公开(公告)号：US10198817B2

公开(公告)日：2019-02-05

申请号：US15304611

申请日：2015-04-17

Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

Inventor： Scott A. Small ,  Frank A. Provenzano ,  Usman A. Khan

IPC: G06K9/00 ,  G06T7/00 ,  G06T5/50 ,  G06T7/11 ,  G06T7/136 ,  G06T5/20

Abstract: A technology which enables identifying, via a computer, a vessel in a third image. The third image is obtained from a subtraction of a second image from a first image. The second image and the first image are aligned on an imaging space. The first image is post-contrast. The second image is pre-contrast. The technology enables determining, via the computer, a voxel intensity mean value of a segment of the vessel in the third image. The technology enables obtaining, via the computer, a fourth image from a division of the third image by the voxel intensity mean value. The technology enables applying, via the computer, a filter onto the fourth image. The technology enables generating, via the computer, a filter mask based on the fourth image.

公开(公告)号：US20170039714A1

公开(公告)日：2017-02-09

申请号：US15304611

申请日：2015-04-17

Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

Inventor： Scott A. Small ,  Frank A. Provenzano ,  Usman A. Khan

IPC: G06T7/00

CPC classification number: G06T7/0016 ,  G06T5/20 ,  G06T5/50 ,  G06T7/11 ,  G06T7/136 ,  G06T2207/10088 ,  G06T2207/20224 ,  G06T2207/30016 ,  G06T2207/30101

Abstract: A technology which enables identifying, via a computer, a vessel in a third image. The third image is obtained from a subtraction of a second image from a first image. The second image and the first image are aligned on an imaging space. The first image is post-contrast. The second image is pre-contrast. The technology enables determining, via the computer, a voxel intensity mean value of a segment of the vessel in the third image. The technology enables obtaining, via the computer, a fourth image from a division of the third image by the voxel intensity mean value. The technology enables applying, via the computer, a filter onto the fourth image. The technology enables generating, via the computer, a filter mask based on the fourth image.

Abstract translation: 一种能够通过计算机识别第三个图像中的血管的技术。 从第一图像的第二图像的减法中获得第三图像。 第二图像和第一图像在成像空间上对准。 第一张图像是对比后。 第二张图像是对比度。 该技术使得能够经由计算机确定第三图像中的血管段的体素强度平均值。 该技术能够通过计算机获得来自第三图像的划分的体素强度平均值的第四图像。 该技术能够通过计算机将滤波器应用于第四图像。 该技术能够通过计算机生成基于第四图像的滤光罩。

公开(公告)号：US12182969B2

公开(公告)日：2024-12-31

申请号：US17347917

申请日：2021-06-15

Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

Inventor： Jia Guo ,  Scott A. Small

IPC: G06T5/00 ,  G06T5/50 ,  G16H30/20 ,  G16H30/40 ,  G16H50/20 ,  G16H50/50

Abstract: An exemplary system, method, and computer-accessible medium for detection of functional disorder(s) or aging progression of patient(s) can be provided which can include, for example, receiving magnetic resonance imaging (MRI) information of the portion(s), generating gadolinium (“Gd”) enhanced map(s) based on the MRI information using a machine learning procedure(s), and detecting the functional disorder(s) or aging progression of the patient(s) based on the Gd enhanced map(s). The Gd enhanced map(s) can be a full dosage Gd enhanced map which can be a full dosage Gd enhanced cerebral blood volume map(s). The machine learning procedure can be a convolutional neural network. The MRI information can include (i) a low-dosage Gd MRI scan(s), and/or (ii) a Gd-free MRI scan(s). Functional disorder(s) or age progression can include a neurodegenerative disease, a neuropsychiatric disease, a neurodevelopment disorder or aging.

公开(公告)号：US12100121B2

公开(公告)日：2024-09-24

申请号：US17347948

申请日：2021-06-15

Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

Inventor： Jia Guo ,  Scott A. Small

IPC: G06T5/00 ,  G06T5/50 ,  G16H30/20 ,  G16H30/40 ,  G16H50/20 ,  G16H50/50

CPC classification number: G06T5/00 ,  G06T5/50 ,  G16H30/20 ,  G16H30/40 ,  G16H50/20 ,  G16H50/50 ,  G06T2207/10096 ,  G06T2207/20081 ,  G06T2207/20084 ,  G06T2207/30016

Abstract: An exemplary system, method, and computer-accessible medium for detection of structural disorder(s) of patient(s) can be provided which can include, for example, receiving magnetic resonance imaging (MRI) information of the portion(s), generating gadolinium (“Gd”) enhanced map(s) based on the MRI information using a machine learning procedure(s), and detecting the structural disorder(s) of the patient(s) based on a GD contrast of the Gd enhanced map(s). The Gd enhanced map(s) can be a full dosage Gd enhanced map. The machine learning procedure can be a convolutional neural network. The MRI information can include (i) a low-dosage Gd MRI scan(s), or (ii) a Gd-free MRI scan(s). The Gd contrast can be generated in the Gd enhanced map(s) using a T2-weighted MRI image of the portion(s). Structural disorder(s) can include Stroke, tumor, trauma, infection, Multiple sclerosis and/or other inflammatory disease.

公开(公告)号：US20150361063A1

公开(公告)日：2015-12-17

申请号：US14832941

申请日：2015-08-21

Applicant: Brandeis University ,  The Trustees of Columbia University in the City of New York

Inventor： Dagmar Ringe ,  Gregory A. Petsko ,  Scott A. Small ,  Vincent Mecozzi

IPC: C07D333/18 ,  A61K31/381

CPC classification number: C07D333/18 ,  A61K31/155 ,  A61K31/195 ,  A61K31/38 ,  A61K31/381 ,  C07D333/24 ,  C07K14/47

Abstract: The present invention provides pharmaceutical compositions and related methods for stabilizing retromer in cells.

Abstract translation: 本发明提供药物组合物和相关方法，用于稳定细胞中的重新起搏器。