公开(公告)号：US10508116B2

公开(公告)日：2019-12-17

申请号：US15726419

申请日：2017-10-06

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Christopher N. Bowman ,  Weixian Xi ,  Sankha Pattanayak

IPC: C07D473/34 ,  C08G75/045 ,  C12N15/113 ,  C07D239/47 ,  C07D473/18 ,  C07D239/54 ,  C12Q1/6876 ,  C08G75/00

Abstract: Disclosed herein are Click Nucleic Acid Polymers (CNA-polymers) that comprise repeating dimer, trimer and tetramer units. The disclosed polymers can be used for antisense applications, for example, in treatment of “trinucleotide repeat disorders, i.e., Huntington's Disease and the like.

公开(公告)号：US20180100036A1

公开(公告)日：2018-04-12

申请号：US15726419

申请日：2017-10-06

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Christopher N. Bowman ,  Weixian Xi ,  Sankha Pattanayak

IPC: C08G75/045 ,  C12N15/113

CPC classification number: C07D473/34 ,  C07D239/47 ,  C07D239/54 ,  C07D473/18 ,  C08G75/00 ,  C08G75/045 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/318 ,  C12Q1/6876

Abstract: Disclosed herein are Click Nucleic Acid Polymers (CNA-polymers) that comprise repeating dimer, trimer and tetramer units. The disclosed polymers can be used for antisense applications, for example, in treatment of “trinucleotide repeat disorders, i.e., Huntington's Disease and the like.

公开(公告)号：US10017510B2

公开(公告)日：2018-07-10

申请号：US15116978

申请日：2015-02-06

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Christopher N. Bowman ,  Christopher J. Kloxin ,  Weixian Xi ,  Tao Gong ,  Sankha Pattanayak

IPC: C07D473/34 ,  C07D239/47 ,  C07D239/54 ,  C07D473/18 ,  C12Q1/68 ,  C12Q1/6876 ,  C12N15/10

CPC classification number: C07D473/34 ,  C07D239/47 ,  C07D239/54 ,  C07D473/18 ,  C12N15/1048 ,  C12N15/1093 ,  C12Q1/68 ,  C12Q1/6876

Abstract: Click thiol-X monomers and polymers containing such monomers are disclosed. The clickable sequence controllable monomers include an optionally protected thiol moiety; an optionally protected Michael acceptor moiety; a primary functional side chain and one ore more secondary functional side chains. A clickable sequence controllable monomer, can have the structure: wherein independently Y and Z are atoms having a valence electrons of 3 or more; n is a integer from 0-10; m is a integer from 0-10; x is a integer from 0-10; PFS is a functional group SFSi; SFS2; and SFS3 are independently a combination of hydrogen, hydroxyl, aromatic, amine, carboxyl, and carbonyls, optionally substituted to form hydrophilic, hydrophobic, amphiphilic, or charged (positive or negative or both) side chains; T is an optionally protected thiol; and TCA is an optionally protected thiol-click acceptor. Methods of using such polymers are also disclosed.