公开(公告)号：US09700492B2

公开(公告)日：2017-07-11

申请号：US14640809

申请日：2015-03-06

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Christopher N. Bowman ,  Weixian Xi ,  Shunsuke Chatani ,  Tao Gong ,  Devatha P. Nair ,  Maciej Podgorski

IPC: C08F2/46 ,  C08F2/50 ,  C08G61/04 ,  A61K6/087 ,  C08G18/73 ,  C08G18/67 ,  C08G18/38 ,  A61K6/00

CPC classification number: A61K6/087 ,  A61K6/0079 ,  C08G18/3876 ,  C08G18/677 ,  C08G18/73

Abstract: The invention includes a composition comprising a vinyl sulfone monomer, a thiol monomer, and optionally an isocyanate monomer. The invention further includes a composition comprising a composition comprising the tetra(2-mercapto)silane (SiTSH) monomer and at least one selected from the group consisting of (a) a Michael acceptor, optionally an isocyanate monomer, and optionally at least one catalyst selected from the group consisting of a base, nucleophile, photolabile base, photolabile nucleophile, and mixtures thereof; (b) an ene monomer, and optionally a polymerization photoinitiator. In certain embodiments, once the composition is polymerized, the polymerized system is suitable for use as a dental composite system. In other embodiments, the polymerized system is stable to acidic and basic conditions. In yet other embodiments, the polymerized system forms microparticles. The invention further includes a method of generating a dental polymeric material.

公开(公告)号：US10017510B2

公开(公告)日：2018-07-10

申请号：US15116978

申请日：2015-02-06

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Christopher N. Bowman ,  Christopher J. Kloxin ,  Weixian Xi ,  Tao Gong ,  Sankha Pattanayak

IPC: C07D473/34 ,  C07D239/47 ,  C07D239/54 ,  C07D473/18 ,  C12Q1/68 ,  C12Q1/6876 ,  C12N15/10

CPC classification number: C07D473/34 ,  C07D239/47 ,  C07D239/54 ,  C07D473/18 ,  C12N15/1048 ,  C12N15/1093 ,  C12Q1/68 ,  C12Q1/6876

Abstract: Click thiol-X monomers and polymers containing such monomers are disclosed. The clickable sequence controllable monomers include an optionally protected thiol moiety; an optionally protected Michael acceptor moiety; a primary functional side chain and one ore more secondary functional side chains. A clickable sequence controllable monomer, can have the structure: wherein independently Y and Z are atoms having a valence electrons of 3 or more; n is a integer from 0-10; m is a integer from 0-10; x is a integer from 0-10; PFS is a functional group SFSi; SFS2; and SFS3 are independently a combination of hydrogen, hydroxyl, aromatic, amine, carboxyl, and carbonyls, optionally substituted to form hydrophilic, hydrophobic, amphiphilic, or charged (positive or negative or both) side chains; T is an optionally protected thiol; and TCA is an optionally protected thiol-click acceptor. Methods of using such polymers are also disclosed.

公开(公告)号：US10508116B2

公开(公告)日：2019-12-17

申请号：US15726419

申请日：2017-10-06

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Christopher N. Bowman ,  Weixian Xi ,  Sankha Pattanayak

IPC: C07D473/34 ,  C08G75/045 ,  C12N15/113 ,  C07D239/47 ,  C07D473/18 ,  C07D239/54 ,  C12Q1/6876 ,  C08G75/00

Abstract: Disclosed herein are Click Nucleic Acid Polymers (CNA-polymers) that comprise repeating dimer, trimer and tetramer units. The disclosed polymers can be used for antisense applications, for example, in treatment of “trinucleotide repeat disorders, i.e., Huntington's Disease and the like.

公开(公告)号：US20150057187A1

公开(公告)日：2015-02-26

申请号：US14388748

申请日：2013-03-12

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Christopher N. Bowman ,  Christopher J. Kloxin ,  Weixian Xi

IPC: C12Q1/68

CPC classification number: C07D473/34 ,  C07D239/47 ,  C07D239/54 ,  C07D473/18 ,  C12Q1/6876 ,  C12Q2600/156

Abstract: Click nucleic acid monomers and polymers containing such monomers are disclosed. The click nucleic acid monomers include an optionally protected thiol moiety, an optionally protected thiol-click acceptor moiety, and an optionally protected nucleobase (NB), which in some examples is an A, G, T, U, or C nucleobase. In some examples, the click nucleic acid monomer includes a N-vinyl thiol acetamide (VTA) backbone. In other examples the click nucleic acid monomer includes a N-vinyl thiol ethylamine (VTE) backbone. Methods of using such polymers, for example in place of naturally occurring nucleic acid polymer applications, such as DNA or RNA, and synthetic nucleic acid polymer applications, such as PNA or morpholino nucleic acids, are also disclosed.

Abstract translation: 公开了点击核酸单体和含有这些单体的聚合物。 点击的核酸单体包括任选保护的硫醇部分，任选保护的硫醇 - 键受体部分和任选保护的核碱基（NB），其在一些实例中为A，G，T，U或C核碱基。 在一些实例中，点击核酸单体包括N-乙烯基硫醇乙酰胺（VTA）主链。 在其它实例中，点击式核酸单体包括N-乙烯基硫醇乙胺（VTE）主链。 还公开了使用这种聚合物的方法，例如代替天然存在的核酸聚合物应用，例如DNA或RNA，以及合成的核酸聚合物应用，例如PNA或吗啉代核酸。

公开(公告)号：US20180100036A1

公开(公告)日：2018-04-12

申请号：US15726419

申请日：2017-10-06

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Christopher N. Bowman ,  Weixian Xi ,  Sankha Pattanayak

IPC: C08G75/045 ,  C12N15/113

CPC classification number: C07D473/34 ,  C07D239/47 ,  C07D239/54 ,  C07D473/18 ,  C08G75/00 ,  C08G75/045 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/318 ,  C12Q1/6876

Abstract: Disclosed herein are Click Nucleic Acid Polymers (CNA-polymers) that comprise repeating dimer, trimer and tetramer units. The disclosed polymers can be used for antisense applications, for example, in treatment of “trinucleotide repeat disorders, i.e., Huntington's Disease and the like.

公开(公告)号：US09879012B2

公开(公告)日：2018-01-30

申请号：US14388748

申请日：2013-03-12

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Christopher N. Bowman ,  Christopher J. Kloxin ,  Weixian Xi

IPC: C07D473/34 ,  C07D473/18 ,  C07D239/47 ,  C07D239/54 ,  C12Q1/68

CPC classification number: C07D473/34 ,  C07D239/47 ,  C07D239/54 ,  C07D473/18 ,  C12Q1/6876 ,  C12Q2600/156

Abstract: Click nucleic acid monomers and polymers containing such monomers are disclosed. The click nucleic acid monomers include an optionally protected thiol moiety, an optionally protected thiol-click acceptor moiety, and an optionally protected nucleobase (NB), which in some examples is an A, G, T, U, or C nucleobase. In some examples, the click nucleic acid monomer includes a N-vinyl thiol acetamide (VTA) backbone. In other examples the click nucleic acid monomer includes a N-vinyl thiol ethylamine (VTE) backbone. Methods of using such polymers, for example in place of naturally occurring nucleic acid polymer applications, such as DNA or RNA, and synthetic nucleic acid polymer applications, such as PNA or morpholino nucleic acids, are also disclosed.