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公开(公告)号：US20160120832A1
公开(公告)日：2016-05-05
申请号：US14890106
申请日：2014-05-09
IPC分类号： A61K31/20 , G01N33/574 , A61K45/06
CPC分类号： A61K31/20 , A23L33/10 , A23L33/115 , A23L33/12 , A23L33/17 , A23V2002/00 , A61K31/202 , A61K31/66 , A61K31/685 , A61K36/889 , A61K45/06 , G01N33/5748 , G01N2500/10 , G01N2800/52 , A61K2300/00 , A23V2200/308 , A23V2250/18 , A23V2250/186
摘要： Methods and compositions for treating Ras-related cancers are provided that involve targeting lipid scavenging. Methods and compositions for identifying and/or characterizing more or less responsive cancers are also provided.
摘要翻译： 提供了用于治疗Ras相关癌症的方法和组合物，其涉及靶向脂质清除。 还提供了用于鉴定和/或表征更多或更少反应性癌症的方法和组合物。
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公开(公告)号：US20190046489A1
公开(公告)日：2019-02-14
申请号：US16160237
申请日：2018-10-15
IPC分类号： A61K31/20 , A23L33/12 , A23L33/17 , A23L33/115 , G01N33/574 , A61K31/202 , A61K45/06 , A23L33/10 , A61K31/685 , A61K36/889 , A61K31/66
摘要： Methods and compositions for treating Ras-related cancers are provided that involve targeting lipid scavenging. Methods and compositions for identifying and/or characterizing more or less responsive cancers are also provided.
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公开(公告)号：US20220023551A1
公开(公告)日：2022-01-27
申请号：US17499151
申请日：2021-10-12
发明人： Joshua Rabinowitz
摘要： The present invention an electronic inhaler for the delivery of pharmaceuticals through vaporization.
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公开(公告)号：US11154667B2
公开(公告)日：2021-10-26
申请号：US16096901
申请日：2017-04-27
发明人： Joshua Rabinowitz
摘要： The present invention an electronic inhaler for the delivery of pharmaceuticals through vaporization.
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公开(公告)号：US10772862B2
公开(公告)日：2020-09-15
申请号：US16160237
申请日：2018-10-15
IPC分类号： A61K31/20 , A61K45/06 , A61K31/202 , G01N33/574 , A23L33/10 , A23L33/115 , A23L33/12 , A23L33/17 , A61K31/685 , A61K31/66 , A61K36/889
摘要： Methods and compositions for treating Ras-related cancers are provided that involve targeting lipid scavenging. Methods and compositions for identifying and/or characterizing more or less responsive cancers are also provided.
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公开(公告)号：US10130600B2
公开(公告)日：2018-11-20
申请号：US14890106
申请日：2014-05-09
IPC分类号： A61K31/20 , A61K31/66 , A61K45/06 , A61K31/202 , G01N33/574 , A23L33/10 , A23L33/115 , A23L33/12 , A23L33/17 , A61K31/685 , A61K36/889
摘要： Methods and compositions for treating Ras-related cancers are provided that involve targeting lipid scavenging. Methods and compositions for identifying and/or characterizing more or less responsive cancers are also provided.
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公开(公告)号：US09757407B2
公开(公告)日：2017-09-12
申请号：US14977424
申请日：2015-12-21
发明人： Josh Munger , Bryson Bennett , Thomas Shenk , Joshua Rabinowitz
IPC分类号： A61K31/335 , A61K31/7076 , A61K31/381 , A61K31/336 , A61K31/341 , A61K31/365 , A61K31/122 , A61K31/15 , A61K31/194 , A61K31/337 , A61K31/357 , A61K31/403 , A61K31/4545 , A61K31/53 , A61K31/5377 , A61K31/351 , A61K31/675 , A61K31/706 , A61K31/44 , A61K31/22 , A61K31/221 , A61K31/522 , A61K31/52 , A61K31/405
CPC分类号： A61K31/7076 , A61K31/122 , A61K31/15 , A61K31/194 , A61K31/22 , A61K31/221 , A61K31/336 , A61K31/337 , A61K31/341 , A61K31/351 , A61K31/357 , A61K31/365 , A61K31/381 , A61K31/403 , A61K31/405 , A61K31/44 , A61K31/4545 , A61K31/52 , A61K31/522 , A61K31/53 , A61K31/5377 , A61K31/675 , A61K31/706 , Y02A50/463 , A61K2300/00
摘要： Alterations of certain metabolite concentrations and fluxes that occur in response to viral infection are described. Host cell enzymes in the involved metabolic pathways are selected as targets for intervention; i.e., to restore metabolic flux to disadvantage viral replication, or to further derange metabolic flux resulting in “suicide” of viral-infected cells (but not uninfected cells) in order to limit viral propagation. While any of the enzymes in the relevant metabolic pathway can be selected, pivotal enzymes at key control points in these metabolic pathways are preferred as candidate antiviral drug targets. Inhibitors of these enzymes are used to reverse, or redirect, the effects of the viral infection. Drug candidates are tested for antiviral activity using screening assays in vitro and host cells, as well as in animal models. Animal models are then used to test efficacy of candidate compounds in preventing and treating viral infections. The antiviral activity of enzyme inhibitors is demonstrated.
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8.发明申请TREATMENT OF VIRAL INFECTIONS BY MODULATION OF HOST CELL METABOLIC PATHWAYS 审中-公开通过调节宿主细胞代谢途径治疗病毒感染公开(公告)号：US20160346309A1
公开(公告)日：2016-12-01
申请号：US14977424
申请日：2015-12-21
发明人： Josh Munger , Bryson Bennett , Thomas Shenk , Joshua Rabinowitz
IPC分类号： A61K31/7076 , A61K31/336 , A61K31/341 , A61K31/194 , A61K31/381 , A61K31/53 , A61K31/403 , A61K31/4545 , A61K31/5377 , A61K31/357 , A61K31/15 , A61K31/337 , A61K31/365 , A61K31/122
CPC分类号： A61K31/7076 , A61K31/122 , A61K31/15 , A61K31/194 , A61K31/22 , A61K31/221 , A61K31/336 , A61K31/337 , A61K31/341 , A61K31/351 , A61K31/357 , A61K31/365 , A61K31/381 , A61K31/403 , A61K31/405 , A61K31/44 , A61K31/4545 , A61K31/52 , A61K31/522 , A61K31/53 , A61K31/5377 , A61K31/675 , A61K31/706 , Y02A50/463 , A61K2300/00
摘要： Alterations of certain metabolite concentrations and fluxes that occur in response to viral infection are described. Host cell enzymes in the involved metabolic pathways are selected as targets for intervention; i.e., to restore metabolic flux to disadvantage viral replication, or to further derange metabolic flux resulting in “suicide” of viral-infected cells (but not uninfected cells) in order to limit viral propagation. While any of the enzymes in the relevant metabolic pathway can be selected, pivotal enzymes at key control points in these metabolic pathways are preferred as candidate antiviral drug targets. Inhibitors of these enzymes are used to reverse, or redirect, the effects of the viral infection. Drug candidates are tested for antiviral activity using screening assays in vitro and host cells, as well as in animal models. Animal models are then used to test efficacy of candidate compounds in preventing and treating viral infections. The antiviral activity of enzyme inhibitors is demonstrated.
摘要翻译： 描述了响应于病毒感染发生的某些代谢物浓度和通量的变化。 所选代谢途径中的宿主细胞酶被选为干预的目标; 即恢复代谢通量以不利于病毒复制，或进一步破坏导致病毒感染细胞（但不是未感染细胞）“自杀”的代谢通量，以限制病毒传播。 虽然可以选择相关代谢途径中的任何酶，但在这些代谢途径的关键控制点的关键酶优选作为候选抗病毒药物靶标。 这些酶的抑制剂用于逆转或重定向病毒感染的作用。 使用体外和宿主细胞的筛选测定以及动物模型测试候选药物的抗病毒活性。 然后使用动物模型来测试候选化合物在预防和治疗病毒感染中的功效。 证明酶抑制剂的抗病毒活性。
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公开(公告)号：US11607510B2
公开(公告)日：2023-03-21
申请号：US17499151
申请日：2021-10-12
发明人： Joshua Rabinowitz
摘要： The present invention an electronic inhaler for the delivery of pharmaceuticals through vaporization.
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