公开(公告)号：US09701792B2

公开(公告)日：2017-07-11

申请号：US14663015

申请日：2015-03-19

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Christopher N. Bowman ,  Christopher J. Kloxin ,  Jeffrey Stansbury ,  Tao Gong ,  Matthew McBride

IPC: C08F2/46 ,  C08F2/50 ,  C08G61/04 ,  C08G73/08 ,  A61K6/087 ,  A61K6/083 ,  C08L79/06

CPC classification number: C08G73/08 ,  A61K6/083 ,  A61K6/087 ,  C08L79/06 ,  C08L33/10

Abstract: The present invention includes compositions comprising an alkyne-based substrate, an azide-based substrate, optionally a Cu(II) salt and optionally a photoinducible reducing agent. The present invention further includes a method of preparing composite materials that are suitable for use as dental implants using the compositions of the invention.

公开(公告)号：US10017510B2

公开(公告)日：2018-07-10

申请号：US15116978

申请日：2015-02-06

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Christopher N. Bowman ,  Christopher J. Kloxin ,  Weixian Xi ,  Tao Gong ,  Sankha Pattanayak

IPC: C07D473/34 ,  C07D239/47 ,  C07D239/54 ,  C07D473/18 ,  C12Q1/68 ,  C12Q1/6876 ,  C12N15/10

CPC classification number: C07D473/34 ,  C07D239/47 ,  C07D239/54 ,  C07D473/18 ,  C12N15/1048 ,  C12N15/1093 ,  C12Q1/68 ,  C12Q1/6876

Abstract: Click thiol-X monomers and polymers containing such monomers are disclosed. The clickable sequence controllable monomers include an optionally protected thiol moiety; an optionally protected Michael acceptor moiety; a primary functional side chain and one ore more secondary functional side chains. A clickable sequence controllable monomer, can have the structure: wherein independently Y and Z are atoms having a valence electrons of 3 or more; n is a integer from 0-10; m is a integer from 0-10; x is a integer from 0-10; PFS is a functional group SFSi; SFS2; and SFS3 are independently a combination of hydrogen, hydroxyl, aromatic, amine, carboxyl, and carbonyls, optionally substituted to form hydrophilic, hydrophobic, amphiphilic, or charged (positive or negative or both) side chains; T is an optionally protected thiol; and TCA is an optionally protected thiol-click acceptor. Methods of using such polymers are also disclosed.

公开(公告)号：US09700492B2

公开(公告)日：2017-07-11

申请号：US14640809

申请日：2015-03-06

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Christopher N. Bowman ,  Weixian Xi ,  Shunsuke Chatani ,  Tao Gong ,  Devatha P. Nair ,  Maciej Podgorski

IPC: C08F2/46 ,  C08F2/50 ,  C08G61/04 ,  A61K6/087 ,  C08G18/73 ,  C08G18/67 ,  C08G18/38 ,  A61K6/00

CPC classification number: A61K6/087 ,  A61K6/0079 ,  C08G18/3876 ,  C08G18/677 ,  C08G18/73

Abstract: The invention includes a composition comprising a vinyl sulfone monomer, a thiol monomer, and optionally an isocyanate monomer. The invention further includes a composition comprising a composition comprising the tetra(2-mercapto)silane (SiTSH) monomer and at least one selected from the group consisting of (a) a Michael acceptor, optionally an isocyanate monomer, and optionally at least one catalyst selected from the group consisting of a base, nucleophile, photolabile base, photolabile nucleophile, and mixtures thereof; (b) an ene monomer, and optionally a polymerization photoinitiator. In certain embodiments, once the composition is polymerized, the polymerized system is suitable for use as a dental composite system. In other embodiments, the polymerized system is stable to acidic and basic conditions. In yet other embodiments, the polymerized system forms microparticles. The invention further includes a method of generating a dental polymeric material.