公开(公告)号：US10443100B2

公开(公告)日：2019-10-15

申请号：US15358390

申请日：2016-11-22

申请人： THE SCRIPPS RESEARCH INSTITUTE ,  NORTHWESTERN UNIVERSITY

发明人： Daniel R. Salomon ,  John Friedewald ,  Sunil Kurian ,  Michael M. Abecassis ,  Steve Head ,  Phillip Ordoukhanian

IPC分类号： C12Q1/6883 ,  G16H50/30 ,  G16H50/20 ,  G16B20/00 ,  G16B40/30 ,  G16B40/20 ,  G16B25/10

摘要： By a genome-wide gene analysis of expression profiles of over 50,000 known or putative gene sequences in peripheral blood, the present inventors have identified a consensus set of gene expression-based molecular biomarkers associated with subclinical acute rejection (subAR). These genes sets are useful for diagnosis, prognosis, monitoring of subAR.

公开(公告)号：US20170137885A1

公开(公告)日：2017-05-18

申请号：US15358390

申请日：2016-11-22

申请人： THE SCRIPPS RESEARCH INSTITUTE ,  NORTHWESTERN UNIVERSITY

发明人： Daniel R. Salomon ,  John Friedewald ,  Sunil Kurian ,  Michael M. Abecassis ,  Steven Head ,  Phillip Ordoukhanian

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q2537/165 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158 ,  G16B20/00 ,  G16B25/10 ,  G16B40/20 ,  G16B40/30 ,  G16H50/20 ,  G16H50/30 ,  Y02A90/26

摘要： By a genome-wide gene analysis of expression profiles of over 50,000 known or putative gene sequences in peripheral blood, the present inventors have identified a consensus set of gene expression-based molecular biomarkers associated with subclinical acute rejection (subAR). These genes sets are useful for diagnosis, prognosis, monitoring of subAR.

公开(公告)号：US12060611B2

公开(公告)日：2024-08-13

申请号：US16569119

申请日：2019-09-12

申请人： THE SCRIPPS RESEARCH INSTITUTE ,  NORTHWESTERN UNIVERSITY

发明人： Daniel Salomon ,  John Friedewald ,  Sunil Kurian ,  Michael M. Abecassis ,  Steve Head ,  Phillip Ordoukhanian

IPC分类号： C12Q1/68 ,  C12Q1/6883 ,  G16B20/00 ,  G16B40/20 ,  G16B40/30 ,  G16H20/40 ,  G16H50/20 ,  G16H50/30 ,  G16B25/10

CPC分类号： C12Q1/6883 ,  G16B20/00 ,  G16B40/20 ,  G16B40/30 ,  G16H20/40 ,  G16H50/20 ,  G16H50/30 ,  C12Q2537/165 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158 ,  G16B25/10 ,  Y02A90/10

摘要： By a genome-wide gene analysis of expression profiles of over 50,000 known or putative gene sequences in peripheral blood, the present inventors have identified a consensus set of gene expression-based molecular biomarkers associated with subclinical acute rejection (subAR). These genes sets are useful for diagnosis, prognosis, monitoring of subAR.

公开(公告)号：US20200208217A1

公开(公告)日：2020-07-02

申请号：US16569119

申请日：2019-09-12

申请人： THE SCRIPPS RESEARCH INSTITUTE ,  NORTHWESTERN UNIVERSITY

发明人： Daniel Salomon ,  John Friedewald ,  Sunil Kurian ,  Michael M. Abecassis ,  Steve Head ,  Phillip Ordoukhanian

IPC分类号： C12Q1/6883 ,  G16H50/30 ,  G16H50/20 ,  G16B20/00 ,  G16B40/30 ,  G16B40/20

摘要： By a genome-wide gene analysis of expression profiles of over 50,000 known or putative gene sequences in peripheral blood, the present inventors have identified a consensus set of gene expression-based molecular biomarkers associated with subclinical acute rejection (subAR). These genes sets are useful for diagnosis, prognosis, monitoring of subAR.

公开(公告)号：US10968536B2

公开(公告)日：2021-04-06

申请号：US15553495

申请日：2016-02-25

申请人： JumpCode Genomics, Inc. ,  The Scripps Research Institute

发明人： Keith Brown ,  Daniel R. Salomon ,  Steven Head ,  Azeem Siddique ,  Phillip Ordoukhanian

IPC分类号： C40B40/08 ,  C12N15/10

摘要： Methods, compositions and kits are provided herein for insertional modification of nucleic acids by, for example transposase-mediated covalent insertion of insertion sequence into a sample nucleic acid molecule. Using sequence of the insertion to direct amplification of adjacent nucleic acid sequence, and using bar codes to map amplified sequence to partitions, one can map sample nucleic acid sequence to single molecules of the nucleic acid sample that are derived directly from the sample nucleic acid molecule.

公开(公告)号：US20180237950A1

公开(公告)日：2018-08-23

申请号：US15553495

申请日：2016-02-25

申请人： JumpCode Genomics, Inc. ,  The Scripps Research Institute

发明人： Keith Brown ,  Daniel R. Salomon ,  Steven Head ,  Azeem Siddique ,  Phillip Ordoukhanian

IPC分类号： C40B40/08

CPC分类号： C40B40/08 ,  C12N15/1093

摘要： Methods, compositions and kits are provided herein for insertional modification of nucleic acids by, for example transposase-mediated covalent insertion of insertion sequence into a sample nucleic acid molecule. Using sequence of the insertion to direct amplification of adjacent nucleic acid sequence, and using bar codes to map amplified sequence to partitions, one can map sample nucleic acid sequence to single molecules of the nucleic acid sample that are derived directly from the sample nucleic acid molecule.

公开(公告)号：US20210164128A1

公开(公告)日：2021-06-03

申请号：US17172029

申请日：2021-02-09

申请人： JumpCode Genomics, Inc. ,  The Scripps Research Institute

发明人： Keith Brown ,  Daniel R. Salomon ,  Steven Head ,  Azeem Siddique ,  Phillip Ordoukhanian

IPC分类号： C40B40/08 ,  C12N15/10

摘要： Methods, compositions and kits are provided herein for insertional modification of nucleic acids by, for example transposase-mediated covalent insertion of insertion sequence into a sample nucleic acid molecule. Using sequence of the insertion to direct amplification of adjacent nucleic acid sequence, and using bar codes to map amplified sequence to partitions, one can map sample nucleic acid sequence to single molecules of the nucleic acid sample that are derived directly from the sample nucleic acid molecule.