公开(公告)号：US11098008B2

公开(公告)日：2021-08-24

申请号：US16776091

申请日：2020-01-29

Applicant: THE UNIVERSITY OF KANSAS

Inventor： Brian S. J. Blagg ,  Rick T. Dobrowsky ,  Mercy Anyika

IPC: C07D311/08 ,  C07C233/18 ,  C07D309/10 ,  C07H15/203 ,  C07D307/20 ,  C07D311/16

Abstract: Provided herein are compounds of the formulas: wherein: n, X2, R3, R3′, R4, R4′, R5, R5′, R6, and R6′ are as defined herein. Pharmaceutical compositions of the compounds are also provided. In some aspects, these compounds may be used for the treatment of diseases, including diabetic peripheral neuropathy or cancer.

公开(公告)号：US11708319B2

公开(公告)日：2023-07-25

申请号：US17375882

申请日：2021-07-14

Applicant: THE UNIVERSITY OF KANSAS

Inventor： Brian S. J. Blagg ,  Rick T. Dobrowsky ,  Mercy Anyika

IPC: C07D311/12 ,  C07C233/18 ,  C07D309/10 ,  C07H15/203 ,  C07D307/20 ,  C07D311/08 ,  C07D311/16

CPC classification number: C07C233/18 ,  C07D307/20 ,  C07D309/10 ,  C07D311/08 ,  C07D311/16 ,  C07H15/203 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/16

Abstract: Provided herein are compounds of the formulas:




wherein: n, X2, R3, R3′, R4, R4′, R5, R5′, R6, and R6′ are as defined herein. Pharmaceutical compositions of the compounds are also provided. In some aspects, these compounds may be used for the treatment of diseases, including diabetic peripheral neuropathy or cancer.

公开(公告)号：US10590065B2

公开(公告)日：2020-03-17

申请号：US15321289

申请日：2015-06-24

Applicant: THE UNIVERSITY OF KANSAS

Inventor： Brian S. J. Blagg ,  Rick T. Dobrowsky ,  Mercy Anyika

IPC: C07C233/18 ,  C07D309/10 ,  C07H15/203 ,  C07D307/20 ,  C07D311/08 ,  C07D311/16

Abstract: Provided herein are compounds of the formulas: (I) wherein: n, X2, R3, R3′, R4, R4′, R5, R5′, R6, and R6′ are as defined herein. Pharmaceutical compositions of the compounds are also provided. In some aspects, these compounds may be used for the treatment of diseases, including diabetic peripheral neuropathy or cancer.