公开(公告)号：US20240166999A1

公开(公告)日：2024-05-23

申请号：US18424920

申请日：2024-01-29

Applicant: TOOLGEN INCORPORATED

Inventor： Eun Ji SHIN ,  Kang In LEE ,  Yu Ri CHOI ,  Hye Jung SHIN ,  Jae Young LEE ,  Hwan Yeul YU

IPC: C12N5/0775 ,  C12N9/16 ,  C12N15/11 ,  C12N15/86

CPC classification number: C12N5/0665 ,  C12N9/16 ,  C12N15/11 ,  C12N15/86 ,  C12N2310/20 ,  C12N2510/00 ,  C12Y301/00

Abstract: Mesenchymal stem cells, a preparation method therefor, and a cell therapeutic agent using same have hemocompatibility since thrombosis thereof is suppressed after the expression or activation level of blood coagulation initiating factor CD142 is reduced or inhibited. When intravascularly administered, the mesenchymal stem cells have improved hemocompatibility since thrombosis thereof, which can be caused by the administered mesenchymal stem cells, is suppressed.

公开(公告)号：US20240139254A1

公开(公告)日：2024-05-02

申请号：US18407597

申请日：2024-01-09

Applicant: TOOLGEN INCORPORATED

Inventor： Eun Ji SHIN ,  Kang In LEE ,  Yu Ri CHOI ,  Hye Jung SHIN ,  Jae Young LEE

IPC: A61K35/28 ,  C12N5/0775 ,  C12N9/22 ,  C12N15/113

CPC classification number: A61K35/28 ,  C12N5/0662 ,  C12N9/22 ,  C12N15/113 ,  C12N2310/20

Abstract: Provided are mesenchymal stem cells, a preparation method therefor, and a use thereof, the mesenchymal stem cell having oxidative stress resistance by reducing or inhibiting the expression or activity level of KEAP1, which is a negative regulator of Nrf2, so as to increase the activity of Nrf2.

公开(公告)号：US20220192163A1

公开(公告)日：2022-06-23

申请号：US17440350

申请日：2020-03-24

Applicant: TOOLGEN INCORPORATED

Inventor： Jae Young LEE ,  Hee Sook BAE ,  Hye Jung SHIN ,  Dong Woo SONG ,  Un Gi KIM ,  Kyu Jun LEE

IPC: A01K67/027 ,  C12N15/10 ,  C12N15/113 ,  C12N15/85 ,  C12N15/90 ,  C12N9/64

Abstract: The present invention relates to a hemophilia B rat and a method of producing the hemophilia B rat. More particularly, the present invention relates to a hemophilia B rat having F9 factor knocked-down or knocked-out and a method of producing the hemophilia B rat.