公开(公告)号：US10463259B2

公开(公告)日：2019-11-05

申请号：US15293380

申请日：2016-10-14

申请人： Three Rivers Cardiovascular Systems Inc.

发明人： Christopher Glover ,  Eric Caron ,  Sylvain Abel

IPC分类号： A61B5/0215 ,  A61B5/00 ,  A61B5/028 ,  A61F2/24 ,  A61M25/10 ,  A61B5/01 ,  A61B5/0205 ,  A61B5/026 ,  A61B5/0295 ,  G01P5/10 ,  G01K11/32 ,  G01K13/02 ,  G01L11/02 ,  A61B90/00 ,  A61B90/30 ,  G16H40/63 ,  A61B5/024 ,  G06F19/00

摘要： A system and apparatus comprising a multi-sensor catheter for right heart and pulmonary artery catheterization is disclosed. The multi-sensor catheter comprises multi-lumen catheter tubing into which at least three optical pressure sensors, and their respective optical fibers, are inserted. The three optical pressure sensors are arranged within a distal end portion of the catheter, spaced apart lengthwise within the distal end portion for measuring pressure concurrently at each sensor location. The sensor locations are configured for placement of at least one sensor in each of the right atrium, the right ventricle and the pulmonary artery, for concurrent measurement of pressure at each sensor location. The sensor arrangement may further comprise an optical thermo-dilution sensor, and another lumen is provided for fluid injection for thermo-dilution measurements. The catheter may comprise an inflatable balloon tip and a guidewire lumen, and preferably has an outside diameter of 6 French or less.

公开(公告)号：US20160128583A1

公开(公告)日：2016-05-12

申请号：US15001347

申请日：2016-01-20

申请人： THREE RIVERS CARDIOVASCULAR SYSTEMS INC.

发明人： Eric Caron ,  Luc Bilodeau

IPC分类号： A61B5/0215

CPC分类号： A61B5/6851 ,  A61B5/02154 ,  A61B5/02158 ,  A61B5/042 ,  A61B2560/0462 ,  A61B2560/066 ,  A61B2562/228 ,  A61F2/24 ,  A61F2/2418 ,  A61F2/2427

摘要： A system and apparatus comprising a multisensor guidewire for use in interventional cardiology, e.g. for Transcatheter Valve Therapies (TVT), comprises a plurality of optical sensors for direct measurement of cardiovascular parameters, e.g. transvalvular blood pressure gradients and flow. A conventional outer coil contains a shaped core wire having a cross-section defining helical grooves extending along its length, which accommodate optical fibers and optical sensors within a diameter Dcore of the core wire. Advantageously, the diameter and material of the core wire provides the guidewire with sufficient stiffness for use as a support guidewire for valve replacement, e.g. Transcatheter Aortic Valve Implantation (TAVI), while accommodating multiple sensors and optical fibers within a guidewire of outside diameter ≦0.89 mm. An optical connector couples the guidewire to a control system. Optionally, the guidewire includes a contact force sensor; a pre-formed tip; and/or a separable micro-connector for proximal mounting of over-the-guidewire components.

摘要翻译： 一种系统和装置，包括用于介入心脏病学的多传感器导丝，例如。 对于经导管阀门治疗（TVT），包括用于直接测量心血管参数的多个光学传感器，例如。 跨瓣血压梯度和流量。 常规的外部线圈包含成形的芯线，其具有限定沿着其长度延伸的螺旋槽的横截面，其容纳在芯线的直径Dcore内的光纤和光学传感器。 有利地，芯线的直径和材料为引导线提供足够的刚度，用作用于更换瓣膜的支撑导丝，例如， 经导管主动脉瓣植入（TAVI），同时将多个传感器和光纤容纳在外径nlE的导丝内; 0.89mm。 光学连接器将导丝连接到控制系统。 可选地，导丝包括接触力传感器; 一个预先形成的尖端; 和/或可分离的微型连接器，用于近端安装超导线部件。

公开(公告)号：US20140243688A1

公开(公告)日：2014-08-28

申请号：US14354588

申请日：2012-10-25

申请人： Three Rivers Cardiovascular Systems Inc.

发明人： Eric Caron ,  Luc Bilodeau ,  Michel Paquette

IPC分类号： A61B5/01 ,  A61B5/026

CPC分类号： A61B5/02154 ,  A61B5/0002 ,  A61B5/01 ,  A61B5/02055 ,  A61B5/0215 ,  A61B5/024 ,  A61B5/026 ,  A61B5/0261 ,  A61B5/0295 ,  A61B5/6851 ,  A61B5/6852 ,  A61B5/6855 ,  A61B8/488 ,  G01F1/6884 ,  G01K11/32 ,  G01K13/02 ,  G01P5/10 ,  G06F19/3418 ,  G16H40/63

摘要： Apparatus (100) is provided comprising an optical micro-sensor (10) for directly measuring a fluid temperature and flow by thermoconvection, which suitable for medical applications, e.g. using minimally-invasive cardiovascular techniques. A multi-sensor apparatus (100) may take the form of a micro-catheter or steerable guidewire, equipped with a plurality of miniaturized optical sensors (10) arranged along a length of the distal end (101), each coupled via optical fibers (11) to a proximal end (102) comprising an input/output connector (112) to the control system (110), without the need for electrical connections. This enables direct measurement of blood flow, temperature and/or blood pressure simultaneously at several locations within the blood vessels or the heart, including transvalvular measurements. Preferably, the distal end portion has a diameter of 0.89 mm (0.035″) or less, and more preferably 0.46 mm (0.018″) or less, so that there is negligible effect on valve movement, transvalvular pressure gradient and flow during measurement.

摘要翻译： 提供了一种设备（100），其包括用于直接测量流体温度和流量的光学微传感器（10），其通过热对流而适用于医疗应用，例如， 使用微创心血管技术。 多传感器装置（100）可以采取微导管或可导向导丝的形式，其配备有沿着远端（101）的长度布置的多个小型化光学传感器（10），每个小型化光学传感器通过光纤 11）连接到包括到控制系统（110）的输入/输出连接器（112）的近端（102），而不需要电连接。 这使得能够在血管或心脏内的多个位置处同时直接测量血流量，温度和/或血压，包括跨瓣膜测量。 优选地，远端部分的直径为0.89mm（0.035“）或更小，更优选为0.46mm（0.018”）或更小，使得在测量期间对阀移动，跨瓣压力梯度和流动的影响可忽略不计。

公开(公告)号：US11406271B2

公开(公告)日：2022-08-09

申请号：US16764119

申请日：2018-11-13

申请人： Three Rivers Cardiovascular Systems Inc.

发明人： Tom Glawdel ,  Christopher Glover ,  Eric Caron ,  Sylvain Abel

IPC分类号： A61B5/0215 ,  A61B90/00 ,  A61B5/00 ,  A61F2/24

摘要： Dual sensor system for continuous blood pressure monitoring during transcatheter heart valve therapies (TVT), such as transcatheter aortic valve replacement (TAVR) or transcatheter mitral valve replacement (TMVR), comprises a controller, a support guidewire for TVT containing a first Fabry-Pérot (FP) optical pressure sensor near its distal end, and a pigtail catheter for delivery of contrast medium containing a second FP optical pressure sensor near its distal end. For example, for TAVR, the support guidewire is positioned to place the first optical pressure sensor within the left ventricle (LV) for monitoring LV pressure, the pigtail catheter is positioned in the aorta to place the second optical pressure sensor in the ascending aorta for direct measurement of pressure in the aorta, downstream of the aortic valve, enabling continuous monitoring of blood pressure at both sensor locations during TAVR. The controller may be configured to interface with standard patient monitoring systems.

公开(公告)号：US09504392B2

公开(公告)日：2016-11-29

申请号：US14874604

申请日：2015-10-05

申请人： THREE RIVERS CARDIOVASCULAR SYSTEMS INC.

发明人： Eric Caron ,  Luc Bilodeau ,  Michael Paquette

IPC分类号： A61B5/00 ,  A61B5/0215 ,  A61B5/01 ,  A61B5/026 ,  G01F1/688 ,  G01P5/10 ,  G01K11/32 ,  G01K13/02 ,  A61B5/0205 ,  A61B8/08 ,  G06F19/00 ,  A61B5/0295 ,  A61B5/024

CPC分类号： A61B5/02154 ,  A61B5/0002 ,  A61B5/01 ,  A61B5/02055 ,  A61B5/0215 ,  A61B5/024 ,  A61B5/026 ,  A61B5/0261 ,  A61B5/0295 ,  A61B5/6851 ,  A61B5/6852 ,  A61B5/6855 ,  A61B8/488 ,  G01F1/6884 ,  G01K11/32 ,  G01K13/02 ,  G01P5/10 ,  G06F19/3418 ,  G16H40/63

摘要： An apparatus, control system and methods are disclosed for directly measuring a blood pressure gradient, i.e. by real-time pressure measurements, with particular application for in situ measurement of transvalvular blood pressure gradients for the aortic valve and other heart valves, using minimally-invasive techniques. The apparatus takes the form of a multi-sensor assembly, enclosed within a micro-catheter or a steerable guidewire, and comprises a plurality of optical pressure sensors arranged along a length of the distal end portion, for measuring pressure simultaneously at each sensor location. For example, four MOMS optical pressure sensors, and optionally, a temperature and/or flow sensor, are incorporated into a distal end portion having a diameter of 0.89 mm or less, and preferably 0.46 mm or less. Beneficially, all sensors are optically coupled, via respective optical fibers, to an optical coupler at the proximal end of the multi-sensor apparatus, without requiring electrical connections.

摘要翻译： 公开了一种用于直接测量血压梯度的设备，控制系统和方法，即通过实时压力测量，具体应用于主动脉瓣和其他心脏瓣膜的跨瓣血压梯度的原位测量，使用微创 技术 该装置采用封闭在微导管或可导向导丝内的多传感器组件的形式，并且包括沿着远端部分的长度布置的多个光学压力传感器，用于在每个传感器位置同时测量压力。 例如，四个MOMS光学压力传感器和任选的温度和/或流量传感器被并入到直径为0.89mm或更小，优选为0.46mm或更小的远端部分中。 有利的是，所有传感器通过相应的光纤被光耦合到多传感器装置的近端处的光耦合器，而不需要电连接。

公开(公告)号：US11197619B2

公开(公告)日：2021-12-14

申请号：US16587659

申请日：2019-09-30

申请人： Three Rivers Cardiovascular Systems Inc.

发明人： Christopher Glover ,  Eric Caron ,  Sylvain Abel

IPC分类号： A61B5/0215 ,  A61B5/00 ,  A61B5/028 ,  A61F2/24 ,  A61M25/10 ,  A61B5/0295 ,  A61B5/026 ,  G01P5/10 ,  A61B5/0205 ,  G01K11/32 ,  G01K13/02 ,  A61B5/01 ,  G01L11/02 ,  G16H20/40 ,  A61B90/00 ,  A61B90/30 ,  G16H40/63 ,  A61B5/024

摘要： A system and apparatus comprising a multi-sensor catheter for right heart and pulmonary artery catheterization is disclosed. The multi-sensor catheter comprises multi-lumen catheter tubing into which at least three optical pressure sensors, and their respective optical fibers, are inserted. The three optical pressure sensors are arranged within a distal end portion of the catheter, spaced apart lengthwise within the distal end portion for measuring pressure concurrently at each sensor location. The sensor locations are configured for placement of at least one sensor in each of the right atrium, the right ventricle and the pulmonary artery, for concurrent measurement of pressure at each sensor location. The sensor arrangement may further comprise an optical thermo-dilution sensor, and another lumen is provided for fluid injection for thermo-dilution measurements. The catheter may comprise an inflatable balloon tip and a guidewire lumen, and preferably has an outside diameter of 6 French or less.

公开(公告)号：US10722175B2

公开(公告)日：2020-07-28

申请号：US15326134

申请日：2015-07-10

申请人： Three Rivers Cardiovascular Systems Inc.

发明人： Eric Caron ,  Luc Bilodeau

IPC分类号： A61B5/00 ,  A61B5/042 ,  A61B5/0215 ,  A61F2/24

摘要： A system (1) and apparatus comprising a multisensor guidewire (100/200/300) for use in interventional cardiology, e.g., Transcatheter Valve Therapies (TVT), comprises a plurality of optical sensors (10/20) for direct measurement of cardiovascular parameters, e.g. transvalvular blood pressure gradients and flow. A conventional outer coil wire (35) contains a shaped core wire (31) having a cross-section defining a channel surface (132), e.g. grooves (32), extending along its length, to position optical fibers (11) and optical sensors (10/20) in a channel (33). Advantageously, the core wire has a diameter that provides sufficient stiffness to the guidewire for use as a support guidewire for TVT, e.g. Transcatheter Aortic Valve Implantation (TAVI), while accommodating multiple sensors and fibers within a guidewire of outside diameter ≤0.89 mm. An optical connector (112) couples the guidewire to a control system (150). Optionally, the guidewire includes a contact force sensor (60), a pre-formed tip (400-1/400-2) and a separable micro-connector (140).

公开(公告)号：US09149230B2

公开(公告)日：2015-10-06

申请号：US14354624

申请日：2012-10-26

申请人： THREE RIVERS CARDIOVASCULAR SYSTEMS INC.

发明人： Eric Caron ,  Luc Bilodeau ,  Michel Paquette

IPC分类号： A61B5/00 ,  A61B5/01 ,  A61B5/026 ,  A61B5/0215 ,  G01F1/688 ,  G01P5/10 ,  G01K11/32 ,  G01K13/02 ,  A61B5/0205 ,  A61B8/08 ,  G06F19/00 ,  A61B5/0295 ,  A61B5/024

CPC分类号： A61B5/02154 ,  A61B5/0002 ,  A61B5/01 ,  A61B5/02055 ,  A61B5/0215 ,  A61B5/024 ,  A61B5/026 ,  A61B5/0261 ,  A61B5/0295 ,  A61B5/6851 ,  A61B5/6852 ,  A61B5/6855 ,  A61B8/488 ,  G01F1/6884 ,  G01K11/32 ,  G01K13/02 ,  G01P5/10 ,  G06F19/3418 ,  G16H40/63

摘要： An apparatus (100), control system (150) and methods are provided for directly measuring a pressure gradient, i.e. by real-time pressure measurements, with particular application for in situ measurement of transvalvular blood pressure gradients for the aortic valve and other heart valves, using minimally-invasive techniques. The apparatus takes the form of a multi-sensor assembly, e.g. enclosed within a micro-catheter or a steerable guidewire, and comprises a plurality of optical pressure sensors (10) is arranged along a length of the distal end portion (101), for measuring pressure simultaneously at each sensor location. For example, four MOMS optical pressure sensors (10), and optionally, a flow sensor (20), are incorporated into a distal end portion (101) having a diameter of 0.89 mm or less, and preferably 0.46 mm or less. Beneficially, all sensors are optically coupled, via respective optical fibers (11), to an optical coupler (112) at the proximal end of the multi-sensor apparatus, without requiring electrical connections.

摘要翻译： 提供了一种设备（100），控制系统（150）和方法，用于直接测量压力梯度，即通过实时压力测量，具体应用于原位测量主动脉瓣和其他心脏瓣膜的跨瓣血压梯度 ，使用微创技术。 该装置采用多传感器组件的形式，例如， 封闭在微导管或可导向的导丝内，并且包括沿着远端部分（101）的长度布置的多个光学压力传感器（10），用于在每个传感器位置同时测量压力。 例如，四个MOMS光学压力传感器（10）和任选的流量传感器（20）被并入直径为0.89mm或更小，优选为0.46mm或更小的远端部分（101）中。 有利的是，所有传感器经由相应的光纤（11）被光学耦合到多传感器设备的近端的光耦合器（112），而不需要电连接。

公开(公告)号：US20140249386A1

公开(公告)日：2014-09-04

申请号：US14354624

申请日：2012-10-26

申请人： THREE RIVERS CARDIOVASCULAR SYSTEMS INC.

发明人： Eric Caron ,  Luc Bilodeau ,  Michel Paquette

IPC分类号： A61B5/00 ,  A61B5/026 ,  A61B8/08 ,  A61B5/0205

CPC分类号： A61B5/02154 ,  A61B5/0002 ,  A61B5/01 ,  A61B5/02055 ,  A61B5/0215 ,  A61B5/024 ,  A61B5/026 ,  A61B5/0261 ,  A61B5/0295 ,  A61B5/6851 ,  A61B5/6852 ,  A61B5/6855 ,  A61B8/488 ,  G01F1/6884 ,  G01K11/32 ,  G01K13/02 ,  G01P5/10 ,  G06F19/3418 ,  G16H40/63

摘要： An apparatus (100), control system (150) and methods are provided for directly measuring a pressure gradient, i.e. by real-time pressure measurements, with particular application for in situ measurement of transvalvular blood pressure gradients for the aortic valve and other heart valves, using minimally-invasive techniques. The apparatus takes the form of a multi-sensor assembly, e.g. enclosed within a micro-catheter or a steerable guidewire, and comprises a plurality of optical pressure sensors (10) is arranged along a length of the distal end portion (101), for measuring pressure simultaneously at each sensor location. For example, four MOMS optical pressure sensors (10), and optionally, a flow sensor (20), are incorporated into a distal end portion (101) having a diameter of 0.89 mm or less, and preferably 0.46 mm or less. Beneficially, all sensors are optically coupled, via respective optical fibers (11), to an optical coupler (112) at the proximal end of the multi-sensor apparatus, without requiring electrical connections.

摘要翻译： 提供了一种设备（100），控制系统（150）和方法，用于直接测量压力梯度，即通过实时压力测量，具体应用于原位测量主动脉瓣和其他心脏瓣膜的跨瓣血压梯度 ，使用微创技术。 该装置采用多传感器组件的形式，例如， 封闭在微导管或可导向的导丝内，并且包括沿着远端部分（101）的长度布置的多个光学压力传感器（10），用于在每个传感器位置同时测量压力。 例如，四个MOMS光学压力传感器（10）和任选的流量传感器（20）被并入直径为0.89mm或更小，优选为0.46mm或更小的远端部分（101）中。 有利的是，所有传感器经由相应的光纤（11）被光学耦合到多传感器设备的近端的光耦合器（112），而不需要电连接。