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公开(公告)号：US20230160850A1
公开(公告)日：2023-05-25
申请号：US17917965
申请日：2021-04-08
IPC分类号： G01N27/414 , B01L3/00
CPC分类号： G01N27/4148 , B01L3/5027 , B01L2300/0663 , B01L2400/0406
摘要： A biomarker detection apparatus in which a CMOS-based chip is used to generate independent detection signals from a reaction zone that receives a biological sample, where the biological sample is provided to both a test region and positive and negative control regions within the reaction zone. The independent detection signals can be processed together (i.e. as a group of input parameters for an algorithm) to identify the presence of a biomarker (or a plurality of biomarkers) in a biological sample. The use of sample-specific, independently detectable positive and negative controls facilitates improved detection accuracy.
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公开(公告)号：US20200168659A1
公开(公告)日：2020-05-28
申请号：US16619444
申请日：2018-06-01
IPC分类号： H01L27/146 , H01L31/0304 , H01L21/02 , H01L31/103
摘要： A method of fabricating a field-effect transistor in which a native oxide layer is removed prior to etching a gate recess. The cleaning step ensures that the etch of the gate recess starts at the same time across an entire sample, such that a uniform gate recess depth and profile can be achieved across an array of field-effect transistors. This results in a highly uniform switch-off voltage for the field-effect transistors in the array.
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公开(公告)号：US20200249175A1
公开(公告)日：2020-08-06
申请号：US16616765
申请日：2018-05-23
IPC分类号： G01N21/80 , G01N27/414
摘要： A CMOS-based chip having multiple sensing modalities that are able independently to detect multiple metabolites present in a sample. In particular, the chip provides multiple sensing modalities capable of performing detection within the same physical test volume, i.e. the chip can simultaneously detect a plurality of chemical reactions occurring in the test volume, where each chemical reaction yields a result that is independently detectable. The chip may comprise an optical sensor (e.g. photodiode) and a chemical sensor (e.g. pH sensor, embodied as an ISFET). With this technique, multiple metabolites may be measured in real time using a small scale point-of-care device.
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公开(公告)号：US20230118814A1
公开(公告)日：2023-04-20
申请号：US18067673
申请日：2022-12-16
发明人： David Robert Sime CUMMING , Samadahn PATIL , Mohammed AL-RAWHANI , Michael BARRETT , Dharmendra DHEEMAN , Chunxiao XU
IPC分类号： G01N21/76 , G01N21/84 , G01N27/414
摘要： A CMOS-based chip having one or more sensing modalities that are able independently to detect multiple metabolites present in a biological sample. The multiple sensing modalities may be provided at different locations with respect to the chip, whereby the chip can simultaneously detect a plurality of metabolites by measuring behaviour of a test material in the different locations. The chip may utilise paper as a transport mechanism for the sample. The paper either conveys the sample to the different locations or itself provides discrete testing zones in which different metabolites can be independently detected. With this technique, multiple metabolites may be measured in real time using a small scale point-of-care device.
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公开(公告)号：US20200292459A1
公开(公告)日：2020-09-17
申请号：US16616838
申请日：2018-05-23
发明人： David Robert Sime CUMMING , Samadahn PATIL , Mohammed AL-RAWHANI , Michael BARRETT , Dharmendra DHEEMAN , Chunxiao HU
IPC分类号： G01N21/76 , G01N21/84 , G01N27/414
摘要： A CMOS-based chip having one or more sensing modalities that are able independently to detect multiple metabolites present in a biological sample. The multiple sensing modalities may be provided at different locations with respect to the chip, whereby the chip can simultaneously detect a plurality of metabolites by measuring behaviour of a test material in the different locations. The chip may utilise paper as a transport mechanism for the sample. The paper either conveys the sample to the different locations or itself provides discrete testing zones in which different metabolites can be independently detected. With this technique, multiple metabolites may be measured in real time using a small scale point-of-care device.
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