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公开(公告)号：US11136349B2
公开(公告)日：2021-10-05
申请号：US15579741
申请日：2016-06-03
发明人： David MacMillan , Daniel Novoa , Stefan McCarver
摘要： Synthetic methods are described herein operable to efficiently produce a wide variety of molecular species through conjugate additions via decarboxylative mechanisms. For example, methods of functionalization of peptide residues are described, including selective functionalization of peptide C-terminal residues. In one aspect, a method of peptide functionalization comprises providing a reaction mixture including a Michael acceptor and a peptide and coupling the Michael acceptor with the peptide via a mechanism including decarboxylation of a peptide reside.
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公开(公告)号：US20240287129A1
公开(公告)日：2024-08-29
申请号：US18640494
申请日：2024-04-19
发明人： David MacMillan , Daniel Novoa , Stefan McCarver
CPC分类号： C07K1/113 , B01J31/181 , B01J31/1815 , B01J35/39 , C07K1/107 , C07K5/0205 , C25B3/29 , B01J2231/324 , B01J2231/348 , B01J2531/827 , B01J2540/12 , B01J2540/22 , B01J2540/225
摘要： Synthetic methods are described herein operable to efficiently produce a wide variety of molecular species through conjugate additions via decarboxylative mechanisms. For example, methods of functionalization of peptide residues are described, including selective functionalization of peptide C-terminal residues. In one aspect, a method of peptide functionalization comprises providing a reaction mixture including a Michael acceptor and a peptide and coupling the Michael acceptor with the peptide via a mechanism including decarboxylation of a peptide reside.
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公开(公告)号：US11981704B2
公开(公告)日：2024-05-14
申请号：US17469102
申请日：2021-09-08
发明人： David MacMillan , Daniel Novoa , Stefan McCarver
CPC分类号： C07K1/113 , B01J31/181 , B01J31/1815 , B01J35/004 , C07K1/107 , C07K5/0205 , C25B3/29 , B01J2231/324 , B01J2231/348 , B01J2531/827 , B01J2540/12 , B01J2540/22 , B01J2540/225
摘要： Synthetic methods are described herein operable to efficiently produce a wide variety of molecular species through conjugate additions via decarboxylative mechanisms. For example, methods of functionalization of peptide residues are described, including selective functionalization of peptide C-terminal residues. In one aspect, a method of peptide functionalization comprises providing a reaction mixture including a Michael acceptor and a peptide and coupling the Michael acceptor with the peptide via a mechanism including decarboxylation of a peptide reside.
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公开(公告)号：US20150335657A1
公开(公告)日：2015-11-26
申请号：US14703371
申请日：2015-05-04
发明人： Thomas Shenk , Emre Koyuncu , Hahn Kim , Ileana Cristea , David MacMillan
IPC分类号： A61K31/554 , A61K31/519 , A61K45/06 , A61K31/502 , A61K31/4709 , A61K31/4155 , A61K31/444 , A61K31/4439 , A61K31/42 , A61K31/4178 , A61K31/4164 , A61K31/553 , A61K31/4412 , A61K31/496 , A61K31/4015 , A61K31/415 , A61K31/4725 , A61K31/501 , A61K31/47
CPC分类号： A61K31/554 , A61K31/4015 , A61K31/4045 , A61K31/415 , A61K31/4155 , A61K31/4164 , A61K31/4178 , A61K31/42 , A61K31/44 , A61K31/4412 , A61K31/4439 , A61K31/444 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/498 , A61K31/501 , A61K31/502 , A61K31/519 , A61K31/553 , A61K45/06 , Y02A50/467
摘要： This document relates to compounds useful for modulating sirtuin enzymes. For example, the compounds provided herein are useful as broad spectrum antiviral agents. In addition, the compounds provided herein may be used in the treatment of other disorders associated with sirtuin enzymes, such as diseases related to aging and stress, blood clotting disorders, cancer, cardiovascular diseases, diabetes, inflammation, neurodegenerative diseases, and obesity.
摘要翻译： 本文件涉及可用于调节沉默调节蛋白酶的化合物。 例如，本文提供的化合物可用作广谱抗病毒剂。 此外，本文提供的化合物可用于治疗与沉默调节蛋白酶相关的其它疾病，例如与衰老和压力相关的疾病，凝血障碍，癌症，心血管疾病，糖尿病，炎症，神经变性疾病和肥胖症。
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