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公开(公告)号：US20180230460A1
公开(公告)日：2018-08-16
申请号：US15948793
申请日：2018-04-09
发明人： Ryan T. GILL , Andrew GARST , Tanya Elizabeth Warnecke LIPSCOMB , Marcelo Colika BASSALO , Ramsey Ibrahim ZEITOUN
CPC分类号： C12N15/1065 , C12N15/102 , C12N15/1079 , C12N15/1082 , C12N15/11 , C12N2310/20 , C12Q2563/179
摘要： Provided herein are methods and composition for trackable genetic variant libraries. Further provided herein are methods and compositions for recursive engineering. Further provided herein are methods and compositions for multiplex engineering. Further provided herein are methods and compositions for enriching for editing and trackable engineered sequences and cells using nucleic acid-guided nucleases.
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公开(公告)号：US20200157575A1
公开(公告)日：2020-05-21
申请号：US16773712
申请日：2020-01-27
发明人： Andrew GARST , Ryan T. GILL
摘要： Described herein are methods and vectors for rational, multiplexed manipulation of chromosomes within open reading frames (e.g., in protein libraries) or any segment of a chromosome in a cell or population of cells, in which various CRISPR systems are used.
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公开(公告)号：US20180230461A1
公开(公告)日：2018-08-16
申请号：US15948798
申请日：2018-04-09
发明人： Ryan T. GILL , Andrew GARST , Tanya Elizabeth Warnecke LIPSCOMB , Marcelo Colika BASSALO , Ramsey Ibrahim ZEITOUN
CPC分类号： C12N15/1065 , C12N15/102 , C12N15/1079 , C12N15/1082 , C12N15/11 , C12N2310/20 , C12Q2563/179
摘要： Provided herein are methods and composition for trackable genetic variant libraries. Further provided herein are methods and compositions for recursive engineering. Further provided herein are methods and compositions for multiplex engineering. Further provided herein are methods and compositions for enriching for editing and trackable engineered sequences and cells using nucleic acid-guided nucleases.
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公开(公告)号：US20190390227A1
公开(公告)日：2019-12-26
申请号：US16550092
申请日：2019-08-23
发明人： Andrew GARST , Ryan T. GILL
摘要： Described herein are methods and vectors for rational, multiplexed manipulation of chromosomes within open reading frames (e.g., in protein libraries) or any segment of a chromosome in a cell or population of cells, in which various CRISPR systems are used.
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公开(公告)号：US20200157574A1
公开(公告)日：2020-05-21
申请号：US16773618
申请日：2020-01-27
发明人： Andrew GARST , Ryan T. GILL
摘要： Described herein are methods and vectors for rational, multiplexed manipulation of chromosomes within open reading frames (e.g., in protein libraries) or any segment of a chromosome in a cell or population of cells, in which various CRISPR systems are used.
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公开(公告)号：US20180230492A1
公开(公告)日：2018-08-16
申请号：US15948785
申请日：2018-04-09
发明人： Ryan T. GILL , Andrew GARST
CPC分类号： C12N15/902 , C12N9/22 , C12N15/102 , C12N15/1024 , C12N15/1082 , C12N15/1093 , C12N15/11 , C12N15/111 , C12N2310/10 , C12N2310/20 , C12N2320/11 , C12N2320/12 , C12N2330/31 , C40B40/08
摘要： Described herein are methods and vectors for rational, multiplexed manipulation of chromosomes within open reading frames (e.g., in protein libraries) or any segment of a chromosome in a cell or population of cells, in which various CRISPR systems are used.
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公开(公告)号：US20170369870A1
公开(公告)日：2017-12-28
申请号：US15632222
申请日：2017-06-23
发明人： Ryan T. GILL , Andrew GARST , Tanya Elizabeth Warnecke LIPSCOMB , Marcelo Colika BASSALO , Ramsey Ibrahim ZEITOUN
IPC分类号： C12N15/10 , C12N15/11 , C12N2310/20
CPC分类号： C12N15/1065 , C12N15/102 , C12N15/1079 , C12N15/1082 , C12N15/11 , C12N2310/20 , C12Q2563/179
摘要： Provided herein are methods and composition for trackable genetic variant libraries. Further provided herein are methods and compositions for recursive engineering. Further provided herein are methods and compositions for multiplex engineering. Further provided herein are methods and compositions for enriching for editing and trackable engineered sequences and cells using nucleic acid-guided nucleases.
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公开(公告)号：US20170009283A1
公开(公告)日：2017-01-12
申请号：US15116300
申请日：2015-02-09
发明人： Ryan T. GILL , Ramsey ZEITOUN , Andrew GARST
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6853 , C12P19/34 , C12Y207/07007 , C12Q2525/155 , C12Q2525/161 , C12Q2537/101 , C12Q2537/143
摘要： The invention provides compositions and methods for rapid assembly of one or more assembled polynucleotides from a plurality of component polynucleotides, as well as methods of designing polynucleotide primer and linker sets useful in the assembly methods of the invention.
摘要翻译： 本发明提供了用于从多个组分多核苷酸快速组装一种或多种组装的多核苷酸的组合物和方法，以及设计用于本发明的组装方法的多核苷酸引物和连接体组的方法。
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公开(公告)号：US20190376087A1
公开(公告)日：2019-12-12
申请号：US16551517
申请日：2019-08-26
发明人： Andrew GARST , Ryan T. GILL
摘要： Described herein are methods and vectors for rational, multiplexed manipulation of chromosomes within open reading frames (e.g., in protein libraries) or any segment of a chromosome in a cell or population of cells, in which various CRISPR systems are used.
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公开(公告)号：US20180371499A1
公开(公告)日：2018-12-27
申请号：US16056310
申请日：2018-08-06
发明人： Ryan T. GILL , Andrew GARST
CPC分类号： C12N15/902 , C12N9/22 , C12N15/102 , C12N15/1024 , C12N15/1082 , C12N15/1093 , C12N15/11 , C12N15/111 , C12N2310/10 , C12N2310/20 , C12N2320/11 , C12N2320/12 , C12N2330/31 , C40B40/08
摘要： Described herein are methods and vectors for rational, multiplexed manipulation of chromosomes within open reading frames (e.g., in protein libraries) or any segment of a chromosome in a cell or population of cells, in which various CRISPR systems are used.
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