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公开(公告)号：US11666660B2
公开(公告)日：2023-06-06
申请号：US17134828
申请日：2020-12-28
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Michael Demetriou , Raymond Wenhou Zhou
CPC classification number: A61K47/6849 , A61K38/168 , A61P35/00 , C07K16/2809 , C07K16/2851 , C07K2317/24 , C07K2317/31 , C07K2317/622 , C07K2319/33
Abstract: The present invention relates to compositions and methods for treating cancer. The invention makes use of peptides, nucleic acids encoding such peptides, and cells expressing such peptides, where the peptide comprises a tumor-associated carbohydrate antigen (TACA)-binding domain.
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公开(公告)号：US10925972B2
公开(公告)日：2021-02-23
申请号：US15571101
申请日：2016-04-29
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Michael Demetriou , Raymond Wenhou Zhou
Abstract: The present invention relates to compositions and methods for treating cancer. The invention makes use of peptides, nucleic acids encoding such peptides, and cells expressing such peptides, where the peptide comprises a tumor-associated carbohydrate antigen (TACA)-binding domain.
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公开(公告)号：US20240415858A1
公开(公告)日：2024-12-19
申请号：US18694720
申请日：2022-09-23
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Michael Demetriou , Michael Sy , Alexander Brandt
IPC: A61K31/7008 , A61K9/00 , A61P25/00
Abstract: The present invention features compositions and methods for the repair of myelin and/or treatment of demyelinating diseases. The demyelinating disease may be multiple sclerosis (MS), optic neuritis, myelin oligodendrocyte glycoprotein antibody associated disease, neuromyelitis optica spectrum disorder, transverse myelitis, or acute disseminated encephalomyelitis. The compositions may include N-acetylglucosamine (GIcNAc), GlcNAc-6-acetate, or a combination thereof. The method may involve administering the compositions to a subject in need.
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4.发明授权公开(公告)号：US09775859B2
公开(公告)日：2017-10-03
申请号：US14158221
申请日：2014-01-17
Inventor： Michael Demetriou , James Dennis , Ken Siu-Kwong Lau
IPC: A61K31/00 , A61K31/7072 , A01K67/027 , A61K31/593 , A61K31/70 , A61K45/06 , G01N33/564 , A61K31/7008
CPC classification number: A61K31/7072 , A01K67/0275 , A01K2227/105 , A01K2267/0318 , A61K31/593 , A61K31/70 , A61K31/7008 , A61K45/06 , G01N33/564 , G01N2400/10 , G01N2800/285 , A61K2300/00
Abstract: Contemplated compositions and methods are directed to prevent and/or treat various autoimmune diseases that are typically associated with glycan dysregulation, and especially autoimmune demyelinating diseases. Further especially contemplated aspects include animal models and systems for screening compounds to treat and/or prevent such diseases.
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Patent Agency Ranking
公开(公告)号：US10881744B2
公开(公告)日：2021-01-05
申请号：US15571101
申请日：2016-04-29
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Michael Demetriou , Raymond Wenhou Zhou
Abstract: The present invention relates to compositions and methods for treating cancer. The invention makes use of peptides, nucleic acids encoding such peptides, and cells expressing such peptides, where the peptide comprises a tumor-associated carbohydrate antigen (TACA)-binding domain.
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公开(公告)号：US20180003717A1
公开(公告)日：2018-01-04
申请号：US15547496
申请日：2016-01-29
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , CHARITE-UNIVERSITATSMEDIZIN BERLIN , MT. SINAI HOSPITAL
Inventor： Michael Demetriou , Alexander Brandt , Paul Friedmann , James Dennis
IPC: G01N33/66
CPC classification number: G01N33/66 , G01N2400/00 , G01N2800/285 , G01N2800/52
Abstract: The invention provides the art with a powerful diagnostic method of distinguishing relapse-remitting MS subjects from progressive MS subjects, based on the measurement of serum concentrations of N-acetylglucosamine (GlcNAc,), for the first time enabling rapid diagnosis of the progressive form of MS. GlcNAc serum concentration can also be used to assess neurodegenerative status and MS progression in subjects suffering from MS or other neurological conditions. The methods of the invention also allow for the identification of new therapeutics for MS and other neurological conditions and also enables the personalized efficacy assessment of a potential therapy for an MS subject.
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公开(公告)号：US11103520B2
公开(公告)日：2021-08-31
申请号：US15305609
申请日：2015-04-23
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , James Dennis
Inventor： Michael Demetriou , James Dennis , Ani Oganesyan
IPC: A61K31/7008 , A61K31/726 , A61K45/06 , A23L33/10
Abstract: The present invention includes a novel method of treating or preventing a disease or disorder associated with low levels of branched N-glycans in a subject in need thereof, the method comprising administering to the subject an effective amount of a compound of the invention. In one embodiment, the subject is further administered at least one additional therapeutic agent.
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公开(公告)号：US20170042919A1
公开(公告)日：2017-02-16
申请号：US15305609
申请日：2015-04-23
Applicant: James Dennis , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Michael Demetriou , James Dennis , Ani Oganesyan
IPC: A61K31/7008 , A61K45/06
CPC classification number: A61K31/7008 , A23L33/10 , A61K31/726 , A61K45/06 , Y02A50/401 , Y02A50/414 , A61K2300/00
Abstract: The present invention includes a novel method of treating or preventing a disease or disorder associated with low levels of branched N-glycans in a subject in need thereof, the method comprising administering to the subject an effective amount of a compound of the invention. In one embodiment, the subject is further administered at least one additional therapeutic agent.
Abstract translation: 本发明包括治疗或预防与有需要的受试者中低水平的支链N-聚糖相关的疾病或病症的新方法，所述方法包括给予受试者有效量的本发明化合物。 在一个实施方案中，受试者进一步施用至少一种另外的治疗剂。
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9.发明申请METHODS AND COMPOSITIONS FOR PREVENTING AND TREATING A DISEASE RELATED TO GLYCAN DYSREGULATION 有权预防和治疗与糖尿病相关的疾病的方法和组合物公开(公告)号：US20140228313A1
公开(公告)日：2014-08-14
申请号：US14158221
申请日：2014-01-17
Inventor： Michael Demetriou , James Dennis , Ken Siu-Kwong Lau
IPC: A61K31/7072 , A61K31/593 , A61K31/7008
CPC classification number: A61K31/7072 , A01K67/0275 , A01K2227/105 , A01K2267/0318 , A61K31/593 , A61K31/70 , A61K31/7008 , A61K45/06 , G01N33/564 , G01N2400/10 , G01N2800/285 , A61K2300/00
Abstract: Contemplated compositions and methods are directed to prevent and/or treat various autoimmune diseases that are typically associated with glycan dysregulation, and especially autoimmune demyelinating diseases. Further especially contemplated aspects include animal models and systems for screening compounds to treat and/or prevent such diseases.
Abstract translation: 考虑的组合物和方法旨在预防和/或治疗通常与聚糖失调调节，特别是自身免疫性脱髓鞘疾病相关的各种自身免疫性疾病。 进一步特别考虑的方面包括用于筛选化合物以治疗和/或预防这些疾病的动物模型和系统。
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