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公开(公告)号：US20220002342A1
公开(公告)日：2022-01-06
申请号：US17469102
申请日：2021-09-08
Applicant: THE TRUSTEES OF PRINCETON UNIVERSITY
Inventor： David MACMILLAN , Daniel Novoa , Stefan McCarver
Abstract: Synthetic methods are described herein operable to efficiently produce a wide variety of molecular species through conjugate additions via decarboxylative mechanisms. For example, methods of functionalization of peptide residues are described, including selective functionalization of peptide C-terminal residues. In one aspect, a method of peptide functionalization comprises providing a reaction mixture including a Michael acceptor and a peptide and coupling the Michael acceptor with the peptide via a mechanism including decarboxylation of a peptide reside.
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公开(公告)号：US11136349B2
公开(公告)日：2021-10-05
申请号：US15579741
申请日：2016-06-03
Applicant: The Trustees of Princeton University
Inventor： David MacMillan , Daniel Novoa , Stefan McCarver
Abstract: Synthetic methods are described herein operable to efficiently produce a wide variety of molecular species through conjugate additions via decarboxylative mechanisms. For example, methods of functionalization of peptide residues are described, including selective functionalization of peptide C-terminal residues. In one aspect, a method of peptide functionalization comprises providing a reaction mixture including a Michael acceptor and a peptide and coupling the Michael acceptor with the peptide via a mechanism including decarboxylation of a peptide reside.
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公开(公告)号：US20240287129A1
公开(公告)日：2024-08-29
申请号：US18640494
申请日：2024-04-19
Applicant: THE TRUSTEES OF PRINCETON UNIVERSITY
Inventor： David MacMillan , Daniel Novoa , Stefan McCarver
CPC classification number: C07K1/113 , B01J31/181 , B01J31/1815 , B01J35/39 , C07K1/107 , C07K5/0205 , C25B3/29 , B01J2231/324 , B01J2231/348 , B01J2531/827 , B01J2540/12 , B01J2540/22 , B01J2540/225
Abstract: Synthetic methods are described herein operable to efficiently produce a wide variety of molecular species through conjugate additions via decarboxylative mechanisms. For example, methods of functionalization of peptide residues are described, including selective functionalization of peptide C-terminal residues. In one aspect, a method of peptide functionalization comprises providing a reaction mixture including a Michael acceptor and a peptide and coupling the Michael acceptor with the peptide via a mechanism including decarboxylation of a peptide reside.
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公开(公告)号：US11981704B2
公开(公告)日：2024-05-14
申请号：US17469102
申请日：2021-09-08
Applicant: THE TRUSTEES OF PRINCETON UNIVERSITY
Inventor： David MacMillan , Daniel Novoa , Stefan McCarver
CPC classification number: C07K1/113 , B01J31/181 , B01J31/1815 , B01J35/004 , C07K1/107 , C07K5/0205 , C25B3/29 , B01J2231/324 , B01J2231/348 , B01J2531/827 , B01J2540/12 , B01J2540/22 , B01J2540/225
Abstract: Synthetic methods are described herein operable to efficiently produce a wide variety of molecular species through conjugate additions via decarboxylative mechanisms. For example, methods of functionalization of peptide residues are described, including selective functionalization of peptide C-terminal residues. In one aspect, a method of peptide functionalization comprises providing a reaction mixture including a Michael acceptor and a peptide and coupling the Michael acceptor with the peptide via a mechanism including decarboxylation of a peptide reside.
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