J. Tromberg

IPC: G06T7/00 ,  G06T7/40 ,  G06K9/46 ,  G01B11/25 ,  A61B1/06

CPC classification number: G06T7/0012 ,  A61B1/06 ,  G01B11/25 ,  G06K9/4604 ,  G06T7/42 ,  G06T7/50 ,  G06T7/521 ,  G06T2207/10068 ,  G06T2207/30004

Abstract: The present invention relates to methods and devices that may be used to extract spatial frequency information. In one embodiment, the invention provides an instrument configured to extract data using a two-dimensional (2D) Hilbert transform technique, and providing spatial frequency information from a sample. In another embodiment, the invention provides a spatial frequency domain imaging (SFDI) device adapted for demodulation using two or less imaging frames.

Abstract translation: 本发明涉及可用于提取空间频率信息的方法和装置。 在一个实施例中，本发明提供一种被配置为使用二维（Hilbert）变换技术提取数据并从样本提供空间频率信息的仪器。 在另一个实施例中，本发明提供适用于使用两个或更少成像帧进行解调的空间频域成像（SFDI）装置。

公开(公告)号：US20140213910A1

公开(公告)日：2014-07-31

申请号：US14163568

申请日：2014-01-24

Applicant: The Regents of the University of California

Inventor： Anthony J. Durkin ,  Amaan Mazhar ,  John Quan Minh Nguyen

IPC: A61B5/00 ,  G06T7/00

CPC classification number: G06T7/0016 ,  A61B5/0075 ,  A61B5/445 ,  G06T7/0012 ,  G06T2207/30088

Abstract: Frequent monitoring of early-stage burns is necessary for deciding optimal treatment and management. Superficial-partial thickness and deep-partial thickness burns, while visually similar, differ dramatically in terms of clinical treatment and are known to progress in severity over time. The disclosed method uses spatial frequency domain imaging (SFDI) far noninvasively mapping quantitative changes in chromophore and optical properties that may be an indicative of burn wound severity. A controlled protocol of graded burn severity is developed and applied to 17 rats. SFDI data is acquired at multiple near-infrared wavelengths over a course of 3 h. Burn severity is verified using hematoxylin and eosin histology. Changes in water concentration (edema), deoxygenated hemoglobin concentration, and optical scattering (tissue denaturation) are statistically significant measures, which are used to differentiate superficial partial-thickness burns from deep-partial thickness burns.

Abstract translation: 经常监测早期烧伤是决定最佳治疗和管理所必需的。 浅层部分厚度和深部分厚度烧伤在视觉上类似，在临床治疗方面有显着差异，并且已知随时间推移的严重程度。 所公开的方法使用空间频域成像（SFDI）远非侵入性地映射发色团和光学性质的定量变化，其可以是烧伤伤口严重性的指示。 开发了分级烧伤严重程度的控制方案，并应用于17只大鼠。 在3小时的过程中，以多个近红外波长采集SFDI数据。 使用苏木精和伊红组织学证实烧伤严重程度。 水分浓度（水肿），脱氧血红蛋白浓度和光学散射（组织变性）的变化是统计学显着的方法，用于区分表面部分厚度烧伤与深部部分厚度灼伤。