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12 条记录 (耗时 0.041 秒)

    Adjuvant compositions
    1.
    发明授权
    Adjuvant compositions 有权

    公开(公告)号：US11173207B2

    公开(公告)日：2021-11-16

    申请号：US16302074

    申请日：2017-05-19

    申请人： The Regents of the University of Michigan ,  NanoBio Corporation

    发明人： James R. Baker, Jr. ,  Douglas M. Smith ,  Susan Ciotti

    IPC分类号： A61K39/39 ,  A61P37/04 ,  A61K39/385 ,  A61K39/295 ,  A61K39/00 ,  A61K9/107

    摘要： The present invention provides methods and compositions for the stimulation of immune responses. In particular, the invention provides methods and compositions for enhancing an immune response to one or more antigens. Compositions and methods of the invention are useful for the treatment and/or prevention of microbial infections, such as infections caused by bacteria, viruses, fungi and parasites, as well as the treatment and/or prevention of cancer and malignant diseases. Compositions and methods of the invention include one or more antigens/immunogens together with an adjuvant formulation comprising an emulsion delivery system in combination with one or more immunostimulatory compounds (e.g., a compound that stimulates the innate immune system (e.g., a toll-like receptor antagonist (e.g., synthetic oligodeoxynucleotides (ODN)))) that enhance immune responses to the one or more antigens/immunogens when administered to a subject. Compositions and methods of the invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination)) and research applications.

    NOVEL ADJUVANT COMPOSITIONS
    3.
    发明申请
    NOVEL ADJUVANT COMPOSITIONS 审中-公开

    公开(公告)号：US20190282693A1

    公开(公告)日：2019-09-19

    申请号：US16302074

    申请日：2017-05-19

    申请人： The Regents of the University of Michigan ,  NanoBio Corporation

    发明人： James R. Baker, Jr. ,  Douglas M. Smith ,  Susan Ciotti

    IPC分类号： A61K39/39 ,  A61K9/107 ,  A61P37/04

    摘要： The present invention provides methods and compositions for the stimulation of immune responses. In particular, the invention provides methods and compositions for enhancing an immune response to one or more antigens. Compositions and methods of the invention are useful for the treatment and/or prevention of microbial infections, such as infections caused by bacteria, viruses, fungi and parasites, as well as the treatment and/or prevention of cancer and malignant diseases. Compositions and methods of the invention include one or more antigens/immunogens together with an adjuvant formulation comprising an emulsion delivery system in combination with one or more immunostimulatory compounds (e.g., a compound that stimulates the innate immune system (e.g., a toll-like receptor antagonist (e.g., synthetic oligodeoxynucleotides (ODN)))) that enhance immune responses to the one or more antigens/immunogens when administered to a subject. Compositions and methods of the invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination)) and research applications.

    Dendrimer conjugates
    6.
    发明授权
    Dendrimer conjugates 有权
    树枝状结合物

    公开(公告)号：US08980907B2

    公开(公告)日：2015-03-17

    申请号：US14107817

    申请日：2013-12-16

    申请人： The Regents of the University of Michigan

    发明人： James R. Baker, Jr. ,  Xue-min Cheng ,  Abraham F. L. Van Der Spek ,  Baohua Mark Huang ,  Thommey P. Thomas

    IPC分类号： A61K31/5513 ,  A61K31/485 ,  A61K31/5377 ,  C07D489/02 ,  C07D413/06 ,  A61K47/48

    CPC分类号： A61K47/483 ,  A61K31/485 ,  A61K47/595

    摘要： The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer-linker conjugates, methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer-linker conjugates of the present invention may further comprise one or more components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy.

    摘要翻译： 本发明涉及新的治疗和诊断树枝状大分子。 特别地，本发明涉及树枝状大分子 - 连接体缀合物，其合成方法，包含缀合物的组合物，以及利用缀合物的系统和方法（例如，在诊断和/或治疗设置（例如，用于递送 治疗，成像和/或靶向剂（例如，在疾病（例如癌症）诊断和/或治疗，疼痛治疗等中））。因此，本发明的树枝状大分子 - 接头缀合物还可包含一种或多种 用于靶向，成像，感测和/或提供治疗或诊断材料和/或监测治疗反应的组分。