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公开(公告)号：US09801842B2
公开(公告)日：2017-10-31
申请号：US14299350
申请日：2014-06-09
发明人： James R. Baker, Jr. , Sivaprakash Rathinavelu , Paul E. Makidon , John J. LiPuma , Shraddha Nigavekar
IPC分类号： A61K31/198 , A61K47/32 , A61K33/14 , A61K45/06 , A61K6/00 , A61K9/00 , A61K9/107 , A61K31/22 , A61K31/337 , A61K31/573 , A61K31/7048 , B82Y5/00 , A01N25/04 , A23L29/10 , A23L33/135
CPC分类号： A61K31/198 , A01N25/04 , A23L29/10 , A23L33/135 , A23V2002/00 , A61K6/0008 , A61K9/0078 , A61K9/1075 , A61K31/22 , A61K31/337 , A61K31/573 , A61K31/7048 , A61K33/14 , A61K45/06 , A61K47/32 , B82Y5/00 , A23V2200/25
摘要： The present invention relates to methods and compositions for treating pulmonary infection. In particular, the present invention provides nanoemulsion compositions and methods of using the same to treat bacteria associated with biofilms (e.g., found in pulmonary infections). Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine), industrial, and research applications.
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公开(公告)号：US09259407B2
公开(公告)日：2016-02-16
申请号：US14628886
申请日：2015-02-23
发明人： James R. Baker, Jr. , Mark R. Hemmila , Stewart C. Wang , Tarek Hamouda , John J. LiPuma , Jessica Ann Knowlton , Paul E. Makidon , Luz Blanco , Jeffery V. Groom, II , Anna U. Bielinska
IPC分类号： A61K9/107 , A01N25/04 , A61K45/06 , A61K31/198
CPC分类号： A61K31/198 , A61K9/1075 , A61K31/045 , A61K31/047 , A61K31/14 , A61K31/341 , A61K31/4425 , A61K45/06
摘要： The present invention relates to therapeutic nanoemulsion compositions and to methods of utilizing the same. In particular, nanoemulsion compositions are described herein that find use in the treatment and/or prevention of infection (e.g., respiratory infection (e.g., associated with cystic fibrosis)), in burn wound management, and in immunogenic compositions (e.g., comprising a Burkholderia antigen) that generate an effective immune response (e.g., against a bacterial species of the genus Burkholderia) in a subject administered the immunogenic composition. Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine), industrial, and research applications.
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公开(公告)号：US20140287047A1
公开(公告)日：2014-09-25
申请号：US14299350
申请日：2014-06-09
发明人： James R. Baker, JR. , Sivaprakash Rathinavelu , Paul E. Makidon , John J. LiPuma , Shraddha Nigavekar
IPC分类号： A61K31/198 , A61K33/14 , A61K45/06 , A61K47/32
CPC分类号： A61K31/198 , A01N25/04 , A23L29/10 , A23L33/135 , A23V2002/00 , A61K6/0008 , A61K9/0078 , A61K9/1075 , A61K31/22 , A61K31/337 , A61K31/573 , A61K31/7048 , A61K33/14 , A61K45/06 , A61K47/32 , B82Y5/00 , A23V2200/25
摘要： The present invention relates to methods and compositions for treating pulmonary infection. In particular, the present invention provides nanoemulsion compositions and methods of using the same to treat bacteria associated with biofilms (e.g., found in pulmonary infections). Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine), industrial, and research applications.
摘要翻译： 本发明涉及治疗肺部感染的方法和组合物。 特别地，本发明提供纳米乳剂组合物及其使用方法来治疗与生物膜相关的细菌（例如在肺部感染中发现）。 本发明的组合物和方法尤其可用于临床（例如治疗和预防性药物），工业和研究应用。
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公开(公告)号：US20160158179A1
公开(公告)日：2016-06-09
申请号：US15041173
申请日：2016-02-11
发明人： James R. Baker, Jr. , Mark R. Hemmila , Stewart C. Wang , Tarek Hamouda , John J. LiPuma , Jessica Ann Knowlton , Paul E. Makidon , Luz Blanco , Jeffery V. Groom, II , Anna U. Bielinska
IPC分类号： A61K31/198 , A61K31/4425 , A61K45/06 , A61K31/047 , A61K31/14 , A61K9/107 , A61K31/341 , A61K31/045
CPC分类号： A61K31/198 , A61K9/1075 , A61K31/045 , A61K31/047 , A61K31/14 , A61K31/341 , A61K31/4425 , A61K45/06
摘要： The present invention relates to therapeutic nanoemulsion compositions and to methods of utilizing the same. In particular, nanoemulsion compositions are described herein that find use in the treatment and/or prevention of infection (e.g., respiratory infection (e.g., associated with cystic fibrosis)), in burn wound management, and in immunogenic compositions (e.g., comprising a Burkholderia antigen) that generate an effective immune response (e.g., against a bacterial species of the genus Burkholderia) in a subject administered the immunogenic composition. Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine), industrial, and research applications.
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公开(公告)号：US20150216826A1
公开(公告)日：2015-08-06
申请号：US14628886
申请日：2015-02-23
发明人： James R. Baker, JR. , Mark R. Hemmila , Stewart C. Wang , Tarek Hamouda , John J. LiPuma , Jessica Ann Knowlton , Paul E. Makidon , Luz Blanco , Jeffery V. Groom, II , Anna U. Bielinska
IPC分类号： A61K31/198 , A61K9/107 , A61K45/06
CPC分类号： A61K31/198 , A61K9/1075 , A61K31/045 , A61K31/047 , A61K31/14 , A61K31/341 , A61K31/4425 , A61K45/06
摘要： The present invention relates to therapeutic nanoemulsion compositions and to methods of utilizing the same. In particular, nanoemulsion compositions are described herein that find use in the treatment and/or prevention of infection (e.g., respiratory infection (e.g., associated with cystic fibrosis)), in burn wound management, and in immunogenic compositions (e.g., comprising a Burkholderia antigen) that generate an effective immune response (e.g., against a bacterial species of the genus Burkholderia) in a subject administered the immunogenic composition. Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine), industrial, and research applications.
摘要翻译： 本发明涉及治疗性纳米乳剂组合物及其利用方法。 特别地，本文描述了用于治疗和/或预防感染（例如，呼吸道感染（例如，与囊性纤维化相关）），烧伤伤口管理和免疫原性组合物（例如，包含伯克霍尔德氏菌（Burkholderia））的纳米乳剂组合物 抗原），其在施用免疫原性组合物的受试者中产生有效的免疫应答（例如，针对伯克霍尔德氏菌属的细菌物种）。 本发明的组合物和方法尤其可用于临床（例如治疗和预防性药物），工业和研究应用。
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