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    CELL-FREE BIOFRAGMENT COMPOSITIONS AND RELATED SYSTEMS, DEVICES, AND METHODS
    4.
    发明申请
    CELL-FREE BIOFRAGMENT COMPOSITIONS AND RELATED SYSTEMS, DEVICES, AND METHODS 审中-公开
    无细胞生物脆性组合物和相关系统，设备和方法

    公开(公告)号：US20150377880A1

    公开(公告)日：2015-12-31

    申请号：US14650851

    申请日：2013-12-10

    申请人： THE UNIVERSITY OF QUEENSLAND ,  SEATTLE BIOMEDICAL RESEARCH INSTITUTE

    发明人： Yadveer Grewal ,  Gerard A. Cangelosi ,  Muhammad J.A. Shiddiky ,  Matt Trau

    IPC分类号： G01N33/566 ,  G01N33/569

    CPC分类号： G01N33/566 ,  G01N33/5432 ,  G01N33/5438 ,  G01N33/56911 ,  G01N33/56961 ,  G01N33/56966 ,  G01N33/56983

    摘要： The present disclosure relates to biofragment compositions that comprise bioparticle fragments and at least one heterologous antigen-binding molecule. In some embodiments, the biofragment is typically derived from a larger, intact bioparticle that express the at least one heterologous antigen-binding molecule at the surface, and the biofragment has increased solubility to facilitate assays for antigen detection. The disclosure also relates the related methods of using and making the biofragment compositions, as well as systems and devices implementing the biofragment compositions. In some embodiments, the related methods, systems and devices do not require additional detection reagents, such as animal derived detection antibodies.

    摘要翻译： 本公开涉及包含生物颗粒片段和至少一种异源抗原结合分子的生物片段组合物。 在一些实施方案中，生物片段通常衍生自在表面表达至少一种异源抗原结合分子的较大的完整生物颗粒，并且生物片段具有增加的溶解度以促进抗原检测的测定。 本公开还涉及使用和制备生物片段组合物的相关方法以及实施生物片段组合物的系统和装置。 在一些实施方案中，相关方法，系统和装置不需要额外的检测试剂，例如动物衍生的检测抗体。

    Nucleic acid detection method and kit
    5.
    发明授权
    Nucleic acid detection method and kit 有权

    公开(公告)号：US10465236B2

    公开(公告)日：2019-11-05

    申请号：US15107121

    申请日：2014-12-23

    申请人： THE UNIVERSITY OF QUEENSLAND

    发明人： Matt Trau ,  Eugene Wee ,  Jose Ramon Botella

    IPC分类号： C12P19/34 ,  C12Q1/6851 ,  C12Q1/6844 ,  C12Q1/689 ,  C12Q1/6893 ,  C12Q1/70

    摘要： A method and kit for detecting a target nucleic acid is provided wherein combining an amplified nucleic acid with a particle such as a paramagnetic bead form a flocculated complex which can be detected by visual inspection. The volume of nucleic acid sample that can be detected is as low as a few microlitres. The method can be applied to in-the-field or point-of-care diagnosis for a rapid determination of the presence or absence of the target nucleic acid. The methylation status of a target nucleic acid can also be determined. The method and lit may have general applicability to detecting diseases in plants and animals, environmental testing and testing for contamination of foods and other edible products.

    PROTEASE-BASED BIOSENSOR
    6.
    发明申请
    PROTEASE-BASED BIOSENSOR 有权
    基于PROTEASE的生物传感器

    公开(公告)号：US20150226731A1

    公开(公告)日：2015-08-13

    申请号：US14427982

    申请日：2013-09-12

    申请人： THE UNIVERSITY OF QUEENSLAND

    发明人： Kirill Alexandrov ,  Viktor Stein ,  Matt Trau

    IPC分类号： G01N33/542 ,  G01N33/573 ,  C12N9/50

    CPC分类号： G01N33/542 ,  C07K16/3069 ,  C07K16/36 ,  C07K2317/22 ,  C07K2317/569 ,  C07K2319/21 ,  C07K2319/50 ,  C07K2319/70 ,  C12N9/503 ,  C12N9/506 ,  C12N15/62 ,  C12N2770/24022 ,  C12N2770/34022 ,  C12Q1/37 ,  G01N33/532 ,  G01N33/54366 ,  G01N33/573 ,  G01N2333/005 ,  G01N2333/18 ,  G01N2333/96463

    摘要： A biosensor molecule comprises: a protease amino acid sequence; at least one sensor comprising at least one sensor amino acid sequence which is responsive to at least one target molecule; and an inhibitor of the protease activity of said protease amino acid sequence; wherein the biosensor is switchable from a protease active to a protease inactive state, or from a protease inactive to a protease active state when said sensor responds to said target molecule. The biosensor protease may be a protease of a virus such as a Potyvirus or a Flavivirus wherein the inhibitor is an autoinhibitory peptide derived from the virus. The biosensor may respond to the target molecule allosterically or may be cleaved by a target protease molecule.

    摘要翻译： 生物传感器分子包括：蛋白酶氨基酸序列; 至少一个传感器包括至少一个对至少一个靶分子有响应的传感器氨基酸序列; 和所述蛋白酶氨基酸序列的蛋白酶活性的抑制剂; 其中当所述传感器响应于所述靶分子时，所述生物传感器可从蛋白酶活性切换到蛋白酶非活性状态，或从无活性蛋白酶转变为蛋白酶活性状态。 生物传感器蛋白酶可以是诸如Potyvirus或黄病毒病毒的病毒的蛋白酶，其中抑制剂是源自病毒的自身抑制肽。 生物传感器可以变构反应靶分子，或者可以被靶蛋白酶分子切割。