公开(公告)号：US20250152728A1

公开(公告)日：2025-05-15

申请号：US19027601

申请日：2025-01-17

Applicant: MedImmune, LLC ,  The Regents Of The University Of California

Inventor： Ronald James Christie ,  Changshou Gao ,  Andre Henri St. Amant ,  Javier Read de Alaniz

IPC: A61K47/68 ,  A61K47/69 ,  C07C271/22 ,  C07D207/46

Abstract: The present invention provides a bioconjugation method and compounds for use therein. The bioconjugation method comprises the step of conjugating a biological molecule containing a first unsaturated functional group with a payload comprising a second unsaturated functional group, wherein the first and second unsaturated functional groups are complementary to each other such that conjugation is a reaction of said functional groups via a Diels-Alder reaction which forms a cyclohexene ring.

公开(公告)号：US12150381B2

公开(公告)日：2024-11-19

申请号：US17826455

申请日：2022-05-27

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Julia Schneider ,  Michael L. Chabinyc ,  Hengbin Wang ,  Hidenori Nakayama ,  Kyle D. Clark ,  Javier Read de Alaniz

IPC: H10K85/60 ,  B82Y30/00 ,  C07D487/12 ,  C07D487/16 ,  H01B1/04 ,  H10K30/30 ,  H10K85/20

Abstract: Triazabicylodecene can effectively n-dope a variety of organic semiconductors, including PCBM, thus increasing in-plane conductivities. We synthesized a series of TBD-based n-dopants via an N-alkylation reaction and studied the effect of various alkyl chains on the physical and device properties of the dopants. Combining two TBD moieties on a long alky chain gave a solid dopant, 2TBD-C10, with high thermal stability above 250° C. PCBM films doped by 2TBD-C10 were the most tolerant to thermal annealing and reached in-plane conductivities of 6.5×10−2 S/cm. Furthermore, incorporating 2TBD-C10 doped PCBM as the electron transport layer (ETL) in methylammonium lead triiodide (MAPbI3) based photovoltaics led to a 23% increase in performance, from 11.8% to 14.5% PCE.

公开(公告)号：US11759526B2

公开(公告)日：2023-09-19

申请号：US16615582

申请日：2018-05-25

Applicant: MedImmune, LLC ,  The Regents Of The University Of California

Inventor： Ronald James Christie ,  Changshou Gao ,  Andre Henri St. Amant ,  Javier Read de Alaniz

IPC: A61K47/68 ,  A61K47/69 ,  C07C271/22 ,  C07D207/46

CPC classification number: A61K47/6811 ,  A61K47/6889 ,  A61K47/6923 ,  C07C271/22 ,  C07D207/46 ,  C07C2601/10 ,  C07C2602/50

Abstract: The present invention provides a bioconjugation method and compounds for use therein. The bioconjugation method comprises the step of conjugating a biological molecule containing a first unsaturated functional group with a payload comprising a second unsaturated functional group, wherein the first and second unsaturated functional groups are complementary to each other such that conjugation is a reaction of said functional groups via a Diels-Alder reaction which forms a cyclohexene ring.

公开(公告)号：US20190127345A1

公开(公告)日：2019-05-02

申请号：US16096063

申请日：2017-04-26

Applicant: The Regents of the University of California

Inventor： Javier Read de Alaniz ,  James Hemmer ,  Zachariah A. Page ,  Saemi Oh Poelma ,  Nicolas J. Treat ,  Sameh Helmy

IPC: C07D319/06 ,  C07D215/14 ,  C07D401/06 ,  C07D405/06 ,  C07D239/62 ,  C07D403/06 ,  C09K9/02

Abstract: Embodiments of the present disclosure describe a negative photochromatic material. Embodiments of the present disclosure further describe a method of tuning a negative photochromatic material comprising selecting an amine donor group, selecting an acceptor group, and contacting at least the selected amine donor group and the selected acceptor group to form a negative photochromatic material, wherein one or more of the selected amine donor group and the selected acceptor group tune at least an absorption range of the negative photochromatic material.

公开(公告)号：US11380852B2

公开(公告)日：2022-07-05

申请号：US16712206

申请日：2019-12-12

Applicant: The Regents of the University of California

Inventor： Julia Schneider ,  Michael L. Chabinyc ,  Hengbin Wang ,  Hidenori Nakayama ,  Kyle D. Clark ,  Javier Read de Alaniz

IPC: H01L51/00 ,  C07D487/16 ,  B82Y30/00 ,  C07D487/12 ,  H01L51/42 ,  H01B1/04

Abstract: Triazabicylodecene can effectively n-dope a variety of organic semiconductors, including PCBM, thus increasing in-plane conductivities. We synthesized a series of TBD-based n-dopants via an N-alkylation reaction and studied the effect of various alkyl chains on the physical and device properties of the dopants. Combining two TBD moieties on a long alky chain gave a solid dopant, 2TBD-C10, with high thermal stability above 250° C. PCBM films doped by 2TBD-C10 were the most tolerant to thermal annealing and reached in-plane conductivities of 6.5×10−2 S/cm. Furthermore, incorporating 2TBD-C10 doped PCBM as the electron transport layer (ETL) in methylammonium lead triiodide (MAPbI3) based photovoltaics led to a 23% increase in performance, from 11.8% to 14.5% PCE.

公开(公告)号：US20210284805A1

公开(公告)日：2021-09-16

申请号：US17191422

申请日：2021-03-03

Applicant: The Regents of the University of California

Inventor： Rachel A. Segalman ,  Craig J. Hawker ,  Raphaele Clement ,  Javier Read de Alaniz ,  Nicole Michenfelder-Schauser ,  Peter Richardson ,  Andrei Nikolaev ,  Caitlin Sample ,  Hengbin Wang

IPC: C08G77/32 ,  C08G77/28 ,  C08G77/20 ,  H01M10/0565

Abstract: A composition of matter useful in an electrolyte, comprising a polymer including: a repeat unit, the repeat unit including a backbone section; and a side chain attached to the backbone section, wherein the side chain includes a ligand moiety configured to ionically bond to a lithium ion. The polymer has a glass transition temperature (e.g., less than room temperature) wherein the polymer is in a solid state during operation of a lithium ion battery comprising an electrolyte including the polymer.

公开(公告)号：US20200206359A1

公开(公告)日：2020-07-02

申请号：US16615582

申请日：2018-05-25

Applicant: MedImmune, LLC ,  The Regents Of The University Of California

Inventor： Ronald James Christie ,  Changshou Gao ,  Andre Henri St. Amant ,  Javier Read de Alaniz

IPC: A61K47/68 ,  C07C271/22 ,  C07D207/46 ,  A61K47/69

Abstract: The present invention provides a bioconjugation method and compounds for use therein. The bioconjugation method comprises the step of conjugating a biological molecule containing a first unsaturated functional group with a payload comprising a second unsaturated functional group, wherein the first and second unsaturated functional groups are complementary to each other such that conjugation is a reaction of said functional groups via a Diels-Alder reaction which forms a cyclohexene ring.

公开(公告)号：US20230321267A1

公开(公告)日：2023-10-12

申请号：US18191372

申请日：2023-03-28

Applicant: MedImmune, LLC ,  The Regents Of The University Of California

Inventor： Ronald James Christie ,  Changshou Gao ,  Andre Henri St. Amant ,  Javier Read de Alaniz

IPC: A61K47/68 ,  A61K47/69 ,  C07C271/22 ,  C07D207/46

CPC classification number: A61K47/6811 ,  A61K47/6889 ,  A61K47/6923 ,  C07C271/22 ,  C07D207/46 ,  C07C2601/10 ,  C07C2602/50

Abstract: The present invention provides a bioconjugation method and compounds for use therein. The bioconjugation method comprises the step of conjugating a biological molecule containing a first unsaturated functional group with a payload comprising a second unsaturated functional group, wherein the first and second unsaturated functional groups are complementary to each other such that conjugation is a reaction of said functional groups via a Diels-Alder reaction which forms a cyclohexene ring.

公开(公告)号：US20220293866A1

公开(公告)日：2022-09-15

申请号：US17826455

申请日：2022-05-27

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Julia Schneider ,  Michael L. Chabinyc ,  Hengbin Wang ,  Hidenori Nakayama ,  Kyle D. Clark ,  Javier Read de Alaniz

IPC: H01L51/00 ,  C07D487/16 ,  B82Y30/00 ,  C07D487/12

Abstract: Triazabicylodecene can effectively n-dope a variety of organic semiconductors, including PCBM, thus increasing in-plane conductivities. We synthesized a series of TBD-based n-dopants via an N-alkylation reaction and studied the effect of various alkyl chains on the physical and device properties of the dopants. Combining two TBD moieties on a long alky chain gave a solid dopant, 2TBD-C10, with high thermal stability above 250° C. PCBM films doped by 2TBD-C10 were the most tolerant to thermal annealing and reached in-plane conductivities of 6.5×10−2 S/cm. Furthermore, incorporating 2TBD-C10 doped PCBM as the electron transport layer (ETL) in methylammonium lead triiodide (MAPbI3) based photovoltaics led to a 23% increase in performance, from 11.8% to 14.5% PCE.

公开(公告)号：US20200056999A1

公开(公告)日：2020-02-20

申请号：US16343907

申请日：2017-10-19

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Javier Read de Alaniz ,  Craig Hawker ,  James Hemmer ,  Yvonne Diaz ,  Abigail S. Knight ,  Zachariah A. Page ,  Tal Margalith

IPC: G01N21/78 ,  G01N31/22

Abstract: Embodiments of the present disclosure describe a colorimetric sensor comprising a substrate including an activated furan and configured to undergo a color change upon detecting an amine. Embodiments of the present disclosure describe a method of using a colorimetric sensor comprising applying an activated furan to a substrate, providing the substrate to a medium, and detecting an amine in the medium via change in color of the substrate. Embodiments of the present disclosure further describe a method of detecting an amine comprising contacting furfural with a cyclic acceptor group to form an activated furan for detecting amines, and contacting the activated furan with an amine to produce a colored donor-acceptor Stenhouse adduct.