公开(公告)号：US20210317448A1

公开(公告)日：2021-10-14

申请号：US17262342

申请日：2019-07-25

Applicant: TOOLGEN INCORPORATED

Inventor： Dong Woo SONG ,  Jung Min LEE ,  Kyu Jun LEE ,  Un Gi KIM

IPC: C12N15/11 ,  A61P7/04 ,  A61K38/46 ,  A61K31/7088 ,  C12N9/22 ,  A61K9/00 ,  C12N15/86

Abstract: The present invention relates to a composition for gene manipulation for artificially manipulating a blood coagulation inhibitory gene present in the genome of a cell to regulate a blood coagulation system. More particularly, the present invention relates to a composition for gene manipulation, which includes a guide nucleic acid capable of targeting a blood coagulation inhibitory gene, and an editor protein. Also, the present invention relates to a method of treating or improving coagulopathy using the composition for gene manipulation for artificially manipulating a blood coagulation inhibitory gene.

公开(公告)号：US20200277630A1

公开(公告)日：2020-09-03

申请号：US16650993

申请日：2018-09-28

Applicant: TOOLGEN INCORPORATED ,  SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION ,  SEOUL NATIONAL UNIVERSITY HOSPITAL

Inventor： Dong Woo SONG ,  Jung Min LEE ,  Un Gi KIM ,  Jeong Hun KIM ,  Dong Hyun JO

IPC: C12N15/86 ,  C12N15/113 ,  C12N9/22 ,  A61P27/02

Abstract: The present invention relates to a composition for gene manipulation for treating or improving a retinal dysfunction disease or a method using the same. More particularly, the present invention relates to a composition for gene manipulation including a guide nucleic acid capable of targeting a retinal function-forming gene and a method of treating or improving a disease caused by retinal dysfunction by artificially manipulating and/or correcting a retinal function-forming gene using the same.

公开(公告)号：US20220192163A1

公开(公告)日：2022-06-23

申请号：US17440350

申请日：2020-03-24

Applicant: TOOLGEN INCORPORATED

Inventor： Jae Young LEE ,  Hee Sook BAE ,  Hye Jung SHIN ,  Dong Woo SONG ,  Un Gi KIM ,  Kyu Jun LEE

IPC: A01K67/027 ,  C12N15/10 ,  C12N15/113 ,  C12N15/85 ,  C12N15/90 ,  C12N9/64

Abstract: The present invention relates to a hemophilia B rat and a method of producing the hemophilia B rat. More particularly, the present invention relates to a hemophilia B rat having F9 factor knocked-down or knocked-out and a method of producing the hemophilia B rat.