公开(公告)号：US20240166999A1

公开(公告)日：2024-05-23

申请号：US18424920

申请日：2024-01-29

Applicant: TOOLGEN INCORPORATED

Inventor： Eun Ji SHIN ,  Kang In LEE ,  Yu Ri CHOI ,  Hye Jung SHIN ,  Jae Young LEE ,  Hwan Yeul YU

IPC: C12N5/0775 ,  C12N9/16 ,  C12N15/11 ,  C12N15/86

CPC classification number: C12N5/0665 ,  C12N9/16 ,  C12N15/11 ,  C12N15/86 ,  C12N2310/20 ,  C12N2510/00 ,  C12Y301/00

Abstract: Mesenchymal stem cells, a preparation method therefor, and a cell therapeutic agent using same have hemocompatibility since thrombosis thereof is suppressed after the expression or activation level of blood coagulation initiating factor CD142 is reduced or inhibited. When intravascularly administered, the mesenchymal stem cells have improved hemocompatibility since thrombosis thereof, which can be caused by the administered mesenchymal stem cells, is suppressed.

公开(公告)号：US20250000912A1

公开(公告)日：2025-01-02

申请号：US18822009

申请日：2024-08-30

Applicant: TOOLGEN INCORPORATED

Inventor： Jae Young LEE ,  Kang In LEE ,  Young Ju SON ,  Nan Yeong GO ,  Eun Ji SHIN ,  Hwan Yeul YU

IPC: A61K35/44 ,  C12N5/071 ,  C12N9/22 ,  C12N15/11 ,  C12N15/90

Abstract: Hypoimmunogenic stem cells and hypoimmunogenic cells differentiated or derived from stem cells are disclosed. The hypoimmunogenic stem cells and the hypoimmunogenic cells differentiated or derived therefrom are capable of inhibiting immune rejection upon transplantation by increasing the expression or activity level of immune activity inhibitory factors. A method of preparing the same and a cell therapeutic agent using the same are also disclosed.