公开(公告)号：US20170358419A1

公开(公告)日：2017-12-14

申请号：US15665659

申请日：2017-08-01

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Neville C. Luhmann, JR. ,  Gordon Soekland ,  Diana Gamzina ,  Na Li

IPC: H01J1/146 ,  C04B35/50 ,  C01G41/00 ,  C04B35/626 ,  C04B35/64 ,  C04B35/624 ,  H01J9/04

Abstract: Methods for fabricating refractory metal scandate nanocomposite powders with homogeneous microstructured refractory metal grains and a uniform nanosized dispersion of scandia are provided. The powders prepared by the sol-gel methods have a spherical morphology, a narrow distribution of particle sizes and a very uniform dispersion of nanosized scandia particles joined to the tungsten grains. The powder particle sizes can range from nanometers to micrometers. The powders can be pressed into porous cathode structures that can be impregnated with emissive materials to produce high current density and long life cathodes for high-power terahertz vacuum electron devices. The sol-gel fabrication methods allow control over the materials, particle size, particle composition and pore size and distribution of the cathode structure by manipulation of the process parameters.

公开(公告)号：US20150004713A1

公开(公告)日：2015-01-01

申请号：US14296034

申请日：2014-06-04

Applicant: The Regents of the University of California

Inventor： Na Li ,  Fang Wei ,  Huaping Li ,  Guillermo C. Bazan

IPC: G01N31/22 ,  G01N21/78 ,  G01N21/82

CPC classification number: G01N31/22 ,  B82Y15/00 ,  G01N21/554 ,  G01N21/78 ,  G01N21/82 ,  Y10S977/773 ,  Y10S977/81 ,  Y10S977/921 ,  Y10T436/147777

Abstract: Methods and materials for the detection of melamine in test samples such as foodstuffs are described. Embodiments of the invention comprise combining a test sample suspected of containing melamine with a particle that produces a colorimetric and/or turbidimetric signal that is dependent upon the concentration of melamine in the test sample. In certain embodiments of the invention, the particles and test sample are combined together with a chemical compound selected to induce the aggregation melamine in a manner that amplifies the colorimetric and/or turbidimetric signal of the assay. In some embodiments of the invention, the aggregation inducing agent is not physically coupled to the particles used in the assays. In other embodiments of the invention, the aggregation inducing agent is physically coupled to the particles used in these assays.

Abstract translation: 描述了测试样品如食品中检测三聚氰胺的方法和材料。 本发明的实施方案包括将怀疑含有三聚氰胺的测试样品与产生取决于测试样品中三聚氰胺浓度的比色和/或比浊信号的颗粒组合。 在本发明的某些实施方案中，颗粒和测试样品与选择用于以扩增测定的比色和/或比浊信号的方式诱导聚集三聚氰胺的化学化合物组合在一起。 在本发明的一些实施方案中，聚集诱导剂不与用于测定中的颗粒物理偶联。 在本发明的其它实施方案中，聚集诱导剂与这些测定中使用的颗粒物理耦合。

公开(公告)号：US09194851B2

公开(公告)日：2015-11-24

申请号：US14296034

申请日：2014-06-04

Applicant: The Regents of the University of California

Inventor： Na Li ,  Fang Wei

IPC: G01N31/22 ,  G01N21/552 ,  G01N21/78 ,  G01N21/82 ,  G01N21/00 ,  B82Y15/00

CPC classification number: G01N31/22 ,  B82Y15/00 ,  G01N21/554 ,  G01N21/78 ,  G01N21/82 ,  Y10S977/773 ,  Y10S977/81 ,  Y10S977/921 ,  Y10T436/147777

Abstract: Methods and materials for the detection of melamine in test samples such as foodstuffs are described. Embodiments of the invention comprise combining a test sample suspected of containing melamine with a particle that produces a colorimetric and/or turbidimetric signal that is dependent upon the concentration of melamine in the test sample. In certain embodiments of the invention, the particles and test sample are combined together with a chemical compound selected to induce the aggregation melamine in a manner that amplifies the colorimetric and/or turbidimetric signal of the assay. In some embodiments of the invention, the aggregation inducing agent is not physically coupled to the particles used in the assays. In other embodiments of the invention, the aggregation inducing agent is physically coupled to the particles used in these assays.

Abstract translation: 描述了测试样品如食品中检测三聚氰胺的方法和材料。 本发明的实施方案包括将怀疑含有三聚氰胺的测试样品与产生取决于测试样品中三聚氰胺浓度的比色和/或比浊信号的颗粒组合。 在本发明的某些实施方案中，颗粒和测试样品与选择用于以扩增测定的比色和/或比浊信号的方式诱导聚集三聚氰胺的化学化合物组合在一起。 在本发明的一些实施方案中，聚集诱导剂不与用于测定中的颗粒物理偶联。 在本发明的其它实施方案中，聚集诱导剂与这些测定中使用的颗粒物理耦合。

公开(公告)号：US20170074849A1

公开(公告)日：2017-03-16

申请号：US15123609

申请日：2015-03-05

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  THE UNIVERSITY OF MIAMI

Inventor： Fang Wei ,  Na Li

IPC: G01N33/04 ,  G01N21/78

CPC classification number: G01N33/04 ,  B82Y15/00 ,  G01N21/78 ,  G01N31/00 ,  G01N31/22 ,  G01N33/48707 ,  G01N2021/757 ,  G01N2021/7759 ,  G01N2021/7766

Abstract: Described here is a test strip for detection of melamine, comprising: a support configured for capillary flow of a fluid sample from a first end of the support to a second end of the support that is downstream from the first end; a conjugation pad disposed adjacent to the first end of the support and including nanoparticles configured for suspension in the sample flowing past the conjugation pad, the nanoparticles configured to produce a colorimetric effect when exposed to melamine; and a test portion downstream of the conjugation pad and including a molecular recognition agent immobilized on the support and having an affinity for melamine.

Abstract translation: 这里描述的是用于检测三聚氰胺的测试条，包括：支撑件，其构造成用于将流体样品从支撑件的第一端毛细管流到支撑件的第二端，该第二端在第一端的下游; 接合垫，其布置成邻近所述支撑体的第一端并且包括被配置为悬浮在流过所述共轭垫的样品中的纳米颗粒，所述纳米颗粒构造成当暴露于三聚氰胺时产生比色效应; 和缀合垫下游的测试部分，并且包括固定在载体上并对三聚氰胺具有亲和力的分子识别剂。

公开(公告)号：US10714292B2

公开(公告)日：2020-07-14

申请号：US15665659

申请日：2017-08-01

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Neville C. Luhmann, Jr. ,  Gordon Soekland ,  Diana Gamzina ,  Na Li

IPC: H01J9/04 ,  C04B35/624 ,  C04B35/626 ,  C04B35/64 ,  C04B35/495 ,  C04B35/50 ,  H01J1/146 ,  H01J1/142 ,  C01G41/00

Abstract: Methods for fabricating refractory metal scandate nanocomposite powders with homogeneous microstructured refractory metal grains and a uniform nanosized dispersion of scandia are provided. The powders prepared by the sol-gel methods have a spherical morphology, a narrow distribution of particle sizes and a very uniform dispersion of nanosized scandia particles joined to the tungsten grains. The powder particle sizes can range from nanometers to micrometers. The powders can be pressed into porous cathode structures that can be impregnated with emissive materials to produce high current density and long life cathodes for high-power terahertz vacuum electron devices. The sol-gel fabrication methods allow control over the materials, particle size, particle composition and pore size and distribution of the cathode structure by manipulation of the process parameters.