公开(公告)号：US20180162906A1

公开(公告)日：2018-06-14

申请号：US15576494

申请日：2016-05-26

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： David H. Sherman ,  Fengan Yu ,  Chuanwu Xi ,  Jianfeng Wu ,  Pamela Schultz ,  Ashootosh Tripathi ,  Sung Ryeol Park

IPC: C07K7/06 ,  C07K5/103 ,  A61K38/07 ,  A01N43/76 ,  A01N37/46 ,  A61K45/06 ,  C12N9/88 ,  C07K14/195

CPC classification number: C07K7/06 ,  A01N37/46 ,  A01N43/76 ,  A61K38/07 ,  A61K45/06 ,  C07D413/12 ,  C07K5/00 ,  C07K5/081 ,  C07K5/1013 ,  C07K14/195 ,  C12N9/88 ,  C12Y402/99021 ,  Y02A50/473

Abstract: Provided herein are biofilm inhibitors obtained from marine microbial derived natural product extracts from Streptomyces gandocaensis, resulting in biofilm inhibitors, cahuitamycins. Also provided are mutant S. gandocaensis, methods of inhibiting biofilm formation, methods of producing, or increasing the production of, cahuitamycins, methods for synthesizing cahuitamycins, and methods of purifying cahuitamycins.