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公开(公告)号：US11357488B2
公开(公告)日：2022-06-14
申请号：US16751436
申请日：2020-01-24
Applicant: THE TEXAS A&M UNIVERSITY SYSTEM
Inventor： Mark A. Wierzbicki , Duncan Maitland , Matthew W. Miller , Andrea D. Muschenborn , Landon Nash , Jason M. Szafron , Todd Landsman
Abstract: A device for a tissue channel includes a device frame, a shape memory polymer foam segment coupled to the device frame, and an attachment structure coupled to the device frame. The device frame includes a proximal structure, a distal structure, and an intermediate structure coupled to the proximal structure and the distal structure. The proximal structure is configured to collapse to fit into a delivery structure and expand to block migration of the proximal structure. The distal structure is configured to collapse to fit into the delivery structure and expand to block migration of the distal structure. The intermediate structure is configured to fit in the tissue channel upon device deployment. The shape memory polymer foam segment is configured to compress to fit into the delivery structure and occlude the channel. The attachment structure is configured to attach and detach the device from a delivery guide.
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公开(公告)号：US12193689B2
公开(公告)日：2025-01-14
申请号：US17881684
申请日：2022-08-05
Inventor： Jason Szafron , Duncan Maitland , Ward Small, IV , Patrick R. Buckley , Andrea D. Muschenborn
IPC: A61B17/22 , A61B17/00 , A61B17/221
Abstract: An embolectomy device comprised of an expansion unit and a support unit is disclosed. The expansion unit can be actuated in response to one or more external stimuli, and the support unit, located proximately to the expansion unit, provides a force to hold the expansion unit in place and to further induce the expansion unit's radial expansion. The radial expansion of the expansion unit causes the expansion unit to physically contact a blood clot, enabling the blood clot to be removed. In some embodiments, the expansion unit can be fabricated from a shape memory polymer foam. In some embodiments the support unit can be fabricated from any elastic material including, without limitation, shape memory alloys.
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公开(公告)号：US11406401B2
公开(公告)日：2022-08-09
申请号：US16701417
申请日：2019-12-03
Inventor： Jason Szafron , Duncan Maitland , Ward Small, IV , Patrick R. Buckley , Andrea D. Muschenborn
IPC: A61B17/22 , A61B17/221 , A61B17/00
Abstract: An embolectomy device comprised of an expansion unit and a support unit is disclosed. The expansion unit can be actuated in response to one or more external stimuli, and the support unit, located proximately to the expansion unit, provides a force to hold the expansion unit in place and to further induce the expansion unit's radial expansion. The radial expansion of the expansion unit causes the expansion unit to physically contact a blood clot, enabling the blood clot to be removed. In some embodiments, the expansion unit can be fabricated from a shape memory polymer foam. In some embodiments the support unit can be fabricated from any elastic material including, without limitation, shape memory alloys.
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公开(公告)号：US20200155131A1
公开(公告)日：2020-05-21
申请号：US16751436
申请日：2020-01-24
Applicant: THE TEXAS A&M UNIVERSITY SYSTEM
Inventor： Mark A. Wierzbicki , Duncan Maitland , Matthew W. Miller , Andrea D. Muschenborn , Landon Nash , Jason M. Szafron , Todd Landsman
IPC: A61B17/00
Abstract: A device for a tissue channel includes a device frame, a shape memory polymer foam segment coupled to the device frame, and an attachment structure coupled to the device frame. The device frame includes a proximal structure, a distal structure, and an intermediate structure coupled to the proximal structure and the distal structure. The proximal structure is configured to collapse to fit into a delivery structure and expand to block migration of the proximal structure. The distal structure is configured to collapse to fit into the delivery structure and expand to block migration of the distal structure. The intermediate structure is configured to fit in the tissue channel upon device deployment. The shape memory polymer foam segment is configured to compress to fit into the delivery structure and occlude the channel. The attachment structure is configured to attach and detach the device from a delivery guide.
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公开(公告)号：US20250143684A1
公开(公告)日：2025-05-08
申请号：US19018495
申请日：2025-01-13
Applicant: THE TEXAS A&M UNIVERSITY SYSTEM
Inventor： Mark Wierzbicki , Duncan Maitland , Matthew W. Miller , Andrea D. Muschenborn , Landon Nash , Jason M. Szafron , Todd Landsman
Abstract: A device for a tissue channel includes a device frame, a shape memory polymer foam segment coupled to the device frame, and an attachment structure coupled to the device frame. The device frame includes a proximal structure, a distal structure, and an intermediate structure coupled to the proximal structure and the distal structure. The proximal structure is configured to collapse to fit into a delivery structure and expand to block migration of the proximal structure. The distal structure is configured to collapse to fit into the delivery structure and expand to block migration of the distal structure. The intermediate structure is configured to fit in the tissue channel upon device deployment. The shape memory polymer foam segment is configured to compress to fit into the delivery structure and occlude the channel. The attachment structure is configured to attach and detach the device from a delivery guide.
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Patent Agency Ranking
公开(公告)号：US20240416011A1
公开(公告)日：2024-12-19
申请号：US18820428
申请日：2024-08-30
Applicant: The Texas A&M University System
Inventor： Duncan Maitland , Corey Bishop , Shreedevi Arun Kumar
Abstract: Tumor resection is commonly practiced to prevent the progression of cancer. However, there are post-surgery concerns including the formation of a void that can allow cancer cells to escape at the surgery site, which increases the risk of metastasis. To counter this challenge, an embodiment includes a polyurethane-based shape memory foam as a tissue void-filling device that can also release anti-cancer drugs. Such foams may activate at body temperature and become malleable. Such properties may enable the foam to be shaped to precisely seal the tissue void and then serve as a drug-eluting device. Based on the drug composition with poly vinyl alcohol (PVA), the drug release profile from the foam may be altered depending on the application.
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公开(公告)号：US12076464B2
公开(公告)日：2024-09-03
申请号：US17072166
申请日：2020-10-16
Applicant: The Texas A&M University System
Inventor： Duncan Maitland , Corey Bishop , Shreedevi Arun Kumar
CPC classification number: A61L27/56 , A61L27/18 , A61L27/54 , C08G18/3206 , C08G18/341 , C08G18/3825 , C08G18/73 , A61L2300/626 , A61L2300/802 , A61L2400/16 , C08G2101/00 , C08G2280/00
Abstract: Tumor resection is commonly practiced to prevent the progression of cancer. However, there are post-surgery concerns including the formation of a void that can allow cancer cells to escape at the surgery site, which increases the risk of metastasis. To counter this challenge, an embodiment includes a polyurethane-based shape memory foam as a tissue void-filling device that can also release anti-cancer drugs. Such foams may activate at body temperature and become malleable. Such properties may enable the foam to be shaped to precisely seal the tissue void and then serve as a drug-eluting device. Based on the drug composition with poly vinyl alcohol (PVA), the drug release profile from the foam may be altered depending on the application.
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公开(公告)号：US20210113741A1
公开(公告)日：2021-04-22
申请号：US17072166
申请日：2020-10-16
Applicant: The Texas A&M University System
Inventor： Duncan Maitland , Corey Bishop , Shreedevi Arun Kumar
Abstract: Tumor resection is commonly practiced to prevent the progression of cancer. However, there are post-surgery concerns including the formation of a void that can allow cancer cells to escape at the surgery site, which increases the risk of metastasis. To counter this challenge, an embodiment includes a polyurethane-based shape memory foam as a tissue void-filling device that can also release anti-cancer drugs. Such foams may activate at body temperature and become malleable. Such properties may enable the foam to be shaped to precisely seal the tissue void and then serve as a drug-eluting device. Based on the drug composition with poly vinyl alcohol (PVA), the drug release profile from the foam may be altered depending on the application.
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公开(公告)号：US20160317166A1
公开(公告)日：2016-11-03
申请号：US15094701
申请日：2016-04-08
Inventor： Jason Szafron , Duncan Maitland , Ward Small, IV , Patrick Buckley , Andrea D. Müschenborn
IPC: A61B17/221 , A61M29/02
CPC classification number: A61B17/22 , A61B2017/00526 , A61B2017/00867 , A61B2017/00871 , A61B2017/22094 , A61B2017/2212
Abstract: An embolectomy device comprised of an expansion unit and a support unit is disclosed. The expansion unit can be actuated in response to one or more external stimuli, and the support unit, located proximately to the expansion unit, provides a force to hold the expansion unit in place and to further induce the expansion unit's radial expansion. The radial expansion of the expansion unit causes the expansion unit to physically contact a blood clot, enabling the blood clot to be removed. In some embodiments, the expansion unit can be fabricated from a shape memory polymer foam. In some embodiments the support unit can be fabricated from any elastic material including, without limitation, shape memory alloys.
Abstract translation: 公开了一种由膨胀单元和支撑单元构成的止血器的结构。 可以响应于一个或多个外部刺激来致动膨胀单元，并且位于膨胀单元附近的支撑单元提供力以将膨胀单元保持在适当位置并进一步引起膨胀单元的径向膨胀。 膨胀单元的径向膨胀使膨胀单元物理接触血块，从而能够去除血块。 在一些实施例中，膨胀单元可以由形状记忆聚合物泡沫制成。 在一些实施例中，支撑单元可以由包括但不限于形状记忆合金的任何弹性材料制成。
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公开(公告)号：US12239304B2
公开(公告)日：2025-03-04
申请号：US17837111
申请日：2022-06-10
Applicant: THE TEXAS A&M UNIVERSITY SYSTEM
Inventor： Mark A. Wierzbicki , Duncan Maitland , Matthew W. Miller , Andrea D. Muschenborn , Landon Nash , Jason M. Szafron , Todd Landsman
Abstract: A device for a tissue channel includes a device frame, a shape memory polymer foam segment coupled to the device frame, and an attachment structure coupled to the device frame. The device frame includes a proximal structure, a distal structure, and an intermediate structure coupled to the proximal structure and the distal structure. The proximal structure is configured to collapse to fit into a delivery structure and expand to block migration of the proximal structure. The distal structure is configured to collapse to fit into the delivery structure and expand to block migration of the distal structure. The intermediate structure is configured to fit in the tissue channel upon device deployment. The shape memory polymer foam segment is configured to compress to fit into the delivery structure and occlude the channel. The attachment structure is configured to attach and detach the device from a delivery guide.
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