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1.发明申请公开(公告)号：US20170233370A1
公开(公告)日：2017-08-17
申请号：US15442475
申请日：2017-02-24
IPC分类号： C07D401/12 , A61K31/245 , A61K45/06 , C07D309/14 , A61K31/351 , C07D211/58 , A61K31/4468 , C07C271/24 , A61K31/27 , C07D295/30 , A61K31/495 , C07D295/088 , A61K31/5375 , C07D213/74 , A61K31/44 , C07D239/42 , A61K31/505 , A61K31/444 , A61K31/506 , C07C225/22
CPC分类号： C07D401/12 , A61K31/245 , A61K31/27 , A61K31/325 , A61K31/351 , A61K31/44 , A61K31/444 , A61K31/4465 , A61K31/4468 , A61K31/495 , A61K31/505 , A61K31/506 , A61K31/5375 , A61K45/06 , C07C69/78 , C07C205/57 , C07C205/58 , C07C211/50 , C07C225/22 , C07C229/60 , C07C233/54 , C07C237/30 , C07C255/58 , C07C271/16 , C07C271/24 , C07C271/28 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2601/20 , C07C2603/74 , C07D211/58 , C07D213/36 , C07D213/74 , C07D213/80 , C07D239/26 , C07D239/42 , C07D295/088 , C07D295/192 , C07D295/30 , C07D309/14
摘要： The present invention provides, inter alia, a compound having the structure: Also provided are compositions containing a pharmaceutically acceptable carrier and a compound according to the present invention. Further provided are methods for treating or ameliorating the effects of an excitotoxic disorder in a subject, methods of modulating ferroptosis in a subject, methods of reducing reactive oxygen species (ROS) in a cell, and methods for treating or ameliorating the effects of a neurodegenerative disease.
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2.发明授权公开(公告)号：US09580398B2
公开(公告)日：2017-02-28
申请号：US14390256
申请日：2013-04-02
IPC分类号： C07D213/80 , C07C211/50 , A61K31/44 , A61K31/245 , C07D309/14 , C07C255/58 , C07C271/16 , C07C271/24 , C07C271/28 , C07C205/57 , C07C205/58 , C07D401/12 , C07D239/26 , C07C229/60 , C07C233/54 , C07C237/30 , C07D295/088 , C07D211/58 , C07D295/30 , C07D213/36 , A61K31/325 , A61K31/351 , A61K31/4465 , A61K31/495 , A61K31/5375 , A61K45/06 , C07C69/78 , C07D295/192
CPC分类号： C07D401/12 , A61K31/245 , A61K31/27 , A61K31/325 , A61K31/351 , A61K31/44 , A61K31/444 , A61K31/4465 , A61K31/4468 , A61K31/495 , A61K31/505 , A61K31/506 , A61K31/5375 , A61K45/06 , C07C69/78 , C07C205/57 , C07C205/58 , C07C211/50 , C07C225/22 , C07C229/60 , C07C233/54 , C07C237/30 , C07C255/58 , C07C271/16 , C07C271/24 , C07C271/28 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2601/20 , C07C2603/74 , C07D211/58 , C07D213/36 , C07D213/74 , C07D213/80 , C07D239/26 , C07D239/42 , C07D295/088 , C07D295/192 , C07D295/30 , C07D309/14
摘要： The present invention provides, inter alia, a compound having the structure: (Formula (I). Also provided are compositions containing a pharmaceutically acceptable carrier and a compound according to the present invention. Further provided are methods for treating or ameliorating the effects of an excitotoxic disorder in a subject, methods of modulating ferroptosis in a subject, methods of reducing reactive oxygen species (ROS) in a cell, and methods for treating or ameliorating the effects of a neurodegenerative disease.
摘要翻译： 本发明尤其提供具有以下结构的化合物：（式（I）），还提供含有药学上可接受的载体和本发明化合物的组合物，还提供了治疗或改善 受试者中的兴奋性毒性障碍，受试者中的热of症调节方法，还原细胞中的活性氧（ROS）的方法，以及治疗或改善神经变性疾病的作用的方法。
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3.发明申请Compounds, Compositions, and Methods For Modulating Ferroptosis and Treating Excitotoxic Disorders 有权化合物，组合物和调节热障和治疗兴奋性毒性障碍的方法公开(公告)号：US20150079035A1
公开(公告)日：2015-03-19
申请号：US14390256
申请日：2013-04-02
IPC分类号： C07D309/14 , A61K31/245 , A61K45/06 , A61K31/351 , A61K31/5375 , A61K31/4465 , C07D295/30 , C07C271/28 , A61K31/325 , A61K31/495 , C07C69/78 , C07D295/192
CPC分类号： C07D401/12 , A61K31/245 , A61K31/27 , A61K31/325 , A61K31/351 , A61K31/44 , A61K31/444 , A61K31/4465 , A61K31/4468 , A61K31/495 , A61K31/505 , A61K31/506 , A61K31/5375 , A61K45/06 , C07C69/78 , C07C205/57 , C07C205/58 , C07C211/50 , C07C225/22 , C07C229/60 , C07C233/54 , C07C237/30 , C07C255/58 , C07C271/16 , C07C271/24 , C07C271/28 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2601/20 , C07C2603/74 , C07D211/58 , C07D213/36 , C07D213/74 , C07D213/80 , C07D239/26 , C07D239/42 , C07D295/088 , C07D295/192 , C07D295/30 , C07D309/14
摘要： The present invention provides, inter alia, a compound having the structure: (Formula (I). Also provided are compositions containing a pharmaceutically acceptable carrier and a compound according to the present invention. Further provided are methods for treating or ameliorating the effects of an excitotoxic disorder in a subject, methods of modulating ferroptosis in a subject, methods of reducing reactive oxygen species (ROS) in a cell, and methods for treating or ameliorating the effects of a neurodegenerative disease.
摘要翻译： 本发明尤其提供具有以下结构的化合物：（式（I）），还提供含有药学上可接受的载体和本发明化合物的组合物，还提供了治疗或改善 受试者中的兴奋性毒性障碍，受试者中的热of症调节方法，还原细胞中的活性氧（ROS）的方法，以及治疗或改善神经变性疾病的作用的方法。
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4.发明授权公开(公告)号：US10233171B2
公开(公告)日：2019-03-19
申请号：US15442475
申请日：2017-02-24
IPC分类号： C07D213/74 , A61K31/47 , C07D401/12 , C07D309/14 , C07C255/58 , C07D213/80 , C07C271/16 , C07C271/24 , C07C271/28 , C07C205/57 , C07C205/58 , C07C211/50 , C07D239/26 , C07C229/60 , C07C233/54 , C07C237/30 , C07D295/088 , C07D211/58 , C07D295/30 , C07D213/36 , A61K31/245 , A61K31/325 , A61K31/351 , A61K31/4465 , A61K31/495 , A61K31/5375 , A61K45/06 , C07C69/78 , C07D295/192 , A61K31/27 , A61K31/44 , A61K31/444 , A61K31/4468 , A61K31/505 , A61K31/506 , C07C225/22 , C07D239/42
摘要： The present invention provides, inter alia, a compound having the structure: Also provided are compositions containing a pharmaceutically acceptable carrier and a compound according to the present invention. Further provided are methods for treating or ameliorating the effects of an excitotoxic disorder in a subject, methods of modulating ferroptosis in a subject, methods of reducing reactive oxygen species (ROS) in a cell, and methods for treating or ameliorating the effects of a neurodegenerative disease.
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5.发明授权公开(公告)号：US10597381B2
公开(公告)日：2020-03-24
申请号：US16247354
申请日：2019-01-14
IPC分类号： C07C225/22 , C07C69/78 , A61K31/245 , C07D401/12 , C07C255/58 , C07D213/80 , C07C271/16 , C07C271/24 , C07C271/28 , C07C205/57 , C07C205/58 , C07C211/50 , C07D239/26 , C07C229/60 , C07C233/54 , C07C237/30 , C07D295/088 , C07D211/58 , C07D295/30 , C07D213/36 , C07D309/14 , A61K31/325 , A61K31/351 , A61K31/4465 , A61K31/495 , A61K31/5375 , A61K45/06 , C07D295/192 , A61K31/27 , A61K31/44 , A61K31/444 , A61K31/4468 , A61K31/505 , A61K31/506 , C07D213/74 , C07D239/42
摘要： The present invention provides, inter alia, a compound having the structure: Also provided are compositions containing a pharmaceutically acceptable carrier and a compound according to the present invention. Further provided are methods for treating or ameliorating the effects of an excitotoxic disorder in a subject, methods of modulating ferroptosis in a subject, methods of reducing reactive oxygen species (ROS) in a cell, and methods for treating or ameliorating the effects of a neurodegenerative disease.
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6.发明申请公开(公告)号：US20190135782A1
公开(公告)日：2019-05-09
申请号：US16247354
申请日：2019-01-14
IPC分类号： C07D401/12 , A61K31/245 , C07D213/80 , C07C271/16 , C07C271/24 , C07C271/28 , C07C205/57 , C07C205/58 , C07C225/22 , A61K31/444 , A61K31/4468 , A61K31/505 , A61K31/506 , C07D239/42 , C07D213/74 , A61K31/27 , A61K31/44 , C07D309/14 , A61K31/325 , A61K45/06 , C07C69/78 , C07C255/58 , C07D295/192 , A61K31/351 , A61K31/4465 , A61K31/495 , A61K31/5375 , C07D213/36 , C07D295/30 , C07D211/58 , C07D295/088 , C07C237/30 , C07C233/54 , C07C229/60 , C07D239/26 , C07C211/50
CPC分类号： C07D401/12 , A61K31/245 , A61K31/27 , A61K31/325 , A61K31/351 , A61K31/44 , A61K31/444 , A61K31/4465 , A61K31/4468 , A61K31/495 , A61K31/505 , A61K31/506 , A61K31/5375 , A61K45/06 , C07C69/78 , C07C205/57 , C07C205/58 , C07C211/50 , C07C225/22 , C07C229/60 , C07C233/54 , C07C237/30 , C07C255/58 , C07C271/16 , C07C271/24 , C07C271/28 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2601/20 , C07C2603/74 , C07D211/58 , C07D213/36 , C07D213/74 , C07D213/80 , C07D239/26 , C07D239/42 , C07D295/088 , C07D295/192 , C07D295/30 , C07D309/14
摘要： The present invention provides, inter alia, a compound having the structure: Also provided are compositions containing a pharmaceutically acceptable carrier and a compound according to the present invention. Further provided are methods for treating or ameliorating the effects of an excitotoxic disorder in a subject, methods of modulating ferroptosis in a subject, methods of reducing reactive oxygen species (ROS) in a cell, and methods for treating or ameliorating the effects of a neurodegenerative disease.
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