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公开(公告)号：US10443100B2
公开(公告)日：2019-10-15
申请号：US15358390
申请日：2016-11-22
发明人： Daniel R. Salomon , John Friedewald , Sunil Kurian , Michael M. Abecassis , Steve Head , Phillip Ordoukhanian
摘要： By a genome-wide gene analysis of expression profiles of over 50,000 known or putative gene sequences in peripheral blood, the present inventors have identified a consensus set of gene expression-based molecular biomarkers associated with subclinical acute rejection (subAR). These genes sets are useful for diagnosis, prognosis, monitoring of subAR.
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公开(公告)号：US20170137885A1
公开(公告)日：2017-05-18
申请号：US15358390
申请日：2016-11-22
发明人： Daniel R. Salomon , John Friedewald , Sunil Kurian , Michael M. Abecassis , Steven Head , Phillip Ordoukhanian
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2537/165 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , G16B20/00 , G16B25/10 , G16B40/20 , G16B40/30 , G16H50/20 , G16H50/30 , Y02A90/26
摘要： By a genome-wide gene analysis of expression profiles of over 50,000 known or putative gene sequences in peripheral blood, the present inventors have identified a consensus set of gene expression-based molecular biomarkers associated with subclinical acute rejection (subAR). These genes sets are useful for diagnosis, prognosis, monitoring of subAR.
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公开(公告)号：US20220205042A1
公开(公告)日：2022-06-30
申请号：US17401643
申请日：2021-08-13
IPC分类号： C12Q1/6883 , G01N33/50 , G16H50/30 , G16H20/40 , G16H20/10 , G16H20/17 , G16H50/70 , G16H50/20 , G16H40/63
摘要： By a genome-wide gene analysis of expression profiles of known or putative gene sequences in peripheral blood and biopsy samples, the present inventors have identified a consensus set of gene expression-based molecular biomarkers for distinguishing liver transplantation patients who have Acute Rejection (AR), Hepatitis C Virus Recurrence (HCV-R), both AR/HCV-R, or Acute Dysfunction No Rejection (ADNR). These molecular biomarkers are useful for diagnosis, prognosis and monitoring of liver transplantation patients.
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公开(公告)号：US20170183735A1
公开(公告)日：2017-06-29
申请号：US15313217
申请日：2015-05-22
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2537/165 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G01N33/5088 , G01N2800/245 , G16H10/20 , G16H10/40 , G16H20/10 , G16H20/17 , G16H20/40 , G16H50/20 , G16H50/30 , G16H50/70 , Y02A90/26
摘要： By a genome-wide gene analysis of expression profiles of known or putative gene sequences in peripheral blood and biopsy samples, the present inventors have identified a consensus set of gene expression-based molecular biomarkers for distinguishing liver transplantation patients who have Acute Rejection (AR), Hepatitis C Virus Recurrence (HCV-R), both AR/HCV-R, or Acute Dysfunction No Rejection (ADNR). These molecular biomarkers are useful for diagnosis, prognosis and monitoring of liver transplantation patients.
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公开(公告)号：US12060611B2
公开(公告)日：2024-08-13
申请号：US16569119
申请日：2019-09-12
发明人： Daniel Salomon , John Friedewald , Sunil Kurian , Michael M. Abecassis , Steve Head , Phillip Ordoukhanian
IPC分类号： C12Q1/68 , C12Q1/6883 , G16B20/00 , G16B40/20 , G16B40/30 , G16H20/40 , G16H50/20 , G16H50/30 , G16B25/10
CPC分类号： C12Q1/6883 , G16B20/00 , G16B40/20 , G16B40/30 , G16H20/40 , G16H50/20 , G16H50/30 , C12Q2537/165 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , G16B25/10 , Y02A90/10
摘要： By a genome-wide gene analysis of expression profiles of over 50,000 known or putative gene sequences in peripheral blood, the present inventors have identified a consensus set of gene expression-based molecular biomarkers associated with subclinical acute rejection (subAR). These genes sets are useful for diagnosis, prognosis, monitoring of subAR.
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公开(公告)号：US11104951B2
公开(公告)日：2021-08-31
申请号：US15313217
申请日：2015-05-22
发明人： Daniel Salomon , Josh Levitsky , Sunil Kurian , Michael Abecassis
IPC分类号： C12Q1/6883 , G01N33/574 , G01N33/50 , G16H50/30 , G16H20/40 , G16H20/10 , G16H20/17 , G16H50/70 , G16H50/20 , G16H40/63 , G16H10/20 , G16H10/40
摘要： By a genome-wide gene analysis of expression profiles of known or putative gene sequences in peripheral blood and biopsy samples, the present inventors have identified a consensus set of gene expression-based molecular biomarkers for distinguishing liver transplantation patients who have Acute Rejection (AR), Hepatitis C Virus Recurrence (HCV-R), both AR/HCV-R, or Acute Dysfunction No Rejection (ADNR). These molecular biomarkers are useful for diagnosis, prognosis and monitoring of liver transplantation patients.
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公开(公告)号：US20200208217A1
公开(公告)日：2020-07-02
申请号：US16569119
申请日：2019-09-12
发明人： Daniel Salomon , John Friedewald , Sunil Kurian , Michael M. Abecassis , Steve Head , Phillip Ordoukhanian
摘要： By a genome-wide gene analysis of expression profiles of over 50,000 known or putative gene sequences in peripheral blood, the present inventors have identified a consensus set of gene expression-based molecular biomarkers associated with subclinical acute rejection (subAR). These genes sets are useful for diagnosis, prognosis, monitoring of subAR.
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公开(公告)号：US20170191128A1
公开(公告)日：2017-07-06
申请号：US15313215
申请日：2015-05-22
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6881 , C12Q2537/165 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , C12Q2600/16 , G01N33/6893 , G01N2800/245 , G06F19/3481 , G16B25/00 , G16B40/00 , G16H20/40 , G16H50/30 , Y02A90/26
摘要： By a genome-wide gene analysis of expression profiles of known or putative gene sequences in kidney biopsy samples, the present inventors have identified a consensus set of gene expression-based molecular biomarkers for distinguishing kidney transplantation patients who have Acute Rejection (AR), Acute Dysfunction No Rejection (ADNR), Chronic Allograft Nephropathy(CAN), or Transplant Excellent/Normal (TX). These molecular biomarkers are useful for diagnosis, prognosis and monitoring of transplantation patients.
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