公开(公告)号：US20250115906A1

公开(公告)日：2025-04-10

申请号：US18727149

申请日：2023-01-12

Applicant: TOOLGEN INCORPORATED

Inventor： Dong Woo SONG ,  Hyerim LEE ,  Hye-Kyung OH ,  Beom Seok CHOI ,  Kyu Jun LEE ,  Nan Yeong GO ,  Jae Young LEE

IPC: C12N15/113 ,  C12N9/22 ,  C12N15/11 ,  C12N15/86

Abstract: The present invention relates to a Schwann cell-specific promoter and use thereof. More particularly, the present invention relates to an artificially engineered minimal promoter that specifically operates in Schwann cells, wherein the artificially engineered minimal promoter is derived from an MPZ (Myelin Protein Zero or PO) promoter. In addition, the present invention relates to a vector using the Schwann cell-specific promoter and a method for treating Schwann cell-related diseases using same.

公开(公告)号：US20250000912A1

公开(公告)日：2025-01-02

申请号：US18822009

申请日：2024-08-30

Applicant: TOOLGEN INCORPORATED

Inventor： Jae Young LEE ,  Kang In LEE ,  Young Ju SON ,  Nan Yeong GO ,  Eun Ji SHIN ,  Hwan Yeul YU

IPC: A61K35/44 ,  C12N5/071 ,  C12N9/22 ,  C12N15/11 ,  C12N15/90

Abstract: Hypoimmunogenic stem cells and hypoimmunogenic cells differentiated or derived from stem cells are disclosed. The hypoimmunogenic stem cells and the hypoimmunogenic cells differentiated or derived therefrom are capable of inhibiting immune rejection upon transplantation by increasing the expression or activity level of immune activity inhibitory factors. A method of preparing the same and a cell therapeutic agent using the same are also disclosed.